eccDNA in maternal plasma

We developed a new bioinformatics method for detecting the eccDNA in plasma. We revealed that the biological properties between eccDNA and linear DNA are different. eccDNA could be potentially provided as a new class of circulating biomarker.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 3 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001005286	We developed a new bioinformatics method for detecting the eccDNA in plasma. We revealed that the biological properties between eccDNA and linear DNA are different. eccDNA could be potentially provided as a new class of circulating biomarker.	Illumina HiSeq 1500 Illumina HiSeq 2500	15

Publications	Citations
Identification and characterization of extrachromosomal circular DNA in maternal plasma. Sin STK, Jiang P, Deng J, Ji L, Cheng SH, Dutta A, Leung TY, Chan KCA, Chiu RWK, Lo YMD. Proc Natl Acad Sci U S A 117: 2020 1658-1665	80
Identification and Characterization of Extrachromosomal Circular DNA in Plasma of Lung Adenocarcinoma Patients. Wu X, Li P, Yimiti M, Ye Z, Fang X, Chen P, Gu Z. Int J Gen Med 15: 2022 4781-4791	9
Integrative profiling of extrachromosomal circular DNA in placenta and maternal plasma provides insights into the biology of fetal growth restriction and reveals potential biomarkers. Lin M, Chen Y, Xia S, He Z, Yu X, Huang L, Lin S, Liang B, Huang Z, Mei S, Liu D, Zheng L, Luo Y. Front Genet 14: 2023 1128082	1