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Targeted Myeloid DNA-Panelsequencing, DKFZ

Targeted myeloid DNA-Panelsequencing from purified bone marrow blasts of 104 treatment naive AML patients from the discovery cohort. For more details, we refere to Jayavelu, Wolf, Buettner et al. Libraries were prepared from 40 ng DNA using the QIASeq Human Myeloid Neoplasms Panel (Qiagen) according to the manufacturer’s protocol. Samples were tagged with the QIAseq 96-Unique Dual Index Set A for Illumina platforms (Qiagen) to yield unique combinations of i5 and i7 barcodes for each sample. Sample fragment size distribution and concentration was estimated using the Agilent High Sensitivity DNA kit on a 2100 Bioanalyzer (Agilent). Samples were pooled in an equimolar fashion, denatured, and diluted to 1.5 pM according to Illumina’s recommendations. The diluted library was sequenced on a NextSeq 500 benchtop sequencer (Illumina) using NextSeq High Output cartridges. Demultiplexing was performed using the BaseSpace cloud platform (Illumina).

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DAP for genomic sequencing data generated as part of the "AML proteogenomic landscape" paper.

In requesting access to and retrieving data from this repository: 1. You agree to use the Data only for the advancement of medical research, according to the consent obtained from sample donors. 2. You agree not to use the data or any part thereof for the creation of products for sale or for any commercial purpose. 3. You agree to preserve, at all times, the confidentiality of information and Data pertaining to Data Subjects. In particular, You undertake not to use, or attempt to use the Data to compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy. 4. You agree not to attempt to link the data provided under this agreement to other information or archive data available for the data sets provided, even if access to that data has been formally granted to you, or it is freely available without restriction, without specific permission being sought from the relevent access committees. 5. You agree not to transfer or disclose the Data, in whole or part, or any identifiable material derived from the Data, to others, except as necessary for data/safety monitoring or programme management. Should You wish to share the Data with a collaborator outwith the same Institution, the third party must make a separate application for access to the Data. 6. You agree to use the data for the approved purpose and project described in your application; use of the data for a new purpose or project will require a new application and approval. 7. You accept that Data will be reissued from time to time, with suitable versioning. If the reissue is at the request of sample donors and/or other ethical scrutiny, You will destroy earlier versions of the Data. 9. You agree to acknowledge in any work based in whole or part on the Data, the published paper from which the Data derives, the version of the data, and the role of the authors and the relevant primary collectors and their funders. Suitable wording is provided upon request. 