WTCCC3 case-control study for Primary Biliary Cirrhosis

Genome-wide association scan was performed in 1,840 cases of primary biliary cirrhosis and 5,163 controls. Replication of new associations was tested in an independent set of 620 cases and 2,514 controls.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

3 Datasets 3 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00000000022	WTCCC2 project samples from 1958 British Birth Cohort		3000
EGAD00000000024	WTCCC2 project samples from National Blood Donors (NBS) Cohort		1
EGAD00000000056	WTCCC project samples from the primary biliary cirrhosis cohort	Illumina 610K Quad	1705

Publications	Citations
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. Mells GF, Floyd JA, Morley KI, Cordell HJ, Franklin CS, Shin SY, Heneghan MA, Neuberger JM, Donaldson PT, Day DB, Ducker SJ, Muriithi AW, Wheater EF, Hammond CJ, Dawwas MF, UK PBC Consortium, Wellcome Trust Case Control Consortium 3, Jones DE, Peltonen L, Alexander GJ, Sandford RN, Anderson CA. Nat Genet 43: 2011 329-332	302
Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network. Richard AC, Peters JE, Lee JC, Vahedi G, Schäffer AA, Siegel RM, Lyons PA, Smith KG. Genome Med 8: 2016 76	9
Powerful testing via hierarchical linkage disequilibrium in haplotype association studies. Balliu B, Houwing-Duistermaat JJ, Böhringer S. Biom J 61: 2019 747-768	2