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Population whole-genome bisulfite sequencing across two tissues highlights environment as principal source of human methylome variation

The study includes whole-genome bisulfite sequencing (WGBS) on 34 adipose(7 MZ pairs, 6 DZ pairs and 8 singletons) and 27 blood (7 MZ pairs, 6 DZpairs and 1 singleton) DNA samples derived from a total of 43 female twinsbelonging to the MuTHER/TwinsUK cohort. We generated 11.5 billion 100bppaired-end reads covering 2.3 Tera-basepairs (Tbp) ofsequence using the Illumina HiSeq2000 or 2500 systems. Applying standardalignment methods and filters we obtain a mean genome coverage of 6.3-fold(range: 1.0- to 12.9-fold) for adipose and 8.7-fold (range: 0.7- to29.0-fold) for blood.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001001688 Illumina HiSeq 2500 34
EGAD00001001689 Illumina HiSeq 2500 27
Publications Citations
Population whole-genome bisulfite sequencing across two tissues highlights the environment as the principal source of human methylome variation.
Genome Biol 16: 2015 290
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