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Targeted Myeloid DNA-Panelsequencing, MLL

Sequencing data from a targeted myeloid DNA-Panelsequnencing at the MLL Dx, Munich lab. Targeted sequencing was performed using the Nextera DNA Flex library preparation kit, starting with 100ng of genomic DNA (Illumina, San Diego, CA, USA). The target regions were enriched by a custom xGen Lockdown panel using a hybridization capture workflow (IDT Integrated DNA Technologies, Coralville, IA, USA). All libraries were sequenced with 100bp paired-end reads on a NovaSeq6000 (Illumina) with a mean coverage of 3206x. Somatic variant calling was performed with Pisces and a sensitivity cut off of 2%. Large deletions and medium-sized insertions, as they are for example found in CALR and FLT3, were called with Pindel. Variant annotation considered the publicly available data bases Cosmic (v91), ClinVar (2020-03), gnomAd (non-cancer, v2.1.1), dbNSFP (v3.5) and UMD TP53 (2017_R2). Variants that are described as somatic, protein truncating or affecting splice sites were considered as mutations while variants with no or discrepant data base information were considered as variant of uncertain significance.

Request Access

DAP for genomic sequencing data generated as part of the "AML proteogenomic landscape" paper.

In requesting access to and retrieving data from this repository: 1. You agree to use the Data only for the advancement of medical research, according to the consent obtained from sample donors. 2. You agree not to use the data or any part thereof for the creation of products for sale or for any commercial purpose. 3. You agree to preserve, at all times, the confidentiality of information and Data pertaining to Data Subjects. In particular, You undertake not to use, or attempt to use the Data to compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy. 4. You agree not to attempt to link the data provided under this agreement to other information or archive data available for the data sets provided, even if access to that data has been formally granted to you, or it is freely available without restriction, without specific permission being sought from the relevent access committees. 5. You agree not to transfer or disclose the Data, in whole or part, or any identifiable material derived from the Data, to others, except as necessary for data/safety monitoring or programme management. Should You wish to share the Data with a collaborator outwith the same Institution, the third party must make a separate application for access to the Data. 6. You agree to use the data for the approved purpose and project described in your application; use of the data for a new purpose or project will require a new application and approval. 7. You accept that Data will be reissued from time to time, with suitable versioning. If the reissue is at the request of sample donors and/or other ethical scrutiny, You will destroy earlier versions of the Data. 9. You agree to acknowledge in any work based in whole or part on the Data, the published paper from which the Data derives, the version of the data, and the role of the authors and the relevant primary collectors and their funders. Suitable wording is provided upon request. 10. You accept that the authors, represented by the data accessing committee, the original data creators, depositors or copyright holders, or the funders of the Data or any part of the Data supplied: a) bear no legal responsibility for the accuracy or comprehensiveness of the Data; and b) accept no liability for indirect, consequential, or incidental, damages or losses arising from use of the Data, or from the unavailability of, or break in access to, the Data for whatever reason. 11. You understand and acknowledge that the Data is protected by copyright and other intellectual property rights, and that duplication, except as reasonably required to carry out Your research with the Data, or sale of all or part of the Data on any media is not permitted. 12. You recognise that nothing in this agreement shall operate to transfer to the User Institution any intellectual property rights relating to the Data. The User Institution has the right to develop intellectual property based on comparisons with their own data. 13. You accept that this agreement will terminate immediately upon any breach of this agreement by You and You will be required to destroy any Data held. 14. You accept that it may be necessary for the authors, represented by the data accessing committee, or its appointed agent to alter the terms of this agreement from time to time in order to address new concerns. In this event, the authors, represented by the data accessing committee, or its appointed agent will contact You to inform You of any changes and You agree that Your continued use of the Data shall be dependent on the parties entering into a new version of the Agreement. 