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Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal-fetal interface upon SARS-CoV-2 infection

We assessed the transcriptome and chromatin states of patient and control samples at both bulk and single-cell resolutions with RNA-seq and ATAC-seq. Maternal-fetal interface samples were collected from 7 patients infected with SARS-CoV-2 during late pregnancy, and from 7 gestational age-matched control donors. Raw and processed files are provided in this dataset.

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EU-STANDS4PM_hDAA_v1.0.docx

In signing this Agreement: 1. You, the Data Recipient, agree to only use the Data for the Purpose of the Project. 2. You agree to preserve, at all times, the confidentiality of information and Data pertaining to Data Subjects. You undertake not to use or attempt to use the Data to compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy. 3. You agree not to attempt to identify Data Subjects. 4. You and your Authorised Personnel agree to take into consideration any usage restrictions (if any), stemming from consent, i.e. the appropriate lawful basis for processing the Data, as well as any usage restrictions stemming from any applicable internal policies of your Institution. 5. You agree that in handling this Data You will follow an up-to-date information technology (IT) policy that must include, at a minimum, the following items: a. Logging and auditing of Access to the Data and to the computer network; b. Password protection to computer network and/or strong data encryption; c. Virus and malware protection to computers on the computer network; d. Secure backup procedure; 6. You acknowledge that Access to the Data is granted for the duration of the Project described in Section I, as well as any new Project under the same research field or area. Any use of the Data for a Project of another research field or area will need to be approved under a new Agreement. 7. You recognize that nothing in this Agreement shall operate to transfer to You any intellectual property rights to the Data. 8. You agree not to make intellectual property claims on the Data and not to use intellectual property protection in ways that would prevent or block Access to, or use of, any element of the Data. 9. You can elect to perform further Research that would add intellectual and resource capital to the Data, and decide to obtain intellectual property rights on these downstream discoveries. In this case, You agree to implement licensing policies that will not obstruct further Research, following the Organisation for Economic Co-operation and Development Guidelines. 10. You agree that the Research Project 1) bears no legal responsibility for the accuracy or comprehensiveness of the Data; 2) accepts no liability for indirect, consequential, or incidental damages or losses arising from use of the Data; and 3) bears no responsibility for the further analysis or interpretation of these Data over and above that published by the Controller(s). 11. You agree to hold the Data Subject(s) and Data Controller(s) harmless and to defend and indemnify all these parties against all liabilities, demands, damages, expenses, and losses arising out of Your use for any Purpose of the Data. 12. You agree to a moratorium on publishing global analyses of the dataset until the Data Controller(s) have published their own global analysis or twelve (12) months, the maximum, have passed from the time the Data were deposited, whichever occurs first. You acknowledge that prompt publication or public disclosure of the results of the Research Project is encouraged. You also agree that by publishing Your global analyses of the Data, you will not disclose any results generated from the Data. 13. You agree to acknowledge the contribution of the Data Controller(s) in all oral and written presentations, disclosures, and Publications resulting from all analyses of the Data. 14. You agree to use the Data in Your laboratory. Any Authorised Personnel shall work under Your direct supervision. You agree to distribute a copy of these terms to the Authorised Personnel. 15. You may not transfer any information included in the Data to anyone unless specifically designated in the Research Project, or by prior specific or general written authorisation of the Data Controller(s) responsible for the generation of the original Data in each case. 16. You may not transfer the Data itself to anyone outside the Institution, unless the Controller(s) has (have) approved such transfer and its terms in writing. 17. Should You wish to share the Data with an external collaborator, the external collaborator must complete a separate Data Access Agreement. 18. You shall ensure that ‘all’ who have Access to the Data, namely You and Your Authorised Personnel, will be listed out, and are made aware and be bound by the terms of this Agreement. You remain solely and fully responsible for Your Authorised Personnel’s non-compliance with the provision of the Agreement and/or applicable laws. 19. In case of a breach of security resulting from ‘accidental’ use of Data by You and Your Authorised Personnel, which leads to disclosure of Data, then You must report this to Data Controller(s) within 72 hours maximum, and follow any relevant rule as provided by the GDPR. 20. In case of a ‘non-accidental or minor’ breach of hDAA by You You will further be required to destroy any Data held. 21. You accept that this Agreement will terminate immediately upon ‘any’ breach by You, or its termination (see Section I). 