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Timing chromosomal amplification events using patterns of somatic mutations in high hyperdiploid acute lymphoblastic leukemia

This dataset included 19 paired diagnostic and remission samples with high hyperdiploid acute lymphoblastic leukemia (ALL) that were collected from four different cohorts: the Division of Clinical Genetics, Lund University, Sweden. All samples were subjected to whole genome sequencing using the Illumina HiSeqX platform. Paired-end sequencing (2x150bp) was done to ~60x coverage for diagnostic samples and ~30x coverage for remission samples. The paired-end reads were aligned to the human reference genome GRCh37 (ftp://ftp.ncbi.nlm.nih.gov/genomes/refseq/vertebrate_mammalian/Homo_sapiens/all_assembly_versions/GCF_000001405.25_GRCh37.p13/GCF_000001405.25_GRCh37.p13_genomic.fna.gz) by the Burrows-Wheeler Aligner tool (version 0.7.17). Duplicate reads marking and local realignment were performed by GATK (version 4.0.11.0).

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Access to individual-level genotype data is available by application to the High hyperdiploid ALL bulk DNA sequencing data Data Access Committee

DATA ACCESS AGREEMENT between Lund University, P. O. Box 117, SE-221 00 Lund, Sweden, (hereinafter referred to as the “University”); and [name], [address], (hereinafter referred to as the “Recipient”); each a ‘Party’ and together the ‘Parties’. This agreement (the “Agreement”) is made on the last day of signature here below (the “Agreement Date”). BACKGROUND (A) The University’s Department of Laboratory Medicine, Division of Clinical Genetics is the owner of human genetic data relating to the research article by Woodward et al. regarding clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukemia, for which the University has received approval from the Regional Ethics Committee (Regionala Etikprövningsnämnden) under the permission number Dnr 2011/289, updated 2017/796 (B) Pursuant to the request by the Recipient, the University has agreed to make the Data available to it for research purposes. OPERATIVE TERMS 1 Definitions and Interpretation 1.1 “User” means a researcher (or an individual conducting Research under the supervision of a researcher) who is employed by the Recipient and is bound by the terms and conditions of this Agreement. For the avoidance of doubt, “User” may also include students, visiting academics, contractors, sub-contractors or independent consultants provided that any such individual is bound by obligations no less onerous then those binding the Recipient’s employees. 1.2 ‘”Data” means the human genetic data obtained by the University. 1.3 “Data Subjects” means the individual to whom Data refers. 2 Access to Data 2.1 In consideration of the University agreeing to supply the Data to the Recipient, the Recipient agrees to be bound by the terms and conditions of this Agreement. The Recipient shall ensure that all Users are aware of and comply with the terms of the Agreement. 2.2 Recipient shall only use Data for the advancement of non-commercial biomedical research as specified in the data application form provided by the University and attached hereto as Appendix 1. 2.3 The Recipient agrees to only give access to Data, in whole or part, or any identifiable material derived from the Data, to Users. The Recipient agrees that before it gives any User access to Data, it shall first show the User a copy of this Agreement and shall inform the User that he or she must comply with the obligations contained in this Agreement and sign up to the provisions of this Agreement in the form set out at the end of this Agreement. The Recipient shall provide the University with a copy of the User’s acceptance form within thirty (30) days of the date of acceptance by the User. 2.4 The Recipient shall refer to the University all requests from third parties/persons not working under the direct supervision of the Recipient for supplies of the Data. 3 Data protection and confidentiality 3.1 Recipient agrees to comply with EU legislation on data protection when processing Data and to preserve, at all times, the confidentiality of the Data. Recipient further agrees to not attempt to identify the Data Subjects, redistribute the Data, or any subset or derivative of the Data, that could be used to identify the Data Subject, or in any other way compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy. 3.2 Where required under applicable laws regulating cross-border transfers of Personal Data, including European data protection laws, the parties, or their affiliates, will execute any further agreements or undertakings required to enable the lawful transfer of Personal Data, including where appropriate the EU standard contractual clauses for transfers of Personal Data to non-EU data processors set out in European Commission Decision 2010/87/EC of 5 February 2010 available at: http://eurlex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2010:039:0005:0018:EN:PDF or such standard contractual clauses as are then in force. 