Single-cell profiling maps the spectrum of crosstalk between glioma cells and tumor associated macrophages

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Dataset ID	Description	Technology	Samples
EGAD00001003107	We collected fresh tissue from an untreated GBM directly from the operating room and subjected the biopsy to single-cell RNA-seq with the fluidigm C1 machine after selection of CD11b+ cells using magnetic beads.	Illumina HiSeq 2500	1
EGAD00001003108	We collected fresh tissue from an untreated GBM directly from the operating room and subjected the biopsy to single-cell RNA-seq with the fluidigm C1 machine after selection of CD11b+ cells using magnetic beads.	Illumina HiSeq 2500	1
EGAD00001003109	We collected fresh tissue from an untreated GBM directly from the operating room and subjected the biopsy to single-cell RNA-seq with the fluidigm C1 machine after selection of CD11b+ cells using magnetic beads.	Illumina HiSeq 2500	1
EGAD00001003110	We collected fresh tissue from an untreated GBM directly from the operating room and subjected the biopsy to single-cell RNA-seq with the fluidigm C1 machine after selection of CD11b+ cells using magnetic beads.	Illumina HiSeq 2500	1
EGAD00001003111	We collected fresh tissue from an untreated GBM directly from the operating room and subjected the biopsy to single-cell RNA-seq with the fluidigm C1 machine after selection of CD11b+ cells using magnetic beads.	Illumina HiSeq 2500	1
EGAD00001003112	We collected fresh tissue from an untreated GBM (SF10592) directly from the operating room and subjected the biopsy to single-cell RNA-seq with the fluidigm C1 machine, resulting in sequencing libraries from 96 individual cells.	Illumina HiSeq 2500	1
EGAD00001003113	We collected fresh tissue from an untreated GBM (SF10679) directly from the operating room and subjected the biopsy to single-cell RNA-seq with the fluidigm C1 machine, resulting in sequencing libraries from 96 individual cells.	Illumina HiSeq 2500	1
EGAD00001003114	We collected fresh tissue from an untreated GBM (SF10281) directly from the operating room and subjected the biopsy to single-cell RNA-seq with the fluidigm C1 machine, resulting in sequencing libraries from 96 individual cells.	Illumina HiSeq 2500	1

Publications	Citations
Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment. Müller S, Kohanbash G, Liu SJ, Alvarado B, Carrera D, Bhaduri A, Watchmaker PB, Yagnik G, Di Lullo E, Malatesta M, Amankulor NM, Kriegstein AR, Lim DA, Aghi M, Okada H, Diaz A. Genome Biol 18: 2017 234	353
CONICS integrates scRNA-seq with DNA sequencing to map gene expression to tumor sub-clones. Müller S, Cho A, Liu SJ, Lim DA, Diaz A. Bioinformatics 34: 2018 3217-3219	56
The Phenotypes of Proliferating Glioblastoma Cells Reside on a Single Axis of Variation. Wang L, Babikir H, Müller S, Yagnik G, Shamardani K, Catalan F, Kohanbash G, Alvarado B, Di Lullo E, Kriegstein A, Shah S, Wadhwa H, Chang SM, Phillips JJ, Aghi MK, Diaz AA. Cancer Discov 9: 2019 1708-1719	162
Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states. Chaligne R, Gaiti F, Silverbush D, Schiffman JS, Weisman HR, Kluegel L, Gritsch S, Deochand SD, Gonzalez Castro LN, Richman AR, Klughammer J, Biancalani T, Muus C, Sheridan C, Alonso A, Izzo F, Park J, Rozenblatt-Rosen O, Regev A, Suvà ML, Landau DA. Nat Genet 53: 2021 1469-1479	91
Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow-Derived Macrophages. Wu M, Wu L, Wu W, Zhu M, Li J, Wang Z, Li J, Ding R, Liang Y, Li L, Zhang T, Huang B, Cai Y, Li K, Li L, Zhang R, Hu B, Lin F, Wang X, Zheng S, Chen J, You Y, Jiang T, Zhang J, Chen H, Wang Q. Cancer Res 83: 2023 771-785	11
Glioblastoma heterogeneity at single cell resolution. Eisenbarth D, Wang YA. Oncogene 42: 2023 2155-2165	27
Dissecting the tumor microenvironment of epigenetically driven gliomas: Opportunities for single-cell and spatial multiomics. Sussman JH, Sussman JH, Xu J, Amankulor N, Tan K. Neurooncol Adv 5: 2023 vdad101	0
Single-cell characterization of human GBM reveals regional differences in tumor-infiltrating leukocyte activation. Schmassmann P, Roux J, Dettling S, Hogan S, Shekarian T, Martins TA, Ritz MF, Herter S, Bacac M, Hutter G. Elife 12: 2023 RP92678	2