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WES and RNAseq of Simultaneous Bilateral Breast Cancer

This dataset includes NGS profiling of 13 women with simultaneous bilateral breast cancer. Seven women have WES of untreated surgical resections and matched healthy tissue. The six other women have WES of healthy tissue, WES+RNAseq of pre-neoadjuvant tumor biopsies, and when residual disease was present (6 tumors in 4 patients), WES+RNAseq of residual disease from post-neoadjuvant therapy surgery. One patient from the WES+RNAseq cohort had multifocal bilateral disease at diagnosis so there are 2 pre-neoadjuvant biopsy samples from each breast.

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The data may only be used for research purposes and confidentiality of the data and the research participants must be preserved at all times.

1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the 3 Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify Institut Curie within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify Institut Curie prior to any significant changes to the protocol for the Project. 14. The User Institution will notify Institut Curie as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. Institut Curie may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than Institut Curie. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of France and shall be subject to the exclusive jurisdiction of the French courts.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001006910 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00007902938 fastq.gz 4.1 GB
EGAF00007902939 fastq.gz 4.1 GB
EGAF00007902940 fastq.gz 4.2 GB
EGAF00007902941 fastq.gz 4.1 GB
EGAF00007902942 fastq.gz 4.7 GB
EGAF00007902943 fastq.gz 4.7 GB
EGAF00007902944 fastq.gz 6.9 GB
EGAF00007902945 fastq.gz 6.9 GB
EGAF00007902946 fastq.gz 6.2 GB
EGAF00007902947 fastq.gz 6.2 GB
EGAF00007902948 fastq.gz 7.5 GB
EGAF00007902949 fastq.gz 7.5 GB
EGAF00007902950 fastq.gz 6.6 GB
EGAF00007902951 fastq.gz 6.6 GB
EGAF00007902952 fastq.gz 6.9 GB
EGAF00007902953 fastq.gz 6.8 GB
EGAF00007902954 fastq.gz 7.2 GB
EGAF00007902955 fastq.gz 7.2 GB
EGAF00007902956 fastq.gz 5.7 GB
EGAF00007902957 fastq.gz 5.7 GB
EGAF00007902958 fastq.gz 7.6 GB
EGAF00007902959 fastq.gz 7.5 GB
EGAF00007902960 fastq.gz 6.7 GB
EGAF00007902961 fastq.gz 6.7 GB
EGAF00007902962 fastq.gz 6.9 GB
EGAF00007902963 fastq.gz 6.8 GB
EGAF00007902964 fastq.gz 6.8 GB
EGAF00007902965 fastq.gz 6.8 GB
EGAF00007902966 fastq.gz 7.1 GB
EGAF00007902967 fastq.gz 7.1 GB
EGAF00007902968 fastq.gz 7.7 GB
EGAF00007902969 fastq.gz 7.7 GB
EGAF00007902970 fastq.gz 6.9 GB
EGAF00007902971 fastq.gz 6.8 GB
EGAF00007902972 fastq.gz 6.4 GB
EGAF00007902973 fastq.gz 6.2 GB
EGAF00007902974 fastq.gz 6.7 GB
EGAF00007902975 fastq.gz 6.7 GB
EGAF00007902976 fastq.gz 6.8 GB
EGAF00007902977 fastq.gz 6.8 GB
EGAF00007902978 fastq.gz 5.8 GB
EGAF00007902979 fastq.gz 6.0 GB
EGAF00007902980 fastq.gz 5.5 GB
