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Postmortem Single Nuclei and Bulk RNA-seq data of the Motor Cortex and Spinal Cord for Healthy, C9ALS and sALS Patients

This dataset contains both snRNA-seq and bulk RNA-seq data from 19 different patients, comprising of 9 healthy controls (4 Spinal Cord, 5 Motor Cortex) as well as 5 C9ALS patients and 5 sporadic ALS patients, each with paired data from the spinal cord and motor cortex. For the snRNA-seq data, fastq files containing the raw reads are provided, many of these samples were pooled for sequencing and subsequently require demultiplexing using SNPs using a tool such as freemuxlet. The paired bulk RNA-seq data (raw fastq files) can be used to acquire the ground truth per patient - a list of pooled samples can be found in map.txt. snRNA-seq data was produced using the 10X Genomics 3' v3 kit and bulk RNA-seq was produced using the Illumina TruSeq v2 kit.

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VIB Policy for Data Access and Data Transfer

Applicability This policy applies to the access to and transfer of VIB research datasets that contain non-anonymous Personal Data which are subject to the provisions of the General Data Protection Regulation (EU) 2016/679. Access/transfer conditions - The access/transfer is subject to approval by the VIB Data Access Committee. - The proposed research purpose should not be incompatible with the primary research purpose for which the data were originally generated. - The Recipient shall have in place adequate safeguards for the protection of Personal Data. - Access is subject to a Data Transfer/Access Agreement which will be managed by VIB Innovation & Business. - The Data Transfer/Access will be limited to the Data that are necessary for the proposed research. Access/transfer procedure - Requests to access or obtain non-anonymous datasets should be submitted to the responsible corresponding author that has uploaded the dataset into the repository, and with a copy to dac@vib.be. - The request should contain the following information: - Name, affiliation (legal entity) and contact information of the requesting recipient party. - Reference to the specific dataset(s) for which access or transfer is requested. - Description of the research purpose for which the data will be used. - The VIB Data Access Committee takes decisions to approve access/transfer within 14 days upon receipt of the request. - Data access will be given / Data will be transferred after completion of the Data Transfer/Access Agreement.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00007514206 1667264421027 11.2 GB
EGAF00007514207 1667264421027 26.5 GB
EGAF00007514208 1667262621760 5.1 GB
EGAF00007514209 1667263521144 11.6 GB
EGAF00007514210 1667263521144 5.2 GB
EGAF00007514211 1667263521144 11.9 GB
EGAF00007514212 1667263521144 5.9 GB
EGAF00007514213 1667263521144 13.7 GB
EGAF00007514214 1667262621760 6.4 GB
EGAF00007514215 1667263521144 14.7 GB
EGAF00007514216 1667262621760 4.5 GB
EGAF00007514217 1667263521144 10.8 GB
EGAF00007514218 1667264421027 13.4 GB
EGAF00007514219 1667265321010 31.7 GB
EGAF00007514220 1667262621760 4.6 GB
EGAF00007514221 1667262621760 11.1 GB
EGAF00007514222 1667262621760 7.7 GB
EGAF00007514223 1667264421027 17.9 GB
EGAF00007514224 1667262621760 7.2 GB
EGAF00007514225 1667264421027 16.7 GB
EGAF00007514226 1667262621760 7.6 GB
EGAF00007514227 1667264421027 17.5 GB
EGAF00007514228 1667263521144 7.8 GB
EGAF00007514229 1667264421027 18.3 GB
EGAF00007514230 1667263521144 7.4 GB
EGAF00007514231 1667264421027 17.3 GB
EGAF00007514232 1667262621760 3.4 GB
EGAF00007514233 1667263521144 7.7 GB
EGAF00007514234 1667263521144 5.2 GB
EGAF00007514235 1667263521144 11.9 GB
EGAF00007514236 1667262621760 1.2 GB
EGAF00007514237 1667261721806 1.1 GB
EGAF00007514238 1667261721806 1.1 GB
EGAF00007514239 1667261721806 1.2 GB
EGAF00007514240 1667261721806 1.2 GB
EGAF00007514241 1667261721806 1.2 GB
EGAF00007514242 1667262621760 1.1 GB
EGAF00007514243 1667261721806 893.2 MB
EGAF00007514244 1667261721806 1.1 GB
EGAF00007514245 1667261721806 1.0 GB
EGAF00007514246 1667261721806 1.2 GB
EGAF00007514247 1667261721806 914.6 MB
EGAF00007514248 1667261721806 875.6 MB
EGAF00007514249 1667261721806 931.8 MB
EGAF00007514250 1667261721806 1.2 GB
EGAF00007514251 1667261721806 1.1 GB
EGAF00007514252 1667261721806 1.0 GB
EGAF00007514253 1667261721806 935.3 MB
EGAF00007514254 1667261721806 1.1 GB
EGAF00007514255 1667262621760 3.8 GB
EGAF00007514256 1667262621761 8.7 GB
EGAF00007514257 1667262621761 3.2 GB
EGAF00007514258 1667262621761 7.5 GB
EGAF00007514259 1667262621761 3.5 GB
EGAF00007514260 1667262621761 8.2 GB
EGAF00007514261 1667262621760 3.0 GB
EGAF00007514262 1667262621760 6.9 GB
EGAF00007514263 1667261721806 1.9 GB
EGAF00007514264 1667262621760 4.3 GB
EGAF00007514265 1667262621760 4.2 GB
EGAF00007514266 1667263521144 9.4 GB
EGAF00007514267 1667261721806 2.2 kB
62 Files (426.9 GB)