Genome-wide mutation analysis of germinal-center B-cell derived lymphomas within the ICGC MMML-Seq Consortium

Germinal-center B-cell derived lymphomas (GCB-lymphomas) are the most common B-cell lymphomas in children and adults, with Burkitt Lymphomas (BL) predominating in childhood and follicular lymphoma (FL) and diffuse large B-cell lymphomas (DLBCL) predominating in older age groups. The cell-of-origin in all these lymphomas is supposed to be a germinal center B-cell and transformation of FL in DLBCL or intermediate DLBCL/BL (intL) can occur. In the framework of the German ICGC MMML-Seq we are currently exploring sequencing data of GCB-lymphomas and paired normal controls as well as normal B-cell subsets separated by FACS. This includes whole genome, transcriptome, miRNAome and whole methylome datasets.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

11 Datasets 3 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001000278	ICGC MMML-seq Data Freeze November 2012 whole genome sequencing	Illumina HiSeq 2000	12
EGAD00001000279	ICGC MMML-seq Data Freeze November 2012 whole exome sequencing	Illumina Genome Analyzer IIx	4
EGAD00001000281	ICGC MMML-seq Data Freeze November 2012 transcriptome sequencing	Illumina HiSeq 2000	6
EGAD00001000355	ICGC MMML-seq Data Freeze March 2013 whole genome sequencing	Illumina HiSeq 2000	46
EGAD00001000356	ICGC MMML-seq Data Freeze March 2013 transcriptome sequencing	Illumina HiSeq 2000	23
EGAD00001000645	ICGC MMML-seq Data Freeze July 2013 whole genome sequencing		42
EGAD00001000648	ICGC MMML-seq Data Freeze July 2013 transcriptome sequencing		31
EGAD00001000650	ICGC MMML-seq Data Freeze July 2013 miRNA sequencing		52
EGAD00001001619	miRNA seq data of 43 cases out of dataset EGAD00001000650 (MMML)		43
EGAD00010000377	DNA methylation analysis of 6 primary lymphoma samples	HumanMethylation450k Bead Chip - Genome Studio	6
EGAD00010000379	DNA methylation analysis of 2 peripheral blood samples	HumanMethylation450k Bead Chip - Genome Studio	2

Publications	Citations
Hypermutation of the inactive X chromosome is a frequent event in cancer. Jäger N, Schlesner M, Jones DT, Raffel S, Mallm JP, Junge KM, Weichenhan D, Bauer T, Ishaque N, Kool M, Northcott PA, Korshunov A, Drews RM, Koster J, Versteeg R, Richter J, Hummel M, Mack SC, Taylor MD, Witt H, Swartman B, Schulte-Bockholt D, Sultan M, Yaspo ML, Lehrach H, Hutter B, Brors B, Wolf S, Plass C, Siebert R, Trumpp A, Rippe K, Lehmann I, Lichter P, Pfister SM, Eils R. Cell 155: 2013 567-581	48
Integrative whole-genome sequence analysis reveals roles of regulatory mutations in BCL6 and BCL2 in follicular lymphoma. Batmanov K, Wang W, Bjørås M, Delabie J, Wang J. Sci Rep 7: 2017 7040	14
Integrating whole genome sequencing, methylation, gene expression, topological associated domain information in regulatory mutation prediction: A study of follicular lymphoma. Farooq A, Trøen G, Delabie J, Wang J. Comput Struct Biotechnol J 20: 2022 1726-1742	2