Unraveling metastatic progression of breast cancer
To reconstruct the trajectories of BC progression, we performed exome sequencing (Illumina HiSeq2000, Truseq DNA sample preparation kit v2 and Exome Enrichment Kit v2; alignement done with BWA, substitutions and indels called with GATK and DINDEL respectively) coupled to validation by Sequenom and deep re-sequencing (ongoing), as well as copy number (CN) analyses (Oncoscan, Affymetrix) on DNA from matched primary (n=1-6/pt), axillary lymph node (ALN, n=1-6 for 4 pts), local recurrence (for 1 pt) and distant metastatic (n=1-5/pt) FFPE samples obtained from an autopsy series of 10 BC pts.
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001000836 | Illumina HiSeq 2000 | 49 |
Publications | Citations |
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Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations.
Nat Commun 8: 2017 14944 |
96 |
Minimal functional driver gene heterogeneity among untreated metastases.
Science 361: 2018 1033-1037 |
151 |
Phylogenetic Tree Inference: A Top-Down Approach to Track Tumor Evolution.
Front Genet 10: 2019 1371 |
3 |