Dense_fine_mapping_study_identifies_new_susceptibility_loci_for_primary_biliary_cirrhosis

2,981 primary biliary cirrhosis (PBC) cases were collected by the UK PBC Consortium and genotyped on the Illumina Immunochip where 2,861 passed quality control. These cases were then compared to a UK population control to identify novel PBC risk loci and fine-map association signals. (Liu & Almarri et al., Nat Genet, 2012)

Type: Population Genomics
Archiver: European Genome-Phenome Archive (EGA)

2 Datasets 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00010000928	WTCCC3_Primary Biliary Cirrhosis Replication Post-QC	Illumina ImmunoChip	2861
EGAD00010000929	WTCCC3_Primary Biliary Cirrhosis Replication	Illumina ImmunoChip	2981

Publications	Citations
Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis. Darlay R, Ayers KL, Mells GF, Hall LS, Liu JZ, Almarri MA, Alexander GJ, Jones DE, Sandford RN, Anderson CA, Cordell HJ. PLoS Genet 14: 2018 e1007833	5