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COVID-19 Postmortem Medulla and Olfactory Mucosa snRNA-seq

Time-dependent characterization of CNS response in COVID-19

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Data Transfer Agreement

Data Transfer Agreement between Charite - Universitätsmedizin Berlin Chariteplatz 1, 10117 Berlin Germany –hereinafter: „CHARITE“ – [INSERT INSTITUTION DETAILS full legal name and address] –hereinafter: „RECIPIENT“ – – individually referred to as “PARTY” and/or together referred to as “PARTIES” – Preamble This Data Transfer Agreement governs the terms on which access will be granted to the genotype data generated by CHARITE. 1.Definitions “Data” means all and any human genetic data obtained by the RECIPIENT from CHARITE. “Data Subject” means a person, to whom Data refers and who has been informed of the purposefor which the Data is held and has given her/his consent thereto. “Intellectual Property” means (i) patents, designs, trade marks and trade names (whetherregistered or unregistered), copyright and related rights, database rights, know-how andconfidential information; (ii) all other intellectual property rights and similar or equivalent rightsanywhere in the world which currently exist or are recognised in the future; and (iii) applications,extensions and renewals in relation to any such rights. “Publications” mean, without limitation, articles published in print journals, electronic journals,reviews, books, posters and other written and verbal presentation of research. “Registered User” means a researcher (or an individual conducting research under the supervision of a researcher) that is employed by the RECIPIENT and is bound by confidentiality and non-use obligations in respect of Data and who has signed this Agreement and has received acknowledgement of its acceptance. For the avoidance of doubt, “Registered User” may also include students, visiting academics, contractors, sub-contractors or independent consultants provided that any such individual is bound by confidentiality and non-use obligations no less onerous then those binding the RECIPIENT’s employees. 2.Obligations of the RECIPIENT 2.1 Confidentiality The RECIPIENT agrees to preserve, at all times, the confidentiality of Data pertaining to identifiable Data Subjects. In particular, the RECIPIENT undertakes not to use, or attempt to use the Data to deliberately compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy. 2.2 Data Protection 2.2.1 The RECIPIENT agrees to use the Data solely for the approved purpose and project described in the RECIPIENT’s application (Annex 1); use of the Data for a new purpose or project will require a new application and approval. 2.2.2 Data shall not be used for commercial purposes (e.g. diagnostic services). 2.2.3 The RECIPIENT, and her/his Registered Users, shall comply with the obligations contained in the applicable German and EU data protection laws and regulations as amended from time to time. 2.2.4 The RECIPIENT agrees that before he gives any Registered User access to Data, he shall first show the Registered User a copy of this Agreement and shall inform the Registered User that he or she must comply with the obligations contained in this Agreement and sign up to the provisions of this Agreement in the form set out at the end of this Agreement (Annex 2). The RECIPIENT shall provide CHARITE with a copy of the Registered User’s acceptance form within ten days of the date of acceptance by the Registered User. 2.2.5 The RECIPIENT agrees not to transfer or disclose the Data, in whole or in part, or any identifiable material derived from the Data, to others, except Registered Users. Should the RECIPIENT wish to share the Data with a collaborator out of the same institution, the third party must make a separate application for access to the Data. 2.2.6 The RECIPIENT agrees that she/he, and her/his Registered Users, shall not analyse or make any use of the Data in such a way that has the potential to: (i)lead to the re-identification of any Data Subject; or (ii)compromise the anonymity of any Data Subject in any way. 2.2.7 CHARITE reserves the right to request and inspect data security and management documentation to ensure the adequacy of data protection measures in countries that have no national laws comparable to that pertaining in the European Economic Area (EEA). 