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20_Matched_Pair_Breast_Cancer_Genomes

We propose to definitively characterise the somatic genetics of 20 breast cancers through generation of comprehensive catalogues of somatic mutations by high coverage genome sequencing coupled with integrated transcriptomic data.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000082 Illumina Genome Analyzer II Illumina HiSeq 2000 42
EGAD00001000138 Illumina Genome Analyzer II Illumina HiSeq 2000 58
EGAD00001001335 Illumina Genome Analyzer II Illumina HiSeq 2000 28
EGAD00001001338 Illumina Genome Analyzer II Illumina HiSeq 2000 49
EGAD00001002237 Illumina Genome Analyzer II Illumina HiSeq 2000 59
EGAD00001002696 HiSeq X Ten Illumina HiSeq 2000 58
Publications Citations
Genomic Evolution of Breast Cancer Metastasis and Relapse.
Cancer Cell 32: 2017 169-184.e7
360
Integrative reconstruction of cancer genome karyotypes using InfoGenomeR.
Nat Commun 12: 2021 2467
4
A Cluster-Based Approach for the Discovery of Copy Number Variations From Next-Generation Sequencing Data.
Front Genet 12: 2021 699510
0
Spatial genomics maps the structure, nature and evolution of cancer clones.
Nature 611: 2022 594-602
49
Evolving copy number gains promote tumor expansion and bolster mutational diversification.
Nat Commun 15: 2024 2025
7