Whole-genome sequencing analysis of low-grade astrocytomas within the ICGC PedBrain Tumor Project
In order to investigate the full range of genetic alterations contributing to the tumourigenesis of low-grade astrocytoma, we have conducted a next-generation sequencing-based analysis on a large series of matched tumor-normal pairs. This study, conducted by the International Cancer Genome Consortium PedBrain Tumor Project (ICGC PedBrain, http://www.pedbraintumor.org/), has revealed multiple new insights into the biological basis of this tumor entity.
- Type: Whole Genome Sequencing
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001000271 | Illumina HiSeq 2000 | 10 | |
EGAD00001000616 | Illumina HiSeq 2000 | 192 | |
EGAD00001000617 | Illumina HiSeq 2000 | 73 |
Publications | Citations |
---|---|
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.
Nat Genet 45: 2013 927-932 |
479 |
confFuse: High-Confidence Fusion Gene Detection across Tumor Entities.
Front Genet 8: 2017 137 |
7 |
Pilocytic astrocytoma demethylation and transcriptional landscapes link bZIP transcription factors to immune response.
Neuro Oncol 22: 2020 1327-1338 |
8 |
Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma.
Acta Neuropathol 146: 2023 551-564 |
2 |