The polarity and specificity of antiviral T lymphocyte responses determine susceptibility to SARS-CoV-2 infection in cancer patients and healthy individuals
We monitored patient's anti SARS-CoV-2 immune responses using an in vitro cross presentation assay. The goal of this study was to identify immune correlates of clinical protection against SARS-CoV-2 infection. Briefly, peripheral blood mononuclear cells of patient were divided into a monocyte and lymphocyte. Monocyte were differentiated into monocyte derived dendritic (mo-DC)cells using GM-CSF and Interferon alpha. Mo-DC were then loaded with SARS-CoV-2 culture lysates , or VeroE86 lysates. SARS-CoV-2 loaded mo-DC were then used to stimulates their autologous lymphocytes and T cell cytokine secretion was monitored in the supernatant. We discriminated patients producing IL-2 and patients producing IL-5. RNA sequencing was performed for 18 patients, to identify gene profile associated with IL-2 or IL-5 production.
- 36 samples
- DAC: EGAC00001002517
- Technology: Illumina NovaSeq 6000
Data Access Policy of The polarity and specificity of antiviral T lymphocyte responses determine susceptibility to SARS-CoV-2 infection in cancer patients and healthy individuals
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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS00001005985 | Other |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Located in | |
|---|---|---|---|---|
| EGAF00005791396 | fastq.gz | 4.1 GB | ||
| EGAF00005791397 | fastq.gz | 4.2 GB | ||
| EGAF00005791398 | fastq.gz | 6.2 GB | ||
| EGAF00005791399 | fastq.gz | 6.4 GB | ||
| EGAF00005791400 | fastq.gz | 3.5 GB | ||
| EGAF00005791401 | fastq.gz | 3.5 GB | ||
| EGAF00005791402 | fastq.gz | 25.2 GB | ||
| EGAF00005791403 | fastq.gz | 26.0 GB | ||
| EGAF00005791404 | fastq.gz | 3.7 GB | ||
| EGAF00005791405 | fastq.gz | 3.7 GB | ||
| EGAF00005791406 | fastq.gz | 3.3 GB | ||
| EGAF00005791407 | fastq.gz | 3.4 GB | ||
| EGAF00005791408 | fastq.gz | 1.8 GB | ||
| EGAF00005791409 | fastq.gz | 1.9 GB | ||
| EGAF00005791410 | fastq.gz | 2.8 GB | ||
| EGAF00005791411 | fastq.gz | 3.1 GB | ||
| EGAF00005791412 | fastq.gz | 1.3 GB | ||
| EGAF00005791413 | fastq.gz | 1.3 GB | ||
| EGAF00005791414 | fastq.gz | 4.0 GB | ||
| EGAF00005791415 | fastq.gz | 4.1 GB | ||
| EGAF00005791416 | fastq.gz | 1.7 GB | ||
| EGAF00005791417 | fastq.gz | 1.7 GB | ||
| EGAF00005791418 | fastq.gz | 3.5 GB | ||
| EGAF00005791419 | fastq.gz | 3.6 GB | ||
| EGAF00005791420 | fastq.gz | 1.7 GB | ||
| EGAF00005791421 | fastq.gz | 1.7 GB | ||
| EGAF00005791422 | fastq.gz | 2.4 GB | ||
| EGAF00005791423 | fastq.gz | 2.5 GB | ||
| EGAF00005791424 | fastq.gz | 1.3 GB | ||
| EGAF00005791425 | fastq.gz | 1.3 GB | ||
| EGAF00005791426 | fastq.gz | 1.9 GB | ||
| EGAF00005791427 | fastq.gz | 2.0 GB | ||
| EGAF00005791428 | fastq.gz | 1.8 GB | ||
| EGAF00005791429 | fastq.gz | 1.9 GB | ||
| EGAF00005791430 | fastq.gz | 2.6 GB | ||
| EGAF00005791431 | fastq.gz | 2.9 GB | ||
| EGAF00005791432 | fastq.gz | 1.7 GB | ||
| EGAF00005791433 | fastq.gz | 1.7 GB | ||
| EGAF00005791434 | fastq.gz | 2.9 GB | ||
| EGAF00005791435 | fastq.gz | 3.0 GB | ||
| EGAF00005791436 | fastq.gz | 4.7 GB | ||
| EGAF00005791437 | fastq.gz | 4.7 GB | ||
| EGAF00005791438 | fastq.gz | 6.1 GB | ||
| EGAF00005791439 | fastq.gz | 6.2 GB | ||
| EGAF00005791440 | fastq.gz | 4.7 GB | ||
| EGAF00005791441 | fastq.gz | 4.9 GB | ||
| EGAF00005791442 | fastq.gz | 5.0 GB | ||
| EGAF00005791443 | fastq.gz | 5.0 GB | ||
| EGAF00005791444 | fastq.gz | 2.4 GB | ||
| EGAF00005791445 | fastq.gz | 2.6 GB | ||
| EGAF00005791446 | fastq.gz | 1.4 GB | ||
| EGAF00005791447 | fastq.gz | 1.5 GB | ||
| EGAF00005791448 | fastq.gz | 1.7 GB | ||
| EGAF00005791449 | fastq.gz | 1.7 GB | ||
| EGAF00005791450 | fastq.gz | 4.2 GB | ||
| EGAF00005791451 | fastq.gz | 4.3 GB | ||
| EGAF00005791452 | fastq.gz | 3.8 GB | ||
| EGAF00005791453 | fastq.gz | 3.9 GB | ||
| EGAF00005791454 | fastq.gz | 4.4 GB | ||
| EGAF00005791455 | fastq.gz | 4.4 GB | ||
| EGAF00005791456 | fastq.gz | 3.7 GB | ||
| EGAF00005791457 | fastq.gz | 3.8 GB | ||
| EGAF00005791458 | fastq.gz | 6.1 GB | ||
| EGAF00005791459 | fastq.gz | 6.2 GB | ||
| EGAF00005791460 | fastq.gz | 4.8 GB | ||
| EGAF00005791461 | fastq.gz | 4.9 GB | ||
| EGAF00005791466 | fastq.gz | 4.8 GB | ||
| EGAF00005791467 | fastq.gz | 4.9 GB | ||
| EGAF00005791468 | fastq.gz | 4.7 GB | ||
| EGAF00005791469 | fastq.gz | 4.8 GB | ||
| EGAF00005791470 | fastq.gz | 6.6 GB | ||
| EGAF00005791471 | fastq.gz | 6.8 GB | ||
| 72 Files (297.0 GB) | ||||