Quantitative Exploratory Proteomics Analysis of Glioblastoma in Initial and Recurrent Tumors
Shotgun Proteomics; Glioblastoma samples from 11 patients were obtained at initial and recurrent tumor stages. Proteins were extracted, identified and quantified via tandem mass spectrometry based on a TMT isobaric labelling approach. Quatitative proteomics reveals 146 differentially abundant proteins using a patient-matched statistical modelling. Analysis of proteolytic processing reveals differential proteolytic patterns in recurrent tumors. Proteogenomics reveals the presense of 30 single-amino acid variants present in glioblastoma tumor and 1 of those as increased in recurrent tumor.
- 25/08/2022
- 22 samples
- DAC: EGAC00001002750
- Technology: Qexactive Plus
Accesss to the spectral data, intermediate search results, proteogenomics database, and normalized abundance values of protein and peptides from glioblastoma tissue.
The recipient of the files agrees to fully consent to the Data Access Agreement (DAA) provided bu the Institute of Surgical Pathology for access to spectral data, intermediary search results and normalized proteomics abundance data from glioblastoma tissue samples. This is based on the harmonized DAA as provided by the EGA
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
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