Analysis of IDHwt-glioblastoma samples from paired primary and recurrent tumor samples

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001004563	This dataset contains whole genome sequencing data from 21 primary and relapsed IDH-wt glioblastomas and matched blood controls. Tumors were sequenced at a target coverage of 150x, blood controls at 80x.	HiSeq X Ten	63
EGAD00001004564	This dataset contains strand-specific RNA sequencing data from 16 primary/relapsed sample pairs of IDH-wt glioblastomas	Illumina HiSeq 2000	32
EGAD00001004565	This dataset contains gene panel sequencing data from 43 sample pairs of primary and relapsed IDH-wt glioblastomas. The gene panel covers 50 glioma-associated genes. 14 of the sequenced sample pairs were sequenced with whole genome sequencing also and are accessible under EGAD00001004563.	Ion Torrent Proton	86
EGAD00010001642		Illumina EPIC methylation bead array	25
EGAD00010001643		Illumina 450k methylation bead array	73

Publications	Citations
Time-resolved, integrated analysis of clonally evolving genomes. Legrand C, Andriantsoa R, Lichter P, Raddatz G, Lyko F. PLoS Genet 19: 2023 e1011085	0
IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy. Tanner G, Barrow R, Ajaib S, Al-Jabri M, Ahmed N, Pollock S, Finetti M, Rippaus N, Bruns AF, Syed K, Poulter JA, Matthews L, Hughes T, Wilson E, Johnson C, Varn FS, Brüning-Richardson A, Hogg C, Droop A, Gusnanto A, Care MA, Cutillo L, Westhead DR, Short SC, Jenkinson MD, Brodbelt A, Chakrabarty A, Ismail A, Verhaak RGW, Stead LF. Genome Biol 25: 2024 45	4
A longer time to relapse is associated with a larger increase in differences between paired primary and recurrent IDH wild-type glioblastomas at both the transcriptomic and genomic levels. Ho WM, Chen CY, Chiang TW, Chuang TJ. Acta Neuropathol Commun 12: 2024 77	1