3.3 The Recipient agrees that it shall take all reasonable security precautions to keep the Data confidential, such precautions to be no less onerous than those applied in respect of the Recipient’s own confidential information. 4 Errors The Recipient agrees to notify the University of any errors detected in the Data. 5 Ownership of the Data 5.1 The Data and all intellectual property in them shall at all times remain the property of the University. 5.2 The Recipient and its Users shall have the right to develop Intellectual Property based on comparisons with their own data. Recipient and User recognise that nothing in this agreement shall operate to transfer to the Recipient any intellectual property rights relating to the Data. 6 Publications and reporting 6.1 The Recipient agrees to acknowledge in any work based in whole or part on the Data, the published paper from which the Data derives, the version of the Data, and the role of the University in its distribution. The Recipient will also declare in any such work that those who carried out the original analysis and collection of the Data bear no responsibility for the further analysis or interpretation of it by the Recipient. The Recipient undertakes that the Data and Confidential Information will only be used by the Recipient and Users for the sole purpose of the academic research and will not be used for any commercial purpose or commercially sponsored research. 6.2 The Recipient agrees to follow the Publication Policy in Appendix I. This includes respecting the moratorium period for the University to publish the first peer-reviewed report describing and analysing the Data. 7 Warranties 7.1 The Recipient accepts and agrees that the Data are experimental in nature and that they are supplied by the University on an ‘as is’ basis. The University makes no representation and gives no warranty or undertaking in relation to them whatsoever and excludes all implied warranties to the fullest extent permitted by law; 7.2 In particular, the University makes no representations or warranties, express or implied: • as to title, quality or fitness for a particular purpose or use of the Data; or • that the supply by the University or the use by the Recipient of the Data will not infringe the intellectual property rights of any third party. 7.3 The Recipient warrants that, in relation to the Data and their use: • they will comply with all relevant legislation and regulations; and • they have obtained all necessary consents and ethical approvals. 8 Liability 8.1 The University accepts no liability for loss of data, loss of profit, business or goodwill and all other indirect or consequential loss or damage suffered or incurred by the Recipient or by any other person arising from the supply of the Data or the use, keeping, or disposal of the Data. 8.2 The Recipient shall defend, indemnify and hold the University, its officers, employees and agents harmless against any loss, claim, damage or liability including reasonable legal costs and fees (of whatsoever kind or nature) which may arise in connection with the Recipient’s breach of this Agreement or the use, keeping, production or disposal of the Recipient or on its behalf, unless caused by the University’s gross negligence or wilful act or omission. 9 Termination 9.1 This Agreement shall take effect from the Agreement Date and will terminate on a Party giving 30 days’ prior written notice to the other; or upon breach by the Recipient or Users of any of the terms of this Agreement. 9.2 Upon termination of this Agreement or upon service of notice of termination by a Party for any reason whatsoever, the Recipient shall discontinue its use of the Data and shall, in accordance with the directions of the University, at its own cost and expense destroy the Data or return it to the University. 