Comparison of HCC cell lines and primary HCCs

There are concerns about whether cancer cell lines could faithfully represent the matched primary cancer cells. Comparison of the HCC cell lines and primary HCCs demonstrated that, during long-term in vitro culture, cell lines retain the genetic landscape of the matched primary HCCs.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 3 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001001995	Whole genome sequencing (30X) using Hiseq X TEN on 4 HCC cell lines, primary HCCs and early-passage PDCs	HiSeq X Ten	12

Publications	Citations
Hepatocellular carcinoma cell lines retain the genomic and transcriptomic landscapes of primary human cancers. Qiu Z, Zou K, Zhuang L, Qin J, Li H, Li C, Zhang Z, Chen X, Cen J, Meng Z, Zhang H, Li Y, Hui L. Sci Rep 6: 2016 27411	32
Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data. Farmery JHR, Smith ML, NIHR BioResource - Rare Diseases, Lynch AG. Sci Rep 8: 2018 1300	37
A Pharmacogenomic Landscape in Human Liver Cancers. Qiu Z, Li H, Zhang Z, Zhu Z, He S, Wang X, Wang P, Qin J, Zhuang L, Wang W, Xie F, Gu Y, Zou K, Li C, Li C, Wang C, Cen J, Chen X, Shu Y, Zhang Z, Sun L, Min L, Fu Y, Huang X, Lv H, Zhou H, Ji Y, Zhang Z, Meng Z, Shi X, Zhang H, Li Y, Hui L. Cancer Cell 36: 2019 179-193.e11	100