CLL_Cancer_Whole_Genome_Sequencing

Genomic libraries (500 bps) will be generated from total genomic DNA derived from a range of cancer samples and subjected paired end sequencing on the llumina GA. Paired reads will be mapped to build 37 of the human reference genome to facilitate the generation of genome wide copy number information, and the identification of novel rearranged cancer genes and gene fusions.

Type: Cancer Genomics
Archiver: European Genome-Phenome Archive (EGA)

4 Datasets

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001000002	Massive genomic rearrangement acquired in a single catastrophic event during cancer development	Illumina Genome Analyzer Illumina Genome Analyzer II	1
EGAD00001000013	CLL Cancer Whole Genome Sequencing	Illumina Genome Analyzer II	19
EGAD00001001447	Whole genome sequencing of single cell derived organoids from normal colon tissue and colorectal cancer.	HiSeq X Ten	19
EGAD00001015406	A paradigm of childhood cancers is that they have a low mutation burden, with some ostensibly bearing fewer mutations than the normal tissues from which they derive. We set out to resolve this paradox by examining paediatric renal cancers with exceptionally few mutations using high resolution, high depth sequencing approaches. We found that apparent hypomutation was the result of unusual clonal architecture due to a normal tissue-like mode of tumour evolution, raising the possibility that the mutation burden of some cancers has been systematically misjudged.	HiSeq X Ten Illumina NovaSeq 6000	-