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Enhanced Detection of Landmark Minimal Residual Disease in Lung Cancer using Cell-Free DNA Fragmentomics

The circulating tumor DNA (ctDNA) mutation-based approach shows limited performance in minimal residual disease (MRD) detection, especially for landmark MRD detection at an early-stage cancer after surgery. Here, A total of 87 NSCLC patients, who received curative surgical resections (23 patients relapsed during follow-up), enrolled in this study. A total of 163 plasma samples, collected at 7 days and 6 months postsurgical, were used for high-throughput sequencing.

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This agreement governs the terms on which access will be granted to the genotype data generated by Nanjing Medical University Affiliated Jiangsu Cancer Hospital

DATA ACCESS AGREEMENT 1. You agree to use the Data only for the advancement of medical research, according to the consent obtained from sample donors. 2. You agree to preserve, at all times, the confidentiality of information and Data pertaining to Data Subjects. In particular, You undertake not to use, or attempt to use the Data to compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy. 3. You agree not to attempt to link the data provided under this agreement to other information or archive data available for the data sets provided, even if access to that data has been formally granted to you, or it is freely available without restriction, without specific permission being sought from the relevent access committees. 4. You agree not to transfer or disclose the Data, in whole or part, or any identifiable material derived from the Data, to others, except as necessary for data/safety monitoring or programme management. Should You wish to share the Data with a collaborator out with the same Institution, the third party must make a separate application for access to the Data. 5. You agree to use the data for the approved purpose and project described in your application; use of the data for a new purpose or project will require a new application and approval. 6. You accept that Data will be reissued from time to time, with suitable versioning. If the reissue is at the request of sample donors and/or other ethical scrutiny, You will destroy earlier versions of the Data. 7. You accept that the Consortium, the original data creators, depositors or copyright holders, or the funders of the Data or any part of the Data supplied: a) bear no legal responsibility for the accuracy or comprehensiveness of the Data; and b) accept no liability for indirect, consequential, or incidental, damages or losses arising from use of the Data, or from the unavailability of, or break in access to, the Data for whatever reason. 8. You understand and acknowledge that the Data is protected by copyright and other intellectual property rights, and that duplication, except as reasonably required to carry out Your research with the Data, or sale of all or part of the Data on any media is not permitted. 9. You recognise that nothing in this agreement shall operate to transfer to the User Institution any intellectual property rights relating to the Data. The User Institution has the right to develop intellectual property based on comparisons with their own data. 10. You accept that this agreement will terminate immediately upon any breach of this agreement by You and You will be required to destroy any Data held. 11. You accept that it may be necessary for the Consortium or its appointed agent to alter the terms of this agreement from time to time in order to address new concerns. In this event, the Consortium or its appointed agent will contact You to inform You of any changes and You agree that Your continued use of the Data shall be dependent on the parties entering into a new version of the Agreement. 12. You agree that you will submit a report to the Consortium Data Access Committee, if requested, on completion of the agreed purpose. The Consortium Data Access Committee agrees to treat the report and all information, data, results, and conclusions contained within such report as confidential information belonging to the User Institution.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001007192 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00008045082 bed 35.9 MB
EGAF00008045083 bed 38.3 MB
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EGAF00008045085 bed 30.5 MB
