Need Help?

Single cell epigenomic study of H3-K27M mutant diffuse midline glioma across age and location

This dataset contains the open chromatin profiles of 8 patient H3-K27M mutant DMGs utilizing the single-cell/nucleus assay for transposase-accessible chromatin using sequencing (snATAC-seq)

Request Access

Policy for data access by the DMG DAC.

These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom the DMG DAC grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: DMG DAC and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. XXXXX: Your Institution details here 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify the DMG DAC within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify the DMG DAC prior to any significant changes to the protocol for the Project. 14. The User Institution will notify the DMG DAC as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. The DMG DAC may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than the DMG DAC. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of the US and shall be subject to the exclusive jurisdiction of the US courts. Agreed for User Institution Signature: Name: Title: Date: Principal Investigator I confirm that I have read and understood this Agreement. Signature: Name: Title: Date: Agreed for DMG DAC Signature: Name: Title: Date: APPENDIX I – DATASET DETAILS APPENDIX II ––PROJECT DETAILS APPENDIX III –– PUBLICATION POLICY APPENDIX I – DATASET DETAILS (to be completed by the data producer before passing to applicant) Dataset reference (EGA Study ID and Dataset Details) Name of project that created the dataset Names of other data producers/collaborators Specific limitations on areas of research Minimum protection measures required File access: Data can be held in unencrypted files on an institutional compute system, with Unix user group read/write access for one or more appropriate groups but not Unix world read/write access behind a secure firewall. Laptops holding these data should have password protected logins and screenlocks (set to lock after 5 min of inactivity). If held on USB keys or other portable hard drives, the data must be encrypted. APPENDIX II – PROJECT DETAILS (to be completed by the Requestor) Details of dataset requested i.e., EGA Study and Dataset Accession Number Brief abstract of the Project in which the Data will be used (500 words max) All Individuals who the User Institution to be named as registered users Name of Registered User Email Job Title Supervisor* All Individuals that should have an account created at the EGA Name of Registered User Email Job Title APPENDIX III – PUBLICATION POLICY In any publications based on these data, please describe how the data can be accessed, including the name of the hosting database (e.g., The European Genome-phenome Archive at the European Bioinformatics Institute) and its accession numbers (e.g., EGAS00000000029), and acknowledge its use in a form agreed by the User Institution with the DMG DAC.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001007035 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00007955758 fastq.gz 1.5 GB
EGAF00007964074 fastq.gz 400.3 MB
EGAF00007964075 fastq.gz 956.6 MB
EGAF00007964076 fastq.gz 1.5 GB
EGAF00007964077 fastq.gz 1.4 GB
EGAF00007964078 fastq.gz 919.8 MB
EGAF00007964079 fastq.gz 1.5 GB
EGAF00007964080 fastq.gz 408.8 MB
EGAF00007964081 fastq.gz 1.5 GB
EGAF00007964082 fastq.gz 962.4 MB
EGAF00007964083 fastq.gz 1.5 GB
EGAF00007964084 fastq.gz 396.8 MB
EGAF00007964085 fastq.gz 1.4 GB
EGAF00007964086 fastq.gz 931.1 MB
EGAF00007964087 fastq.gz 1.5 GB
EGAF00007964088 fastq.gz 273.5 MB
EGAF00007964089 fastq.gz 989.1 MB
EGAF00007964090 fastq.gz 645.4 MB
EGAF00007964091 fastq.gz 999.1 MB
EGAF00007964092 fastq.gz 268.7 MB
EGAF00007964093 fastq.gz 960.4 MB
EGAF00007964094 fastq.gz 629.1 MB
EGAF00007964095 fastq.gz 973.1 MB
EGAF00007964096 fastq.gz 275.2 MB
EGAF00007964097 fastq.gz 649.2 MB
EGAF00007964098 fastq.gz 1.0 GB
