Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
Wellcome Trust Case Control Consortium.
Nature
447 :
2007
661-678
5950
Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network.
Richard AC, Peters JE, Lee JC, Vahedi G, Schäffer AA, Siegel RM, Lyons PA, Smith KG.
Genome Med
8 :
2016
76
9
Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease.
Lee JC, Biasci D, Roberts R, Gearry RB, Mansfield JC, Ahmad T, Prescott NJ, Satsangi J, Wilson DC, Jostins L, Anderson CA, UK IBD Genetics Consortium, Traherne JA, Lyons PA, Parkes M, Smith KG.
Nat Genet
49 :
2017
262-268
135
Leveraging functional annotations in genetic risk prediction for human complex diseases.
Hu Y, Lu Q, Powles R, Yao X, Yang C, Fang F, Xu X, Zhao H.
PLoS Comput Biol
13 :
2017
e1005589
94
Joint modeling of genetically correlated diseases and functional annotations increases accuracy of polygenic risk prediction.
Hu Y, Lu Q, Liu W, Zhang Y, Li M, Zhao H.
PLoS Genet
13 :
2017
e1006836
40
Leveraging putative enhancer-promoter interactions to investigate two-way epistasis in Type 2 Diabetes GWAS.
Manduchi E, Chesi A, Hall MA, Grant SFA, Moore JH.
Pac Symp Biocomput
23 :
2018
548-558
1
Leveraging epigenomics and contactomics data to investigate SNP pairs in GWAS.
Manduchi E, Williams SM, Chesi A, Johnson ME, Wells AD, Grant SFA, Moore JH.
Hum Genet
137 :
2018
413-425
6
SumHer better estimates the SNP heritability of complex traits from summary statistics.
Speed D, Balding DJ.
Nat Genet
51 :
2019
277-284
109
Genomic GPS: using genetic distance from individuals to public data for genomic analysis without disclosing personal genomes.
Kim K, Baik H, Jang CS, Roh JK, Eskin E, Han B.
Genome Biol
20 :
2019
175
3
Discovering genetic interactions bridging pathways in genome-wide association studies.
Fang G, Wang W, Paunic V, Heydari H, Costanzo M, Liu X, Liu X, VanderSluis B, Oately B, Steinbach M, Van Ness B, Schadt EE, Pankratz ND, Boone C, Kumar V, Myers CL.
Nat Commun
10 :
2019
4274
40
shaPRS: Leveraging shared genetic effects across traits or ancestries improves accuracy of polygenic scores.
Kelemen M, Vigorito E, Fachal L, Anderson CA, Wallace C.
Am J Hum Genet
111 :
2024
1006-1017
3
Unveiling new genetic insights in rheumatoid arthritis for drug discovery through Taxonomy3 analysis.
Kozlowska J, Humphryes-Kirilov N, Pavlovets A, Connolly M, Kuncheva Z, Horner J, Manso AS, Murray C, Fox JC, McCarthy A.
Sci Rep
14 :
2024
14153
0
Network medicine-based epistasis detection in complex diseases: ready for quantum computing.
Hoffmann M, Poschenrieder JM, Incudini M, Baier S, Fritz A, Maier A, Hartung M, Hoffmann C, Trummer N, Adamowicz K, Picciani M, Scheibling E, Harl MV, Lesch I, Frey H, Kayser S, Wissenberg P, Schwartz L, Hafner L, Acharya A, Hackl L, Grabert G, Lee SG, Cho G, Cloward ME, Jankowski J, Lee HK, Tsoy O, Wenke N, Pedersen AG, Bønnelykke K, Mandarino A, Melograna F, Schulz L, Climente-González H, Wilhelm M, Iapichino L, Wienbrandt L, Ellinghaus D, Van Steen K, Grossi M, Furth PA, Hennighausen L, Di Pierro A, Baumbach J, Kacprowski T, List M, Blumenthal DB.
Nucleic Acids Res
52 :
2024
10144-10160
0