10 Notices 10.1 The Recipient will do all such acts and execute such documents as are required by the University to give effect to the terms of this Agreement or to enable the University to enjoy the full benefit of this Agreement (including but not limited to ownership of the Data and the arising intellectual property). 10.2 Recipient accepts that it may be necessary for the University or its appointed agent to alter the terms of this Agreement from time to time in order to address new concerns. In this event, the University or its appointed agent will contact Recipient to inform Recipient of any changes and Recipient agrees that Recipient’s continued use of the Data shall be dependent on the parties entering into a new version of the Agreement. 10.3 The Recipient may not assign or transfer all or any of its rights or obligations under this Agreement without the prior written consent of the University. 10.4 This Agreement is subject to Swedish substantive law. 10.5 Any dispute, controversy or claim arising out of or in connection with this Agreement, or the breach, termination or invalidity thereof, shall be solved by Swedish courts. This Agreement has been drawn up in two (2) original copies, each Party receiving one duly signed copy thereof. Signed …………………………….. Signed ……………………………… Authorised signature for and on behalf of Lund University Authorised signature for and on behalf of Recipient [please fill in the name of recipient] Name Name Position Position Dated Dated For the User (s):I acknowledge that I have read and understand the terms of this Agreement Signed ……………………………… Name Position Dated APPENDIX I –– PUBLICATION POLICY   APPENDIX I –– PUBLICATION POLICY The University intend to publish the results of their analysis of this dataset and do not consider its deposition into public databases to be the equivalent of such publications. The University anticipate that the dataset could be useful to other qualified researchers for a variety of purposes. However, some areas of work are subject to a publication moratorium. The publication moratorium covers any publications (including oral communications) that describe the use of the Data. For research papers, submission for publication should not occur until twelve (12) months after the Data were first made available on the relevant hosting database.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001007052 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00007959266 cram 60.9 GB
EGAF00007959267 cram 46.7 GB
EGAF00007959268 cram 24.8 GB
EGAF00007959269 cram 36.2 GB
EGAF00007959270 cram 21.6 GB
EGAF00007959271 cram 69.4 GB
EGAF00007959272 cram 48.6 GB
EGAF00007959273 cram 36.8 GB
EGAF00007959274 cram 18.8 GB
EGAF00007959275 cram 31.6 GB
EGAF00007959276 cram 67.2 GB
EGAF00007959277 cram 32.2 GB
EGAF00007959278 cram 29.9 GB
EGAF00007959279 cram 26.5 GB
EGAF00007959280 cram 82.4 GB
EGAF00007959281 cram 38.8 GB
EGAF00007959282 cram 61.1 GB
EGAF00007959283 cram 28.5 GB
EGAF00007959284 cram 60.1 GB
EGAF00007959285 cram 24.8 GB
EGAF00007959286 cram 62.1 GB
EGAF00007959287 cram 33.5 GB
EGAF00007959288 cram 61.1 GB
EGAF00007959289 cram 26.0 GB
EGAF00007959290 cram 64.9 GB
EGAF00007959291 cram 29.9 GB
EGAF00007959292 cram 94.9 GB
EGAF00007959293 cram 47.3 GB
EGAF00007959294 cram 38.4 GB
EGAF00007959295 cram 28.5 GB
EGAF00007959296 cram 32.4 GB
EGAF00007959297 cram 14.2 GB
EGAF00007959298 cram 63.7 GB
EGAF00007959299 cram 39.5 GB
EGAF00007959300 cram 62.4 GB
EGAF00007959301 cram 34.1 GB
EGAF00007959302 cram 67.3 GB
EGAF00007959303 cram 36.6 GB
EGAF00007959304 crai 1.8 MB
EGAF00007959305 crai 1.4 MB
EGAF00007959306 crai 1.7 MB
EGAF00007959307 crai 3.5 MB
EGAF00007959308 crai 3.3 MB
EGAF00007959309 crai 1.8 MB
EGAF00007959310 crai 1.4 MB
EGAF00007959311 crai 2.5 MB
EGAF00007959312 crai 1.7 MB
EGAF00007959313 crai 3.1 MB
EGAF00007959314 crai 4.2 MB
EGAF00007959315 crai 3.3 MB
EGAF00007959316 crai 1.3 MB
EGAF00007959317 crai 3.4 MB
EGAF00007959318 crai 2.0 MB
EGAF00007959319 crai 3.3 MB
EGAF00007959320 crai 1.9 MB
EGAF00007959321 crai 2.1 MB
EGAF00007959322 crai 3.2 MB
EGAF00007959323 crai 1.7 MB
EGAF00007959324 crai 1.7 MB
EGAF00007959325 crai 2.9 MB
EGAF00007959326 crai 1.8 MB
EGAF00007959327 crai 3.1 MB
EGAF00007959328 crai 1.5 MB
EGAF00007959329 crai 3.4 MB
EGAF00007959330 crai 3.2 MB
EGAF00007959331 crai 1.5 MB
EGAF00007959332 crai 3.3 MB
EGAF00007959333 crai 3.3 MB
EGAF00007959334 crai 2.7 MB
EGAF00007959335 crai 1.7 MB
EGAF00007959336 crai 3.3 MB
EGAF00007959337 crai 3.3 MB
EGAF00007959338 crai 3.3 MB
EGAF00007959339 crai 1.7 MB
EGAF00007959340 crai 1.7 MB
EGAF00007959341 crai 1.7 MB
76 Files (1.7 TB)