Colorectal_organoids_and_tumour_tissue___Whole_Genome_X10

Whole genome sequencing of single cell derived organoids from normal colon tissue and colorectal cancer.

1 Dataset

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Dataset ID	Description	Technology	Samples
EGAD00001015406	A paradigm of childhood cancers is that they have a low mutation burden, with some ostensibly bearing fewer mutations than the normal tissues from which they derive. We set out to resolve this paradox by examining paediatric renal cancers with exceptionally few mutations using high resolution, high depth sequencing approaches. We found that apparent hypomutation was the result of unusual clonal architecture due to a normal tissue-like mode of tumour evolution, raising the possibility that the mutation burden of some cancers has been systematically misjudged.	HiSeq X Ten Illumina NovaSeq 6000	-