2.3 Data Security 2.3.1 The RECIPIENT agrees that she/he shall take all reasonable security precautions to keep the Data safe, such precautions to be no less onerous than in the applicable German and EU data protection laws and regulations. 2.3.2 The RECIPIENT shall adhere to the principle of IT-Security as set forth in Annex 3 hereto. 3.Provisions of cooperation 3.1 Errors The RECIPIENT agrees to notify CHARITE of any errors detected in the Data without undue delay. 3.2 Reissue of data The RECIPIENT accepts that CHARITE will reissue Data from time to time, with suitable versioning. If Data is reissued at the request of the Data Subject and/or as he result of other ethical scrutiny, the RECIPIENT agrees to destroy all earlier versions of the Data without undue delay once he has received such information. 3.3 Intellectual property 3.3.1 The RECIPIENT recognises that nothing in this Agreement shall operate to transfer to the RECIPIENT any intellectual property rights in or relating to the Data. 3.3.2 The RECIPIENT does not have the right to sublicense the Data. The RECEPIENT shall inform CHARITE about any third party requests for the Data. 3.3.3 The RECIPIENT shall have the right to develop intellectual property based on comparison with their own data. 3.3.4 CHARITE has no knowledge of any conflicting property rights of third parties regarding the provided Data. If CHARITE learns of potential conflicting property rights of third parties, CHARITE shall inform the RECIPIENT; however, no liability can be assumed for this. 3.4 Publications 3.4.1 The RECIPIENT agrees to acknowledge in any RECIPIENT’s work based in whole or part on the Date, any provider publications which encompass and from which Data derive, the respective version of the Data obtained, and the role of CHARITE. The RECIPIENT is also entitled to release publications and, in doing so, agrees to acknowledge any of CHARITE’s work based in whole or part on the Data in its publication. 3.4.2 The RECIPIENT will also declare in any such work that CHARITE and its employees bear no responsibility for the further analysis or interpretation of the Data by the RECIPIENT. 3.5 Liability 3.5.1 The RECIPIENT accepts that CHARITE, the original data creators, depositors or copyright holders, or the funders of the Data or any part of the Data supplied: (i)bear no legal responsibility for the accuracy or comprehensiveness of the Data; and (ii)accept no liability for indirect, consequential, or incidental, damages or losses arisingfrom use of the Data, or from the unavailability of, or break in access to, the Data forwhatever reason, except for damages caused intentionally or by gross negligence. 3.5.2 Nothing in this Agreement limits or excludes either Party’s liability for (i) product liability claims, (ii) death or personal injury resulting from negligence or any fraud or (iii) or in case of breaches of so called “material contractual obligations (Kardinalpflichten)”. Material contractual obligations (Kardinalpflichten) are obligations which principally enable the fulfilment of the proper enforcement of the contract and on which the contractual partner can trust and is allowed to trust for compliance (iiii) for any sort of other liability which by law cannot be limited or excluded according to applicable law. 4.General provisions 4.1 Termination of Agreement 4.1.1 This Agreement shall expire automatically three years after its signature by both PARTIES. 4.1.2 This Agreement will terminate immediately upon any breach of the provisions of this Agreement by the RECIPIENT. 4.1.3 The RECIPIENT accepts that the changing ethical framework of human genetic research may lead to: (i)alteration to the provisions of this Agreement, in which case the RECIPIENT may accept such alterations or terminate this Agreement; or (ii)the withdrawal of this Agreement in extreme circumstances.4.1.4 The notification of either PARTY to terminate this Agreement shall be made in writing with 4 weeks’ notice. 4.1.5 In the event that this Agreement is expired or terminated in accordance with this Clause 4.1 the RECIPIENT shall destroy all Data at the direction of CHARITE. This shall not apply to the extent that Data is saved in automatic back-up systems for which destruction shall follow the regular process of such back-up system, however, such Data shall be eliminated within a period of 90 days after the date of termination. Upon request of CHARITE, the RECIPIENT will certify the destruction of the Data. 4.2 Applicable Law 4.2.1 This Agreement shall be governed, construed and interpreted in accordance with the substantive laws of Germany. This Agreement shall be in the English language and the English version of this Agreement shall be deemed the official and governing instrument, notwithstanding any translations thereof. 