10. You accept that the authors, represented by the data accessing committee, the original data creators, depositors or copyright holders, or the funders of the Data or any part of the Data supplied: a) bear no legal responsibility for the accuracy or comprehensiveness of the Data; and b) accept no liability for indirect, consequential, or incidental, damages or losses arising from use of the Data, or from the unavailability of, or break in access to, the Data for whatever reason. 11. You understand and acknowledge that the Data is protected by copyright and other intellectual property rights, and that duplication, except as reasonably required to carry out Your research with the Data, or sale of all or part of the Data on any media is not permitted. 12. You recognise that nothing in this agreement shall operate to transfer to the User Institution any intellectual property rights relating to the Data. The User Institution has the right to develop intellectual property based on comparisons with their own data. 13. You accept that this agreement will terminate immediately upon any breach of this agreement by You and You will be required to destroy any Data held. 14. You accept that it may be necessary for the authors, represented by the data accessing committee, or its appointed agent to alter the terms of this agreement from time to time in order to address new concerns. In this event, the authors, represented by the data accessing committee, or its appointed agent will contact You to inform You of any changes and You agree that Your continued use of the Data shall be dependent on the parties entering into a new version of the Agreement. 15. You agree that you will submit a report to the Data Access Committee, if requested, on completion of the agreed purpose. The Data Access Committee agrees to treat the report and all information, data, results, and conclusions contained within such report as confidential information belonging to the User Institution. 16. You accept that the Data is protected by and subject to international laws, including but not limited to the “Gendiagnostikgesetzt”, the EU General Data Protection Regulation (GDPR), and that You are responsible for ensuring compliance with any such applicable law. The Consortium Data Access Committee reserves the right to request and inspect data security and management documentation to ensure the adequacy of data protection measures in countries that have no national laws comparable to that which pertain in the EU. 17. This agreement shall be construed, interpreted and governed by the laws of the Federal Republic of Germany and the European Union and shall be subject to the non-exclusive jurisdiction of the german and european courts.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001005950 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00005784904 fastq.gz 18.4 MB
EGAF00005784905 fastq.gz 20.1 MB
EGAF00005784906 fastq.gz 453.9 MB
EGAF00005784907 fastq.gz 488.5 MB
EGAF00005784908 fastq.gz 588.6 MB
EGAF00005784909 fastq.gz 646.5 MB
EGAF00005784910 fastq.gz 886.0 MB
EGAF00005784911 fastq.gz 959.3 MB
EGAF00005784912 fastq.gz 269.9 MB
EGAF00005784913 fastq.gz 290.2 MB
EGAF00005784914 fastq.gz 934.7 MB
EGAF00005784915 fastq.gz 1.0 GB
EGAF00005784916 fastq.gz 242.9 MB
EGAF00005784917 fastq.gz 267.7 MB
EGAF00005784918 fastq.gz 254.5 MB
