Oxidative phosphorylation is a key ontogenetic feature of monocyte immunometabolism promoting myeloid differentiation after birth
The dataset consists of 12 samples of monocytes, which were analyzed using RNA-sequencing (RNA-seq). These samples were categorized into four distinct groups, each comprising three samples. The dataset was designed to investigate the transcriptomic and metabolic profiles of monocytes across different age groups and stimulation conditions. 3 neonatal controls, 3 neonatal LPS stimulated, 3 adult controls and 3 adult LPS stimulated samples.
- 12 samples
- DAC: EGAC00001003420
- Technology: Illumina HiSeq 1500
Neonatal immune responses differ from adults. Neonatal monocytes rely on glycolysis for inflammation while maintaining high oxidative phosphorylation (OXPHOS) for differentiation. This metabolic pattern gradually changes in the first five years of life, with dietary changes unable to fully reverse it. Key regulators include E2F1, MYB, STAT1, and FLI1. This unique immunometabolism adapts gradually in response to childhood microbial challenges.
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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
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| Other |