46 CLL Whole Genome Sequencing Study

Chronic lymphocytic leukaemia (CLL) consists of two biologically and clinically distinct subtypes defined by the abundance of somatic hypermutation (SHM) affecting the Ig variable heavy-chain locus (IgHV). The molecular mechanisms underlying these subtypes are incompletely understood. Here, we present a comprehensive whole-genome sequencing analysis of somatically acquired genetic events from 46 CLL patients, including a systematic comparison of coding and non-coding single nucleotide variants, copy number variants and structural variants, regions of kataegis and mutation signatures between IgHVmut and IgHVunmut subtypes.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset

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Dataset ID	Description	Technology	Samples
EGAD00001004384	Whole Genome Sequencing of 44 patients with Chronic Lymphocytic Leukemia. This dataset comprises 44 .bam files aligned to the hg19 build of the human genome from sequencing reads generated on an Illumina HiSeq instrument.	Illumina HiSeq 2500	44