Whole transcriptome and 850k methylome profiling of human MBM

• COL DUO:0000020 (version: 2021-02-23)collaboration requiredThis data use modifier indicates that the requestor must agree to collaboration with the primary study investigator(s).

Whole transcriptome analyses of intraoperative or snap frozen and 850k methylome analyses of snap frozen or FFPE samples of brain metastases of melanoma patients was performed.

1. The Data will be used solely for the Research by Recipient Investigator and personnel under his immediate supervision at Recipient, and may not be transferred to any other investigator or to any third party without prior written permission from Provider. The Material may not be used for any pulpose other than the Research, including without limitation for any commercial purpose or for research in human subjects (including, without limitation, in diagnostic testing). 2. Neither Recipient nor Recipient Investigator shall disclose Data to any person or party other than the Recipient Investigator hereunder without Provider's prior written consent. 3. The Data will be used in compliance with all applicable laws, regulations, and guidelines applicable to the Data, including without limitation any applicable expott controls. 4. In any publication resulting from use of the Data, Recipient and Recipient Investigator shall acknowledge Dr. Torben Redmer or Dr. Josefine Radke ("Provider lnvestigator") and Provider as the provider of the Data. 5, This Agreement shall be effective as of the Effective Date and shall remain effective until completion of the Research. Either Parly may terminate this Agreement with or without cause upon thirty (30) days' written notice to the other Party. Upon expiratio! or termination of this Agreement for any reason, Recipient shall destroy all Data received pursuant to this Agreement. 6. Any notice permitted or required as provided for herein shall be in writing and to the contact and address as noted below or as may be provided by either party to the other in writing from time to time. 7. Access can be obtained by contacting the appropriate Data Access Committee listed in the study. Access will be granted to commercial and non-commercial parties according to patient consent forms and data transfer agreements. A response to requests for data access can be expected within 14 days. After access has been granted, the data is available for two years. Notice to Provider shall be to: Dr Josefine Radke University of Greifswald, Germany Institute of Pathology josefine.radke@med.uni-greifswald.de