Lothian Birth Cohort 1936 whole genome sequencing study - EGA European Genome-Phenome Archive

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001005478	LBC1921 and LBC1936 GVCFs called with GATK's HaplotypeCaller were combined and subject to variant quality score recalibration. This VCF contains the subset of samples (n = 1068) from the LBC1936 cohort.	Illumina HiSeq X Ten	1068
EGAD00001006414	1075 members of the LBC1936 were sequenced using the Illumina HiSeq X platform. This dataset contains the gvcfs.	Illumina HiSeq X Ten	1075
EGAD00001008774	1075 members of the LBC1936 were sequenced using the Illumina HiSeq X platform. This dataset contains the paired fastq files.	Illumina HiSeq X Ten	1075

Publications	Citations
Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions. Halachev M, Meynert A, Taylor MS, Vitart V, Kerr SM, Klaric L, S. G. P. Consortium, Aitman TJ, Haley CS, Prendergast JG, Pugh C, Hume DA, Harris SE, Liewald DC, Deary IJ, Semple CA, Wilson JF. PLoS Genet 15: 2019 e1008480	15
Using regulatory variants to detect gene-gene interactions identifies networks of genes linked to cell immortalisation. Wragg D, Liu Q, Lin Z, Riggio V, Pugh CA, Beveridge AJ, Brown H, Hume DA, Harris SE, Deary IJ, Tenesa A, Prendergast JGD. Nat Commun 11: 2020 343	5
Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936. Toombs J, Panther L, Ornelas L, Liu C, Gomez E, Martín-Ibáñez R, Cox SR, Ritchie SJ, Harris SE, Taylor A, Redmond P, Russ TC, Murphy L, Cooper JD, Burr K, Selvaraj BT, Browne C, Svendsen CN, Cowley SA, Deary IJ, Chandran S, Spires-Jones TL, Sareen D. Stem Cell Res 46: 2020 101851	14
Rare genetic variants underlie outlying levels of DNA methylation and gene-expression. Chundru VK, Marioni RE, Prendergast JGD, Lin T, Beveridge AJ, Martin NG, Montgomery GW, Hume DA, Deary IJ, Visscher PM, Wray NR, McRae AF. Hum Mol Genet 32: 2023 1912-1921	1