EGAF00007964099 fastq.gz 266.8 MB
EGAF00007964100 fastq.gz 955.2 MB
EGAF00007964101 fastq.gz 626.1 MB
EGAF00007964102 fastq.gz 967.2 MB
EGAF00007964595 fastq.gz 235.0 MB
EGAF00007964596 fastq.gz 812.4 MB
EGAF00007964597 fastq.gz 532.0 MB
EGAF00007964598 fastq.gz 836.0 MB
EGAF00007964599 fastq.gz 229.2 MB
EGAF00007964600 fastq.gz 784.4 MB
EGAF00007964601 fastq.gz 515.0 MB
EGAF00007964602 fastq.gz 808.5 MB
EGAF00007964603 fastq.gz 236.8 MB
EGAF00007964604 fastq.gz 813.0 MB
EGAF00007964605 fastq.gz 534.5 MB
EGAF00007964606 fastq.gz 838.3 MB
EGAF00007964607 fastq.gz 233.6 MB
EGAF00007964608 fastq.gz 793.3 MB
EGAF00007964609 fastq.gz 523.1 MB
EGAF00007964610 fastq.gz 820.2 MB
EGAF00007964611 fastq.gz 386.7 MB
EGAF00007964612 fastq.gz 994.9 MB
EGAF00007965363 fastq.gz 355.8 MB
EGAF00007965364 fastq.gz 1.3 GB
EGAF00007965365 fastq.gz 850.3 MB
EGAF00007965366 fastq.gz 1.3 GB
EGAF00007965367 fastq.gz 348.8 MB
EGAF00007965368 fastq.gz 1.3 GB
EGAF00007965369 fastq.gz 824.9 MB
EGAF00007965370 fastq.gz 1.3 GB
EGAF00007965371 fastq.gz 360.6 MB
EGAF00007965372 fastq.gz 1.3 GB
EGAF00007965373 fastq.gz 855.7 MB
EGAF00007965374 fastq.gz 1.4 GB
EGAF00007965375 fastq.gz 357.5 MB
EGAF00007965376 fastq.gz 1.3 GB
EGAF00007965377 fastq.gz 839.3 MB
EGAF00007965378 fastq.gz 1.3 GB
EGAF00007965379 fastq.gz 185.4 MB
EGAF00007965380 fastq.gz 630.6 MB
EGAF00007965381 fastq.gz 411.7 MB
EGAF00007965382 fastq.gz 636.4 MB
EGAF00007965383 fastq.gz 182.0 MB
EGAF00007965384 fastq.gz 612.2 MB
EGAF00007965385 fastq.gz 401.2 MB
EGAF00007965386 fastq.gz 620.1 MB
EGAF00007965387 fastq.gz 186.8 MB
EGAF00007965388 fastq.gz 635.1 MB
EGAF00007965389 fastq.gz 414.7 MB
EGAF00007965390 fastq.gz 641.9 MB
EGAF00007965391 fastq.gz 180.8 MB
EGAF00007965392 fastq.gz 608.6 MB
EGAF00007965393 fastq.gz 398.9 MB
EGAF00007965394 fastq.gz 616.2 MB
EGAF00007969556 fastq.gz 290.7 MB
EGAF00007969557 fastq.gz 1.0 GB
EGAF00007969558 fastq.gz 687.2 MB
EGAF00007969559 fastq.gz 1.1 GB
EGAF00007969560 fastq.gz 284.1 MB
EGAF00007969561 fastq.gz 1.0 GB
EGAF00007969562 fastq.gz 664.8 MB
EGAF00007969563 fastq.gz 1.0 GB
EGAF00007969564 fastq.gz 294.6 MB
EGAF00007969565 fastq.gz 1.0 GB
EGAF00007969566 fastq.gz 691.4 MB
EGAF00007969567 fastq.gz 1.1 GB
EGAF00007969568 fastq.gz 291.5 MB
EGAF00007969569 fastq.gz 1.0 GB
EGAF00007969570 fastq.gz 677.1 MB
EGAF00007969571 fastq.gz 1.1 GB
EGAF00007969572 fastq.gz 21.9 MB
EGAF00007969573 fastq.gz 69.6 MB
EGAF00007969574 fastq.gz 46.1 MB
EGAF00007969575 fastq.gz 70.1 MB
EGAF00007969576 fastq.gz 21.3 MB
EGAF00007969577 fastq.gz 67.2 MB
EGAF00007969578 fastq.gz 44.6 MB
EGAF00007969579 fastq.gz 67.8 MB
EGAF00007969580 fastq.gz 22.0 MB
EGAF00007969581 fastq.gz 70.0 MB
EGAF00007969582 fastq.gz 46.3 MB
EGAF00007969583 fastq.gz 70.6 MB
EGAF00007969584 fastq.gz 21.1 MB
EGAF00007969585 fastq.gz 66.7 MB
EGAF00007969586 fastq.gz 44.3 MB
EGAF00007969587 fastq.gz 67.4 MB
EGAF00007973358 fastq.gz 355.1 MB
EGAF00007973359 fastq.gz 1.3 GB
EGAF00007973360 fastq.gz 845.1 MB
EGAF00007973361 fastq.gz 1.3 GB
EGAF00007973362 fastq.gz 348.1 MB
EGAF00007973363 fastq.gz 1.3 GB
EGAF00007973364 fastq.gz 821.9 MB
EGAF00007973365 fastq.gz 1.3 GB
EGAF00007973366 fastq.gz 357.1 MB
EGAF00007973367 fastq.gz 1.3 GB
EGAF00007973368 fastq.gz 849.4 MB
EGAF00007973369 fastq.gz 1.3 GB
EGAF00007973370 fastq.gz 345.7 MB
EGAF00007973371 fastq.gz 1.2 GB
EGAF00007973372 fastq.gz 817.5 MB
EGAF00007973373 fastq.gz 1.3 GB
EGAF00007973374 fastq.gz 515.7 MB
EGAF00007973375 fastq.gz 1.9 GB
EGAF00007973376 fastq.gz 1.2 GB
EGAF00007973377 fastq.gz 1.9 GB
EGAF00007973378 fastq.gz 500.2 MB
EGAF00007973379 fastq.gz 1.8 GB
EGAF00007973380 fastq.gz 1.2 GB
EGAF00007973381 fastq.gz 1.9 GB
EGAF00007973382 fastq.gz 528.8 MB
EGAF00007973383 fastq.gz 1.9 GB
EGAF00007973384 fastq.gz 1.2 GB
EGAF00007973385 fastq.gz 2.0 GB
EGAF00007973386 fastq.gz 513.5 MB
EGAF00007973387 fastq.gz 1.8 GB
EGAF00007973388 fastq.gz 1.2 GB
EGAF00007973389 fastq.gz 1.9 GB
144 Files (110.8 GB)