EGAF00005784919 fastq.gz 282.0 MB
EGAF00005784920 fastq.gz 505.5 MB
EGAF00005784921 fastq.gz 556.2 MB
EGAF00005784922 fastq.gz 679.3 MB
EGAF00005784923 fastq.gz 747.6 MB
EGAF00005784924 fastq.gz 450.1 MB
EGAF00005784925 fastq.gz 484.6 MB
EGAF00005784926 fastq.gz 413.8 MB
EGAF00005784927 fastq.gz 444.7 MB
EGAF00005784928 fastq.gz 27.9 MB
EGAF00005784929 fastq.gz 30.7 MB
EGAF00005784930 fastq.gz 586.1 MB
EGAF00005784931 fastq.gz 644.0 MB
EGAF00005784932 fastq.gz 168.3 MB
EGAF00005784933 fastq.gz 182.1 MB
EGAF00005784934 fastq.gz 729.4 MB
EGAF00005784935 fastq.gz 808.3 MB
EGAF00005784936 fastq.gz 286.7 MB
EGAF00005784937 fastq.gz 311.0 MB
EGAF00005784938 fastq.gz 728.4 MB
EGAF00005784939 fastq.gz 808.7 MB
EGAF00005784940 fastq.gz 945.7 MB
EGAF00005784941 fastq.gz 1.0 GB
EGAF00005784942 fastq.gz 619.3 MB
EGAF00005784943 fastq.gz 682.0 MB
EGAF00005784944 fastq.gz 467.3 MB
EGAF00005784945 fastq.gz 513.2 MB
EGAF00005784946 fastq.gz 303.0 MB
EGAF00005784947 fastq.gz 335.6 MB
EGAF00005784948 fastq.gz 587.1 MB
EGAF00005784949 fastq.gz 632.8 MB
EGAF00005784950 fastq.gz 962.5 MB
EGAF00005784951 fastq.gz 1.1 GB
EGAF00005784952 fastq.gz 286.5 MB
EGAF00005784953 fastq.gz 310.1 MB
EGAF00005784954 fastq.gz 743.3 MB
EGAF00005784955 fastq.gz 821.4 MB
EGAF00005784956 fastq.gz 569.5 MB
EGAF00005784957 fastq.gz 628.8 MB
EGAF00005784958 fastq.gz 1.2 GB
EGAF00005784959 fastq.gz 1.3 GB
EGAF00005784960 fastq.gz 251.6 MB
EGAF00005784961 fastq.gz 277.7 MB
EGAF00005784962 fastq.gz 506.6 MB
EGAF00005784963 fastq.gz 525.3 MB
EGAF00005784964 fastq.gz 748.3 MB
EGAF00005784965 fastq.gz 822.7 MB
EGAF00005784968 fastq.gz 64.9 MB
EGAF00005784969 fastq.gz 70.9 MB
EGAF00005784970 fastq.gz 2.7 GB
EGAF00005784971 fastq.gz 2.9 GB
EGAF00005784972 fastq.gz 750.1 MB
EGAF00005784973 fastq.gz 828.4 MB
EGAF00005784974 fastq.gz 362.7 MB
EGAF00005784975 fastq.gz 399.7 MB
EGAF00005784976 fastq.gz 1.6 GB
EGAF00005784977 fastq.gz 1.8 GB
EGAF00005784978 fastq.gz 685.8 MB
EGAF00005784979 fastq.gz 712.6 MB
EGAF00005784980 fastq.gz 1.3 GB
EGAF00005784981 fastq.gz 1.4 GB
EGAF00005784982 fastq.gz 353.3 MB
EGAF00005784983 fastq.gz 380.5 MB
EGAF00005784984 fastq.gz 726.2 MB
EGAF00005784985 fastq.gz 797.6 MB
EGAF00005784986 fastq.gz 2.1 GB
EGAF00005784987 fastq.gz 2.3 GB
EGAF00005784988 fastq.gz 393.2 MB
EGAF00005784989 fastq.gz 424.8 MB
EGAF00005784990 fastq.gz 730.8 MB
EGAF00005784991 fastq.gz 801.7 MB
EGAF00005784992 fastq.gz 1.4 GB
EGAF00005784993 fastq.gz 1.4 GB
EGAF00005784994 fastq.gz 351.3 MB
EGAF00005784995 fastq.gz 378.3 MB
EGAF00005784996 fastq.gz 535.3 MB
EGAF00005784997 fastq.gz 556.8 MB
EGAF00005784998 fastq.gz 1.1 GB
EGAF00005784999 fastq.gz 1.1 GB
EGAF00005785000 fastq.gz 298.2 MB
EGAF00005785001 fastq.gz 309.5 MB
EGAF00005785002 fastq.gz 200.1 MB
EGAF00005785003 fastq.gz 216.0 MB
EGAF00005785004 fastq.gz 150.2 MB
EGAF00005785005 fastq.gz 165.6 MB
EGAF00005785006 fastq.gz 399.4 MB
EGAF00005785007 fastq.gz 440.7 MB
EGAF00005785008 fastq.gz 1.9 GB
EGAF00005785009 fastq.gz 2.0 GB
EGAF00005785010 fastq.gz 308.7 MB
EGAF00005785011 fastq.gz 320.0 MB
EGAF00005785012 fastq.gz 286.9 MB
EGAF00005785013 fastq.gz 297.4 MB
EGAF00005785014 fastq.gz 315.3 MB
EGAF00005785015 fastq.gz 347.2 MB
EGAF00005785016 fastq.gz 798.8 MB
EGAF00005785017 fastq.gz 880.6 MB