EGAF00007902981 fastq.gz 5.6 GB
EGAF00007902982 fastq.gz 5.0 GB
EGAF00007902983 fastq.gz 5.1 GB
EGAF00007902984 fastq.gz 2.2 GB
EGAF00007902985 fastq.gz 2.2 GB
EGAF00007902986 fastq.gz 7.3 GB
EGAF00007902987 fastq.gz 7.5 GB
EGAF00007902988 fastq.gz 4.8 GB
EGAF00007902989 fastq.gz 4.8 GB
EGAF00007902990 fastq.gz 3.5 GB
EGAF00007902991 fastq.gz 3.5 GB
EGAF00007902992 fastq.gz 7.2 GB
EGAF00007902993 fastq.gz 7.3 GB
EGAF00007902994 fastq.gz 7.5 GB
EGAF00007902995 fastq.gz 7.6 GB
EGAF00007902996 fastq.gz 4.8 GB
EGAF00007902997 fastq.gz 4.8 GB
EGAF00007902998 fastq.gz 3.8 GB
EGAF00007902999 fastq.gz 3.9 GB
EGAF00007903000 fastq.gz 5.6 GB
EGAF00007903001 fastq.gz 5.7 GB
EGAF00007903002 fastq.gz 7.3 GB
EGAF00007903003 fastq.gz 7.4 GB
EGAF00007903004 fastq.gz 4.6 GB
EGAF00007903005 fastq.gz 4.7 GB
EGAF00007903006 fastq.gz 4.2 GB
EGAF00007903007 fastq.gz 4.3 GB
EGAF00007903008 fastq.gz 10.8 GB
EGAF00007903009 fastq.gz 11.1 GB
EGAF00007903010 fastq.gz 5.0 GB
EGAF00007903011 fastq.gz 5.0 GB
EGAF00007903012 fastq.gz 5.9 GB
EGAF00007903013 fastq.gz 6.0 GB
EGAF00007903014 fastq.gz 6.4 GB
EGAF00007903015 fastq.gz 6.5 GB
EGAF00007903016 fastq.gz 4.1 GB
EGAF00007903017 fastq.gz 4.2 GB
EGAF00007903018 fastq.gz 5.8 GB
EGAF00007903019 fastq.gz 5.9 GB
EGAF00007903020 fastq.gz 3.7 GB
EGAF00007903021 fastq.gz 3.8 GB
EGAF00007903022 fastq.gz 4.6 GB
EGAF00007903023 fastq.gz 4.7 GB
EGAF00007903024 fastq.gz 3.8 GB
EGAF00007903025 fastq.gz 3.8 GB
EGAF00007903026 fastq.gz 6.9 GB
EGAF00007903027 fastq.gz 7.0 GB
EGAF00007903028 fastq.gz 7.6 GB
EGAF00007903029 fastq.gz 7.7 GB
EGAF00007903030 fastq.gz 3.0 GB
EGAF00007903031 fastq.gz 3.0 GB
EGAF00007903032 fastq.gz 3.3 GB
EGAF00007903033 fastq.gz 3.4 GB
EGAF00007903034 fastq.gz 9.4 GB
EGAF00007903035 fastq.gz 9.5 GB
EGAF00007903036 fastq.gz 2.8 GB
EGAF00007903037 fastq.gz 2.9 GB
EGAF00007903038 fastq.gz 6.2 GB
EGAF00007903039 fastq.gz 6.3 GB
EGAF00007903040 fastq.gz 8.3 GB
EGAF00007903041 fastq.gz 8.4 GB
EGAF00007903042 fastq.gz 4.2 GB
EGAF00007903043 fastq.gz 4.3 GB
EGAF00007903044 fastq.gz 3.7 GB
EGAF00007903045 fastq.gz 3.8 GB
EGAF00007903046 fastq.gz 4.3 GB
EGAF00007903047 fastq.gz 4.4 GB
EGAF00007903048 fastq.gz 4.1 GB
EGAF00007903049 fastq.gz 4.1 GB
EGAF00007903050 fastq.gz 1.1 GB
EGAF00007903051 fastq.gz 1.1 GB
EGAF00007903052 fastq.gz 1.4 GB
EGAF00007903053 fastq.gz 1.4 GB
EGAF00007903054 fastq.gz 1.1 GB
EGAF00007903055 fastq.gz 1.2 GB
EGAF00007903056 fastq.gz 4.6 GB
EGAF00007903057 fastq.gz 4.7 GB
EGAF00007903058 fastq.gz 4.7 GB
EGAF00007903059 fastq.gz 4.7 GB
EGAF00007903060 fastq.gz 2.9 GB
EGAF00007903061 fastq.gz 2.9 GB
EGAF00007903062 fastq.gz 3.6 GB
EGAF00007903063 fastq.gz 3.8 GB
EGAF00007903064 fastq.gz 6.3 GB
EGAF00007903065 fastq.gz 6.4 GB
EGAF00007903066 fastq.gz 5.8 GB
EGAF00007903067 fastq.gz 6.0 GB
EGAF00007903068 fastq.gz 2.5 GB
EGAF00007903069 fastq.gz 2.6 GB
EGAF00007903070 fastq.gz 1.1 GB
EGAF00007903071 fastq.gz 1.1 GB
134 Files (719.1 GB)