Frequent alterations in cytoskeleton remodeling genes in primary and metastatic Chinese lung adenocarcinomas

The landscape of genetic alterations in lung adenocarcinoma derived from Asian patients is largely uncharacterized. Here we present an integrated genomic and transcriptomic analysis of 335 primary lung adenocarcinomas and 35 corresponding lymph node metastases from Chinese patients. Altogether 13 significantly mutated genes are identified, including themost commonly mutated gene TP53 and novel mutation targets such as RHPN2, GLI3 and MRC2. TP53 mutations are furthermore significantly enriched in tumours from patients harbouring metastases. Genes regulating cytoskeleton remodelling processes are also frequently altered, especially in metastatic samples, of which the high expression level of IQGAP3 is identified as a marker for poor prognosis. Our study represents the first large-scalesequencing effort on lung adenocarcinoma in Asian patients and provides a comprehensive mutational landscape for both primary and metastatic tumours. This may thus form a basis for personalized medical care and shed light on the molecular pathogenesis of metastatic lung adenocarcinoma.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

2 Datasets 3 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001001397	We sequenced 292 patients who were suffering NSCLC with Whole genome sequencing or Exome sequencing method.	Illumina HiSeq 2000	72
EGAD00001001398	We sequenced 205 patients who were suffering NSCLC with Exome sequencing method.	Illumina HiSeq 2000	147

Publications	Citations
Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas. Wu K, Zhang X, Li F, Xiao D, Hou Y, Zhu S, Liu D, Ye X, Ye M, Yang J, Shao L, Pan H, Lu N, Yu Y, Liu L, Li J, Huang L, Tang H, Deng Q, Zheng Y, Peng L, Liu G, Gu X, He P, Gu Y, Lin W, He H, Xie G, Liang H, An N, Wang H, Teixeira M, Vieira J, Liang W, Zhao X, Peng Z, Mu F, Zhang X, Xu X, Yang H, Kristiansen K, Wang J, Zhong N, Wang J, Pan-Hammarström Q, He J. Nat Commun 6: 2015 10131	72
The genomic dynamics during progression of lung adenocarcinomas. Yang B, Luo L, Luo W, Zhou Y, Yang C, Xiong T, Li X, Meng X, Li L, Zhang X, Wang Z, Wang Z. J Hum Genet 62: 2017 783-788	6
Screening for viruses in lung adenocarcinoma in China. Chen Z, Liang P, Xu H, Yang S, Liu J, Chen S, Zhong R, Sugimoto A, Liang W, He J, Kawaguchi T. Chin Med J Pulm Crit Care Med 2: 2024 197-199	0