EGAF00005785018 fastq.gz 862.7 MB
EGAF00005785019 fastq.gz 895.6 MB
EGAF00005785020 fastq.gz 1.8 GB
EGAF00005785021 fastq.gz 1.8 GB
EGAF00005785022 fastq.gz 1.1 GB
EGAF00005785023 fastq.gz 1.2 GB
EGAF00005785024 fastq.gz 983.3 MB
EGAF00005785025 fastq.gz 1.1 GB
EGAF00005785026 fastq.gz 414.4 MB
EGAF00005785027 fastq.gz 429.8 MB
EGAF00005785028 fastq.gz 785.9 MB
EGAF00005785029 fastq.gz 866.6 MB
EGAF00005785030 fastq.gz 332.6 MB
EGAF00005785031 fastq.gz 362.1 MB
EGAF00005785032 fastq.gz 945.6 MB
EGAF00005785033 fastq.gz 1.0 GB
EGAF00005785034 fastq.gz 472.9 MB
EGAF00005785035 fastq.gz 492.5 MB
EGAF00005785036 fastq.gz 212.0 MB
EGAF00005785037 fastq.gz 233.0 MB
EGAF00005785038 fastq.gz 739.2 MB
EGAF00005785039 fastq.gz 812.5 MB
EGAF00005785040 fastq.gz 730.8 MB
EGAF00005785041 fastq.gz 800.7 MB
EGAF00005785042 fastq.gz 948.7 MB
EGAF00005785043 fastq.gz 1.0 GB
EGAF00005785044 fastq.gz 650.5 MB
EGAF00005785045 fastq.gz 704.8 MB
EGAF00005785046 fastq.gz 375.4 MB
EGAF00005785047 fastq.gz 413.5 MB
EGAF00005785048 fastq.gz 691.3 MB
EGAF00005785049 fastq.gz 760.0 MB
EGAF00005785050 fastq.gz 439.2 MB
EGAF00005785051 fastq.gz 462.9 MB
EGAF00005785052 fastq.gz 260.1 MB
EGAF00005785053 fastq.gz 270.1 MB
EGAF00005785054 fastq.gz 1.3 GB
EGAF00005785055 fastq.gz 1.4 GB
EGAF00005785056 fastq.gz 2.0 GB
EGAF00005785057 fastq.gz 2.2 GB
EGAF00005785058 fastq.gz 398.4 MB
EGAF00005785059 fastq.gz 429.2 MB
EGAF00005785060 fastq.gz 626.5 MB
EGAF00005785061 fastq.gz 678.1 MB
EGAF00005785062 fastq.gz 2.4 GB
EGAF00005785063 fastq.gz 2.7 GB
EGAF00005785064 fastq.gz 399.6 MB
EGAF00005785065 fastq.gz 431.0 MB
EGAF00005785066 fastq.gz 462.5 MB
EGAF00005785067 fastq.gz 479.9 MB
EGAF00005785068 fastq.gz 280.6 MB
EGAF00005785069 fastq.gz 291.0 MB
EGAF00005785070 fastq.gz 189.8 MB
EGAF00005785071 fastq.gz 204.5 MB
EGAF00005785072 fastq.gz 310.2 MB
EGAF00005785073 fastq.gz 335.0 MB
EGAF00005785074 fastq.gz 558.3 MB
EGAF00005785075 fastq.gz 616.5 MB
EGAF00005785076 fastq.gz 340.6 MB
EGAF00005785077 fastq.gz 367.1 MB
EGAF00005785078 fastq.gz 251.7 MB
EGAF00005785079 fastq.gz 276.9 MB
EGAF00005785080 fastq.gz 302.6 MB
EGAF00005785081 fastq.gz 314.5 MB
EGAF00005785082 fastq.gz 377.9 MB
EGAF00005785083 fastq.gz 417.6 MB
EGAF00005785084 fastq.gz 235.7 MB
EGAF00005785085 fastq.gz 254.7 MB
EGAF00005785086 fastq.gz 257.1 MB
EGAF00005785087 fastq.gz 289.2 MB
EGAF00005785088 fastq.gz 322.1 MB
EGAF00005785089 fastq.gz 349.4 MB
EGAF00005785090 fastq.gz 706.4 MB
EGAF00005785091 fastq.gz 779.2 MB
EGAF00005785092 fastq.gz 264.5 MB
EGAF00005785093 fastq.gz 274.5 MB
EGAF00005785094 fastq.gz 221.6 MB
EGAF00005785095 fastq.gz 245.0 MB
EGAF00005785096 fastq.gz 348.4 MB
EGAF00005785097 fastq.gz 382.3 MB
EGAF00005785098 fastq.gz 511.0 MB
EGAF00005785099 fastq.gz 562.7 MB
EGAF00005785100 fastq.gz 403.4 MB
EGAF00005785101 fastq.gz 441.2 MB
EGAF00005785102 fastq.gz 950.7 MB
EGAF00005785103 fastq.gz 1.0 GB
EGAF00005785104 fastq.gz 338.2 MB
EGAF00005785105 fastq.gz 351.8 MB
EGAF00005785106 fastq.gz 719.6 MB
EGAF00005785107 fastq.gz 794.0 MB
EGAF00005785108 fastq.gz 949.5 MB
EGAF00005785109 fastq.gz 1.0 GB
EGAF00005785110 fastq.gz 176.7 MB
EGAF00005785111 fastq.gz 193.9 MB
EGAF00005785112 xlsx 1.7 MB
EGAF00007020925 fastq.gz 942.9 MB
208 Files (137.4 GB)