EGAF00008045086 bed 44.2 MB
EGAF00008045087 bed 37.7 MB
EGAF00008045088 bed 30.6 MB
EGAF00008045089 bed 48.8 MB
EGAF00008045090 bed 43.7 MB
EGAF00008045091 bed 38.9 MB
EGAF00008045092 bed 28.5 MB
EGAF00008045093 bed 33.9 MB
EGAF00008045094 bed 39.6 MB
EGAF00008045095 bed 51.2 MB
EGAF00008045096 bed 36.3 MB
EGAF00008045097 bed 42.2 MB
EGAF00008045098 bed 52.8 MB
EGAF00008045099 bed 27.1 MB
EGAF00008045100 bed 41.1 MB
EGAF00008045101 bed 42.2 MB
EGAF00008045102 bed 31.6 MB
EGAF00008045103 bed 35.1 MB
EGAF00008045104 bed 42.7 MB
EGAF00008045105 bed 44.9 MB
EGAF00008045106 bed 32.6 MB
EGAF00008045107 bed 39.6 MB
EGAF00008045108 bed 34.5 MB
EGAF00008045109 bed 47.7 MB
EGAF00008045110 bed 38.8 MB
EGAF00008045111 bed 34.3 MB
EGAF00008045112 bed 44.4 MB
EGAF00008045113 bed 33.3 MB
EGAF00008045114 bed 40.6 MB
EGAF00008045115 bed 36.6 MB
EGAF00008045116 bed 33.7 MB
EGAF00008045117 bed 29.3 MB
EGAF00008045118 bed 39.6 MB
EGAF00008045119 bed 35.1 MB
EGAF00008045120 bed 40.2 MB
EGAF00008045121 bed 36.1 MB
EGAF00008045122 bed 31.3 MB
EGAF00008045123 bed 41.2 MB
EGAF00008045124 bed 38.6 MB
EGAF00008045125 bed 47.3 MB
EGAF00008045126 bed 42.6 MB
EGAF00008045127 bed 36.9 MB
EGAF00008045128 bed 45.2 MB
EGAF00008045129 bed 37.3 MB
EGAF00008045130 bed 38.7 MB
EGAF00008045131 bed 38.3 MB
EGAF00008045132 bed 37.2 MB
EGAF00008045133 bed 37.4 MB
EGAF00008045134 bed 29.3 MB
EGAF00008045135 bed 47.8 MB
EGAF00008045136 bed 39.7 MB
EGAF00008045137 bed 41.4 MB
EGAF00008045138 bed 47.5 MB
EGAF00008045139 bed 47.3 MB
EGAF00008045140 bed 41.2 MB
EGAF00008045141 bed 35.9 MB
EGAF00008045142 bed 39.3 MB
EGAF00008045143 bed 35.7 MB
EGAF00008045144 bed 43.7 MB
EGAF00008045145 bed 38.6 MB
EGAF00008045146 bed 44.9 MB
EGAF00008045147 bed 53.2 MB
EGAF00008045148 bed 44.7 MB
EGAF00008045149 bed 29.6 MB
EGAF00008045150 bed 56.3 MB
EGAF00008045151 bed 32.5 MB
EGAF00008045152 bed 30.3 MB
EGAF00008045153 bed 51.4 MB
EGAF00008045154 bed 33.6 MB
EGAF00008045155 bed 38.8 MB
EGAF00008045156 bed 40.2 MB
EGAF00008045157 bed 47.6 MB
EGAF00008045158 bed 46.9 MB
EGAF00008045159 bed 49.5 MB
EGAF00008045160 bed 32.9 MB
EGAF00008045161 bed 33.1 MB
EGAF00008045162 bed 34.7 MB
EGAF00008045163 bed 32.8 MB
EGAF00008045164 bed 49.4 MB
EGAF00008045165 bed 44.2 MB
EGAF00008045166 bed 34.6 MB
EGAF00008045167 bed 44.1 MB
EGAF00008045168 bed 37.4 MB
EGAF00008045169 bed 37.4 MB
EGAF00008045170 bed 41.2 MB
EGAF00008045171 bed 40.9 MB
EGAF00008045172 bed 52.0 MB
EGAF00008045173 bed 39.2 MB
EGAF00008045174 bed 38.4 MB
EGAF00008045175 bed 36.8 MB
EGAF00008045176 bed 30.1 MB
EGAF00008045177 bed 36.8 MB
EGAF00008045178 bed 46.3 MB
EGAF00008045179 bed 34.9 MB
EGAF00008045180 bed 45.6 MB
EGAF00008045181 bed 40.8 MB
EGAF00008045182 bed 43.9 MB
EGAF00008045183 bed 29.5 MB
EGAF00008045184 bed 40.5 MB
EGAF00008045185 bed 48.9 MB
EGAF00008045186 bed 57.4 MB
EGAF00008045187 bed 48.6 MB
EGAF00008045188 bed 36.9 MB
EGAF00008045189 bed 40.6 MB
EGAF00008045190 bed 31.8 MB
EGAF00008045191 bed 65.2 MB
EGAF00008045192 bed 45.5 MB
EGAF00008045193 bed 40.7 MB
EGAF00008045194 bed 45.1 MB
EGAF00008045195 bed 35.9 MB
EGAF00008045196 bed 27.5 MB
EGAF00008045197 bed 52.1 MB
EGAF00008045198 bed 47.6 MB
EGAF00008045199 bed 38.5 MB
EGAF00008045200 bed 39.8 MB
EGAF00008045201 bed 34.6 MB
EGAF00008045202 bed 54.4 MB
EGAF00008045203 bed 55.1 MB
EGAF00008045204 bed 32.7 MB
EGAF00008045205 bed 36.3 MB
EGAF00008045206 bed 49.7 MB
EGAF00008045207 bed 51.6 MB
EGAF00008045208 bed 34.6 MB
EGAF00008045209 bed 44.1 MB
EGAF00008045210 bed 50.1 MB
EGAF00008045211 bed 41.3 MB
EGAF00008045212 bed 46.0 MB
EGAF00008045213 bed 72.6 MB
EGAF00008045214 bed 47.7 MB
EGAF00008045215 bed 65.3 MB
EGAF00008045216 bed 51.0 MB
EGAF00008045217 bed 45.1 MB
EGAF00008045218 bed 36.8 MB
EGAF00008045219 bed 66.8 MB
EGAF00008045220 bed 33.6 MB
EGAF00008045221 bed 34.2 MB
EGAF00008045222 bed 48.4 MB
EGAF00008045223 bed 46.7 MB
EGAF00008045224 bed 26.9 MB
EGAF00008045225 bed 35.7 MB
EGAF00008045226 bed 46.6 MB
EGAF00008045227 bed 38.0 MB
EGAF00008045228 bed 45.2 MB
EGAF00008045229 bed 38.4 MB
EGAF00008045230 bed 49.6 MB
EGAF00008045231 bed 49.9 MB
EGAF00008045232 bed 54.6 MB
EGAF00008045233 bed 41.0 MB
EGAF00008045234 bed 30.0 MB
EGAF00008045235 bed 36.1 MB
EGAF00008045236 bed 49.2 MB
EGAF00008045237 bed 41.7 MB
EGAF00008045238 bed 40.4 MB
EGAF00008045239 bed 31.6 MB
EGAF00008045240 bed 42.6 MB
EGAF00008045241 bed 55.9 MB
EGAF00008045242 bed 40.8 MB
EGAF00008045243 bed 53.8 MB
EGAF00008045244 bed 65.9 MB
163 Files (6.8 GB)