4.2.2 The PARTIES agree to submit to the exclusive jurisdiction of the courts of Berlin, Germany, as regards any disputes, claims or matter arising under this Agreement. Annexes Annex 1 Application for Access to Genotype Data Annex 2 Declaration of commitment Annex 3 Data Security SIGNATURES for CHARITE ______________________ ______________________ Place, date, Anne Großkopff, Business Director Faculty for RECIPIENT ______________________ Place, date, _____________________ [Name ... ] Annex 1 Application for Access to Genotype Data Name of RECIPIENT and registered USERS, including affiliations and contact details. Enter the primary email correspondence email address you would like to use: Please ensure that a full postal and email address is included for the RECIPIENT and each registered USER. Title of Project (in less than 30 words) Data Request Research Question Please provide a clear description of the project and its specific aims in no more than 750 words. This should include specific details of what you plan to do with the data and include key references. Feasibiliy Please describe fully your experience and expertise, and that of your collaborators, and how this will be applied to the proposed study. Please send completed forms to: Charite - Universitätsmedizin Berlin BIH Digital Health Center Prof. Dr. Christian Conrad Kapelle-Ufer 2 10117 Berlin Germany Email: christian.conrad@charite.de Annex 2 Declaration of Commitment Please send signed form to: Charite - Universitätsmedizin Berlin BIH Digital Health Center Prof. Dr. Christian Conrad Kapelle-Ufer 2 10117 Berlin Germany Email: christian.conrad@charite.de I, __________________________________, declare that I will comply with the requirements of the Data Transfer Agreement as agreed upon between CHARITE and the RECIPIENT, including but not limited to the requirements of the applicable data protection regulations. With my signature I confirm the receipt of a copy of this agreement. ______________________ ______________________ Place, date, name Annex 3 Principle of IT-Security An appropriate level of data protection shall be ensured through appropriate technical and organisational measures: Guarantee of confidentiality Admission control No unauthorised access to data processing equipment, e.g: magnetic or chip cards, keys, electric door openers, plant security or gatekeepers, alarm systems, video systems Access control No unauthorized system use, e.g: (secure) passwords, automatic locking mechanisms, two-factor authentication, encryption of data carriers No unauthorized reading, copying, modification or removal within the system, e.g: authorization concepts and need-based access rights, logging of accesses Guarantee of integrity Transmission control No unauthorized reading, copying, modification or removal during electronic transmission or transport, e.g: encryption, Virtual Private Networks (VPN), electronic signature Input control Determination whether and by whom personal data have been entered, modified or removed from data processing systems, e.g: logging, document management Guarantee of the availability and resilience of the system Availability control Protection against accidental or deliberate destruction or loss, e.g: Backup strategy (online/offline; on-site/off-site), uninterruptible power supply (UPS), virus protection, firewall, reporting channels and emergency plans Rapid recoverability Procedures for regular review, assessment and evaluation Data protection management Incident response management Privacy friendly default settings The implementation shall take into account the state of the art, implementation costs and the nature, scale and purposes of the processing, as well as the varying degrees of probability and seriousness of the risk to the rights and freedoms of natural persons. The technical and organisational measures are subject to technical progress and further development.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001006442 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00006530576 fastq.gz 3.7 GB
EGAF00006530577 fastq.gz 7.5 GB
