Exome sequencing of UK Birth Cohorts - Avon Longitudinal Study of Parents and Children

ALSPAC whole exome sequencing data sharing policy 15/07/2024 ALSPAC currently releases this dataset through the EGA via EGADXXX (alspac dataset ID) and through the study’s own omics dataset release system. If you wish to access additional data held by ALSPAC that is not available in this dataset, you can request it from ALSPAC directly along with the other datasets (note that costs may apply). To gain access to EGAD00001015371: - Please submit an access request on the EGA. - Visit https://www.bristol.ac.uk/alspac/researchers/access/ where you can find the access policy and where to submit a research proposal to ALSPAC. - You will need to create a ALSPAC proposal: o Ensure you have an account on the system and that the contact email address is from your institutional email and matches the one on your EGA data request. o Read the ALSPAC access policy (https://www.bristol.ac.uk/media-library/sites/alspac/documents/researchers/data-access/ALSPAC_Access_Policy.pdf) which describes the process of accessing the data and samples in detail, and outlines the costs associated with doing so. o Please include “EGA WES” in the project title. o A data access agreement (DAA) with ALSPAC is required before your access request can be approved. You can find more information about the agreements in the access policy. This has a cost associated with it, which can be found within the access policy. o Create and submit your proposal detailing the intended research. The proposal form must be completed in full. o Under the section: Exposures, outcomes and confounders to be considered (justifying particular types of data as necessary) please include the text: “We wish to access the whole exome sequencing data held at the EGA”. You can also list here if you want additional ALSPAC data. See costings for data released by ALSPAC in the access policy. - Once your proposal has been submitted, it will be reviewed by the ALSPAC executive and you will receive an outcome email within 10 days. - If approved, you will be assigned a data buddy who will provide a project specific version of the DAA for signing and will confirm the exact cost. - Once the DAA is fully signed (by both parties), we will grant access via EGA. We will aim to do this within 10 working days of the DAA being signed. If you require phenotypic data or other omics datasets, please indicate this on the project proposal. Be aware there is a version of the ALSPAC WES data which will be released via ALSPAC’s omics release system, so you may not need to use the EGA if you are requesting other omics datasets. If you require the EGA release of the dataset, but also phenotypic data, there will be a cost associated with linking the phenotypic data to the EGA dataset (£300 + VAT) in addition to the cost of providing the phenotypic data.