22. You endeavour to settle any dispute with the Data Controller(s) amicably. If you are unable to reach an Agreement, you will meet and negotiate in good faith in an effort to resolve the issue. If the issue has not been resolved within a reasonable period (e.g. 30 calendar days), you are both entitled to submit it for resolution by an arbitrator. 23. Further, the language of the proceedings will be ‘English’ if not otherwise agreed. The award of the arbitration will be final and binding upon the parties concerned. 24. This Agreement (and any dispute, controversy, proceedings, or claim of whatever nature arising out of it or its formation) shall be interpreted, governed by and construed in accordance with the Laws of England and Wales, and shall be subject to the exclusive jurisdiction of the English Courts.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00006166189 1652328757006 2.0 GB
EGAF00006166190 1652329201914 2.1 GB
EGAF00006166191 1652328962302 2.3 GB
EGAF00006166192 1652328962302 2.4 GB
EGAF00006166193 1652331840042 28.8 GB
EGAF00006166196 1652329140983 1.8 GB
EGAF00006166197 1652328880491 1.9 GB
EGAF00006166198 1652328902549 2.8 GB
EGAF00006166199 1652329500589 2.8 GB
EGAF00006166200 1652328880491 1.8 GB
EGAF00006166201 1652329201914 1.9 GB
EGAF00006166202 1652329323645 2.5 GB
EGAF00006166203 1652329261031 2.5 GB
EGAF00006166204 1657081825128 10.0 GB
EGAF00006166205 1652331900020 31.9 GB
EGAF00006166206 1652332020046 36.2 GB
EGAF00006166207 1652330160470 9.0 GB
EGAF00006166208 1652328880491 1.5 GB
EGAF00006166209 1652328663376 1.6 GB
EGAF00006166210 1652329080388 2.1 GB
EGAF00006166211 1652329455307 2.2 GB
EGAF00006166212 1652332380155 35.1 GB
EGAF00006166213 1652329980195 9.0 GB
EGAF00006166214 1652330400095 9.5 GB
EGAF00006166215 1652331761487 30.2 GB
EGAF00006166218 1652332380155 34.2 GB
EGAF00006166219 1652329201914 1.9 GB
EGAF00006166220 1652328880491 2.1 GB
EGAF00006166221 1652328757006 2.0 GB
EGAF00006166222 1652329500589 2.3 GB
EGAF00006166223 1652330340117 10.3 GB
EGAF00006166224 1652332020046 33.3 GB
EGAF00006166225 1652329455307 2.5 GB
EGAF00006166226 1652328962302 2.6 GB
EGAF00006166227 1652329920141 19.4 GB
EGAF00006166228 1652333940031 61.2 GB
EGAF00006166229 1652332260052 35.5 GB
EGAF00006166230 1652329201914 2.2 GB
EGAF00006166231 1652329201914 2.3 GB
EGAF00006166232 1652329455307 2.9 GB
EGAF00006166233 1652329500589 3.1 GB
EGAF00006166234 1652331761487 29.6 GB
EGAF00006166235 1652329380349 1.7 GB
EGAF00006166236 1652329201914 1.8 GB
EGAF00006166237 1652329201914 2.3 GB
EGAF00006166238 1652328902549 2.3 GB
EGAF00006166239 1652330460963 9.7 GB
EGAF00006166240 1657085421024 30.8 GB
EGAF00006166241 1652329261031 1.6 GB
EGAF00006166242 1652329080388 1.6 GB
EGAF00006166243 1652331540049 29.9 GB
EGAF00006166244 1652329380349 7.6 GB
EGAF00006166245 1652329455307 2.2 GB
EGAF00006166246 1652329380349 2.3 GB
EGAF00006166247 1652331761487 29.5 GB
EGAF00006166248 1652329380349 7.7 GB
EGAF00006166249 1652329140983 1.4 GB
EGAF00006166250 1652328663376 1.5 GB
EGAF00006166251 1652329380349 1.8 GB
EGAF00006166252 1652329140983 1.9 GB
EGAF00006166253 1652329980195 14.5 GB
EGAF00006166254 1652332440207 45.2 GB
EGAF00006166255 1652328663376 1.7 GB
EGAF00006166256 1652329080388 1.7 GB
EGAF00006166257 1652329020336 1.7 GB
EGAF00006166258 1652328757006 1.8 GB
EGAF00006166259 1652332080149 33.8 GB
EGAF00006166260 1652332560090 37.5 GB
EGAF00006166261 1652330280143 9.1 GB
EGAF00006166262 1652329080388 1.7 GB
EGAF00006166263 1652329380349 1.7 GB
EGAF00006166264 1652328880491 1.5 GB
EGAF00006166265 1652328880491 1.6 GB
EGAF00006166266 1652328757006 818.9 MB
EGAF00006166274 1652328757006 772.1 MB
EGAF00006166276 1652328663374 197.7 MB
EGAF00006166277 1652328544997 188.2 MB
EGAF00006166281 1652328544997 234.7 MB
EGAF00006166282 1652328663373 226.0 MB
EGAF00006166285 1652328663373 242.1 MB
EGAF00006166286 1652329080388 233.4 MB
EGAF00006166287 1652328663373 312.6 MB
EGAF00006166288 1652328782725 302.8 MB
EGAF00006166292 1652328663373 224.0 MB
EGAF00006166293 1652328663373 216.0 MB
EGAF00006166294 1652328544997 232.7 MB
EGAF00006166295 1652328663373 222.4 MB
EGAF00006166301 1652328663373 241.9 MB
EGAF00006166302 1652328757006 229.2 MB
EGAF00006166303 1652328663373 789.9 MB
EGAF00006166313 1652328663373 307.9 MB
EGAF00006166314 1652328663373 293.1 MB
EGAF00006166321 1652328757006 218.3 MB
EGAF00006166322 1652328663373 208.5 MB
EGAF00006166325 1652328663373 267.8 MB
EGAF00006166326 1652328663373 257.2 MB
EGAF00006166327 1652328782725 806.1 MB
EGAF00006166334 1652328757005 828.6 MB
EGAF00006166335 1652328663374 210.3 MB
EGAF00006166336 1652328544997 200.9 MB
EGAF00006166337 1652328757005 754.7 MB
EGAF00006166338 1652328663373 829.1 MB
EGAF00006166341 1652329020336 833.4 MB
EGAF00006166354 1652328663373 812.3 MB
EGAF00006166357 1652328663373 230.3 MB
EGAF00006166358 1652328544997 219.6 MB
EGAF00006166361 1652328663373 212.4 MB
EGAF00006166362 1652328663373 203.4 MB
EGAF00006166366 1652328782725 799.6 MB
109 Files (787.0 GB)