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Exploring_the_landscape_of_somatic_mutations_in_normal_tissue___GI___WGS

The aim of this project is to investiagte somatic mutations, including rates of mutations and signatures, and clonal dynamics in normal (non-cancerous) human tissues from the gastrointestinal tract. The project will involve the studyof normal tissues from healthy individuals and those with specific candidate diseases. We are utilising laser capture microscopy to idnetifiy and isolate specific cell populations which are then subjected to whole genome sequencing to estimate mutational burdens and begin to understand clonal structures across the normal tissues.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001008092 Illumina NovaSeq 6000 161
EGAD00001008764 HiSeq X Ten Illumina NovaSeq 6000 408
Publications Citations
Mutational landscape of normal epithelial cells in Lynch Syndrome patients.
Nat Commun 13: 2022 2710
17