EGAF00006530578 fastq.gz 3.6 GB
EGAF00006530579 fastq.gz 7.4 GB
EGAF00006530580 fastq.gz 3.7 GB
EGAF00006530581 fastq.gz 7.5 GB
EGAF00006530582 fastq.gz 3.6 GB
EGAF00006530583 fastq.gz 7.4 GB
EGAF00006530584 fastq.gz 2.4 GB
EGAF00006530585 fastq.gz 3.8 GB
EGAF00006530586 fastq.gz 2.3 GB
EGAF00006530587 fastq.gz 3.6 GB
EGAF00006530588 fastq.gz 2.3 GB
EGAF00006530589 fastq.gz 3.6 GB
EGAF00006530590 fastq.gz 2.2 GB
EGAF00006530591 fastq.gz 3.4 GB
EGAF00006530592 fastq.gz 2.5 GB
EGAF00006530593 fastq.gz 4.2 GB
EGAF00006530594 fastq.gz 2.4 GB
EGAF00006530595 fastq.gz 4.1 GB
EGAF00006530596 fastq.gz 593.5 MB
EGAF00006530597 fastq.gz 1.2 GB
EGAF00006530598 fastq.gz 682.9 MB
EGAF00006530599 fastq.gz 1.4 GB
EGAF00006530600 fastq.gz 2.1 GB
EGAF00006530601 fastq.gz 4.4 GB
EGAF00006530602 fastq.gz 2.1 GB
EGAF00006530603 fastq.gz 4.4 GB
EGAF00006530604 fastq.gz 583.7 MB
EGAF00006530605 fastq.gz 1.2 GB
EGAF00006530606 fastq.gz 674.3 MB
EGAF00006530607 fastq.gz 1.4 GB
EGAF00006530608 fastq.gz 2.1 GB
EGAF00006530609 fastq.gz 4.3 GB
EGAF00006530610 fastq.gz 2.1 GB
EGAF00006530611 fastq.gz 4.4 GB
EGAF00006530612 fastq.gz 3.8 GB
EGAF00006530613 fastq.gz 8.5 GB
EGAF00006530614 fastq.gz 3.8 GB
EGAF00006530615 fastq.gz 8.4 GB
EGAF00006530616 fastq.gz 3.9 GB
EGAF00006530617 fastq.gz 8.5 GB
EGAF00006530618 fastq.gz 3.7 GB
EGAF00006530619 fastq.gz 8.3 GB
EGAF00006530620 fastq.gz 4.5 GB
EGAF00006530621 fastq.gz 9.8 GB
EGAF00006530622 fastq.gz 4.4 GB
EGAF00006530623 fastq.gz 9.7 GB
EGAF00006530624 fastq.gz 4.5 GB
EGAF00006530625 fastq.gz 9.8 GB
EGAF00006530626 fastq.gz 4.3 GB
EGAF00006530627 fastq.gz 9.5 GB
EGAF00006530628 fastq.gz 2.2 GB
EGAF00006530629 fastq.gz 5.0 GB
EGAF00006530630 fastq.gz 2.2 GB
EGAF00006530631 fastq.gz 4.9 GB
EGAF00006530632 fastq.gz 2.7 GB
EGAF00006530633 fastq.gz 6.1 GB
EGAF00006530634 fastq.gz 2.7 GB
EGAF00006530635 fastq.gz 6.1 GB
EGAF00006530636 fastq.gz 2.7 GB
EGAF00006530637 fastq.gz 6.1 GB
EGAF00006530638 fastq.gz 2.7 GB
EGAF00006530639 fastq.gz 6.0 GB
EGAF00006530640 fastq.gz 2.2 GB
EGAF00006530641 fastq.gz 4.1 GB
EGAF00006530642 fastq.gz 2.1 GB
EGAF00006530643 fastq.gz 4.0 GB
EGAF00006530644 fastq.gz 3.2 GB
EGAF00006530645 fastq.gz 7.2 GB
EGAF00006530646 fastq.gz 3.2 GB
EGAF00006530647 fastq.gz 7.3 GB
EGAF00006530648 fastq.gz 3.2 GB
EGAF00006530649 fastq.gz 7.3 GB
EGAF00006530650 fastq.gz 3.2 GB
EGAF00006530651 fastq.gz 7.2 GB
EGAF00006530652 fastq.gz 585.3 MB
EGAF00006530653 fastq.gz 1.2 GB
EGAF00006530654 fastq.gz 677.1 MB
EGAF00006530655 fastq.gz 1.4 GB
EGAF00006530656 fastq.gz 2.0 GB
EGAF00006530657 fastq.gz 4.2 GB
EGAF00006530658 fastq.gz 2.0 GB
EGAF00006530659 fastq.gz 4.2 GB
EGAF00006530660 fastq.gz 571.2 MB
EGAF00006530661 fastq.gz 1.1 GB
EGAF00006530662 fastq.gz 661.5 MB
EGAF00006530663 fastq.gz 1.2 GB
EGAF00006530664 fastq.gz 2.0 GB
EGAF00006530665 fastq.gz 3.8 GB
EGAF00006530666 fastq.gz 2.0 GB
EGAF00006530667 fastq.gz 3.8 GB
EGAF00006530668 fastq.gz 3.2 GB
EGAF00006530669 fastq.gz 6.4 GB
EGAF00006530670 fastq.gz 3.2 GB
EGAF00006530671 fastq.gz 6.4 GB
EGAF00006530672 fastq.gz 3.2 GB
EGAF00006530673 fastq.gz 6.4 GB
EGAF00006530674 fastq.gz 3.2 GB
EGAF00006530675 fastq.gz 6.4 GB
EGAF00006530676 fastq.gz 2.5 GB
EGAF00006530677 fastq.gz 5.4 GB
EGAF00006530678 fastq.gz 2.4 GB
EGAF00006530679 fastq.gz 5.2 GB
EGAF00006530680 fastq.gz 2.1 GB
EGAF00006530681 fastq.gz 4.7 GB
EGAF00006530682 fastq.gz 2.0 GB
EGAF00006530683 fastq.gz 4.6 GB
EGAF00006530684 fastq.gz 3.5 GB
EGAF00006530685 fastq.gz 6.9 GB
EGAF00006530686 fastq.gz 3.5 GB
EGAF00006530687 fastq.gz 6.8 GB
EGAF00006530688 fastq.gz 3.5 GB
EGAF00006530689 fastq.gz 6.9 GB
EGAF00006530690 fastq.gz 3.5 GB
EGAF00006530691 fastq.gz 6.8 GB
EGAF00006530692 fastq.gz 3.9 GB
EGAF00006530693 fastq.gz 8.7 GB
EGAF00006530694 fastq.gz 3.8 GB
EGAF00006530695 fastq.gz 8.6 GB
EGAF00006530696 fastq.gz 3.9 GB
EGAF00006530697 fastq.gz 8.7 GB
EGAF00006530698 fastq.gz 3.8 GB
EGAF00006530699 fastq.gz 8.5 GB
EGAF00006530700 fastq.gz 3.1 GB
EGAF00006530701 fastq.gz 6.3 GB
EGAF00006530702 fastq.gz 3.1 GB
EGAF00006530703 fastq.gz 6.3 GB
EGAF00006530704 fastq.gz 3.1 GB
EGAF00006530705 fastq.gz 6.3 GB
EGAF00006530706 fastq.gz 3.1 GB
EGAF00006530707 fastq.gz 6.2 GB
EGAF00006530708 fastq.gz 3.1 GB
EGAF00006530709 fastq.gz 6.5 GB
EGAF00006530710 fastq.gz 3.0 GB
EGAF00006530711 fastq.gz 6.5 GB
EGAF00006530712 fastq.gz 3.1 GB
EGAF00006530713 fastq.gz 6.5 GB
EGAF00006530714 fastq.gz 3.1 GB
EGAF00006530715 fastq.gz 6.5 GB
140 Files (589.5 GB)