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Genetic landscape of pediatric Low Grade Gliomas & Glioneuronal tumors

We performed whole-genome sequencing of 42 paired tumor/normal LGG genomes and analyzed somatically acquired single nucleotide variations (SNVs), insertion/deletions, structural variations and copy number variations in the cancer genomes

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000161 Illumina HiSeq 2000 33
EGAD00001000352 Illumina HiSeq 2000 7
EGAD00001000353 Illumina HiSeq 2000 45
EGAD00001000655 Illumina HiSeq 2000 8
EGAD00001000695 Illumina HiSeq 2000 46
EGAD00001001352 Illumina HiSeq 2000 38
EGAD00001001432 Illumina HiSeq 2000 1337
EGAD00001001664 Illumina HiSeq 2000 18
EGAD00001001665 Illumina HiSeq 2000 61
EGAD00001001666 Illumina HiSeq 2000 34
EGAD00010000462 Affymetrix_U133v2 75
Publications Citations
Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data.
Genome Biol 13: 2012 R113
23
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas.
Nat Genet 45: 2013 602-612
500
Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia.
Nat Genet 45: 2013 1386-1391
176
CONSERTING: integrating copy-number analysis with structural-variation detection.
Nat Methods 12: 2015 527-530
54
Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology.
Acta Neuropathol 131: 2016 833-845
194
novoBreak: local assembly for breakpoint detection in cancer genomes.
Nat Methods 14: 2017 65-67
54
CICERO: a versatile method for detecting complex and diverse driver fusions using cancer RNA sequencing data.
Genome Biol 21: 2020 126
57
The landscape of coding RNA editing events in pediatric cancer.
BMC Cancer 21: 2021 1233
6
Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers.
Nat Cancer 4: 2023 276-289
15