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Leeds Melanoma Cohort (LMC) gene expression study

Array-based profiling (whole genome DASL HT12.4, Illumina Inc) in over 700 FFPE tumour blocks from the population-based Leeds Melanoma cohort recruited in the North of England, with a long follow up. Data used in tumour immune micro-environment investigation (Nsengimana et al 2018, J Clin Invest doi: 10.1172/JCI95351).

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00010001561 Illumina HT12.4 703
EGAD00010001562 Illumina HT12.4 703
Publications Citations
β-Catenin-mediated immune evasion pathway frequently operates in primary cutaneous melanomas.
J Clin Invest 128: 2018 2048-2063
59
Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma.
Cancer Res 79: 2019 2684-2696
29
MX 2 is a novel regulator of cell cycle in melanoma cells.
Pigment Cell Melanoma Res 33: 2020 446-457
9
Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis.
Cancer Discov 10: 2020 980-997
35
PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation.
Dev Cell 54: 2020 317-332.e9
26
Study of the Female Sex Survival Advantage in Melanoma-A Focus on X-Linked Epigenetic Regulators and Immune Responses in Two Cohorts.
Cancers (Basel) 12: 2020 E2082
13
Gene co-expression and histone modification signatures are associated with melanoma progression, epithelial-to-mesenchymal transition, and metastasis.
Clin Epigenetics 12: 2020 127
10
MX2 mediates establishment of interferon response profile, regulates XAF1, and can sensitize melanoma cells to targeted therapy.
Cancer Med 10: 2021 2840-2854
4
Transcriptional signatures underlying dynamic phenotypic switching and novel disease biomarkers in a linear cellular model of melanoma progression.
Neoplasia 23: 2021 439-455
4
Loss of Ambra1 promotes melanoma growth and invasion.
Nat Commun 12: 2021 2550
30
Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype.
Genet Med 23: 2021 1636-1647
1
SFPQ promotes an oncogenic transcriptomic state in melanoma.
Oncogene 40: 2021 5192-5203
18
Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation.
Dev Cell 56: 2021 2808-2825.e10
34
Road to Metastasis: The TWEAK Pathway as a Discriminant between Metastasizing and Non-Metastasizing Thick Melanomas.
Int J Mol Sci 22: 2021 10568
3
ROR2 has a protective role in melanoma by inhibiting Akt activity, cell-cycle progression, and proliferation.
J Biomed Sci 28: 2021 76
8
Genes regulated by DNA methylation are involved in distinct phenotypes during melanoma progression and are prognostic factors for patients.
Mol Oncol 16: 2022 1913-1930
2
Comprehensive Gene Expression Analysis to Identify Differences and Similarities between Sex- and Stage-Stratified Melanoma Samples.
Cells 11: 2022 1099
2
Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival.
Clin Epigenetics 14: 2022 68
3
Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma.
Cancer Discov 13: 2023 194-215
5
N6-methyladenosine RNA Methylation Correlates with Immune Microenvironment and Immunotherapy Response of Melanoma.
J Invest Dermatol 143: 2023 1579-1590.e5
3
Tumour-intrinsic endomembrane trafficking by ARF6 shapes an immunosuppressive microenvironment that drives melanomagenesis and response to checkpoint blockade therapy.
Nat Commun 15: 2024 6613
0