15. You agree that you will submit a report to the Data Access Committee, if requested, on completion of the agreed purpose. The Data Access Committee agrees to treat the report and all information, data, results, and conclusions contained within such report as confidential information belonging to the User Institution. 16. You accept that the Data is protected by and subject to international laws, including but not limited to the “Gendiagnostikgesetzt”, the EU General Data Protection Regulation (GDPR), and that You are responsible for ensuring compliance with any such applicable law. The Consortium Data Access Committee reserves the right to request and inspect data security and management documentation to ensure the adequacy of data protection measures in countries that have no national laws comparable to that which pertain in the EU. 17. This agreement shall be construed, interpreted and governed by the laws of the Federal Republic of Germany and the European Union and shall be subject to the non-exclusive jurisdiction of the german and european courts.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001005950 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00005777111 fastq.gz 361.1 MB
EGAF00005777112 fastq.gz 380.8 MB
EGAF00005777113 fastq.gz 287.0 MB
EGAF00005777114 fastq.gz 307.5 MB
EGAF00005777115 fastq.gz 299.5 MB
EGAF00005777116 fastq.gz 313.6 MB
EGAF00005777117 fastq.gz 272.5 MB
EGAF00005777118 fastq.gz 283.5 MB
EGAF00005777119 fastq.gz 569.1 MB
EGAF00005777120 fastq.gz 604.4 MB
EGAF00005777121 fastq.gz 776.2 MB
EGAF00005777122 fastq.gz 816.4 MB
EGAF00005777123 fastq.gz 323.4 MB
EGAF00005777124 fastq.gz 342.1 MB
EGAF00005777125 fastq.gz 619.6 MB
EGAF00005777126 fastq.gz 610.3 MB
EGAF00005777127 fastq.gz 579.8 MB
EGAF00005777128 fastq.gz 606.6 MB
EGAF00005777129 fastq.gz 287.3 MB
EGAF00005777130 fastq.gz 301.0 MB
EGAF00005777131 fastq.gz 302.5 MB
EGAF00005777132 fastq.gz 318.9 MB
EGAF00005777133 fastq.gz 457.5 MB
EGAF00005777134 fastq.gz 488.8 MB
EGAF00005777135 fastq.gz 346.1 MB
EGAF00005777136 fastq.gz 367.1 MB
EGAF00005777137 fastq.gz 895.3 MB
EGAF00005777138 fastq.gz 959.2 MB
EGAF00005777139 fastq.gz 349.4 MB
EGAF00005777140 fastq.gz 369.0 MB
EGAF00005777141 fastq.gz 323.3 MB
EGAF00005777142 fastq.gz 341.5 MB
EGAF00005777143 fastq.gz 335.2 MB
EGAF00005777144 fastq.gz 353.3 MB
EGAF00005777145 fastq.gz 388.9 MB
EGAF00005777146 fastq.gz 407.0 MB
EGAF00005777147 fastq.gz 322.3 MB
EGAF00005777148 fastq.gz 337.7 MB
EGAF00005777149 fastq.gz 299.1 MB
EGAF00005777150 fastq.gz 310.1 MB
EGAF00005777151 fastq.gz 692.6 MB
EGAF00005777152 fastq.gz 567.2 MB
EGAF00005777153 fastq.gz 332.9 MB
EGAF00005777154 fastq.gz 348.0 MB
EGAF00005777155 fastq.gz 289.1 MB
EGAF00005777156 fastq.gz 308.4 MB
EGAF00005777157 fastq.gz 295.4 MB
EGAF00005777158 fastq.gz 306.7 MB
EGAF00005777159 fastq.gz 335.3 MB
EGAF00005777160 fastq.gz 348.7 MB
EGAF00005777161 fastq.gz 333.1 MB
EGAF00005777162 fastq.gz 354.5 MB
EGAF00005777163 fastq.gz 285.6 MB
EGAF00005777164 fastq.gz 307.2 MB
EGAF00005777165 fastq.gz 304.8 MB
EGAF00005777166 fastq.gz 320.0 MB
EGAF00005777167 fastq.gz 682.6 MB
EGAF00005777168 fastq.gz 697.5 MB
EGAF00005777169 fastq.gz 633.7 MB
EGAF00005777170 fastq.gz 621.8 MB
EGAF00005777171 fastq.gz 271.4 MB
EGAF00005777172 fastq.gz 285.0 MB
EGAF00005777173 fastq.gz 324.0 MB
EGAF00005777174 fastq.gz 338.1 MB
EGAF00005777175 fastq.gz 345.7 MB
EGAF00005777176 fastq.gz 361.4 MB
EGAF00005777177 fastq.gz 365.1 MB
EGAF00005777178 fastq.gz 387.5 MB
EGAF00005777179 fastq.gz 325.5 MB
EGAF00005777180 fastq.gz 339.8 MB
EGAF00005777181 fastq.gz 433.9 MB
EGAF00005777182 fastq.gz 453.2 MB
EGAF00005777183 fastq.gz 367.5 MB
EGAF00005777184 fastq.gz 388.5 MB
EGAF00005777185 fastq.gz 338.2 MB
EGAF00005777186 fastq.gz 355.0 MB
EGAF00005777187 fastq.gz 725.5 MB
EGAF00005777188 fastq.gz 789.1 MB
EGAF00005777189 fastq.gz 329.1 MB
EGAF00005777190 fastq.gz 347.2 MB
EGAF00005777191 fastq.gz 291.2 MB
EGAF00005777192 fastq.gz 281.2 MB
EGAF00005777193 fastq.gz 320.8 MB
EGAF00005777194 fastq.gz 337.1 MB
EGAF00005777195 fastq.gz 324.9 MB
EGAF00005777196 fastq.gz 350.7 MB
EGAF00005777197 fastq.gz 681.4 MB
EGAF00005777198 fastq.gz 624.5 MB
EGAF00005777199 fastq.gz 392.0 MB
EGAF00005777200 fastq.gz 408.7 MB
EGAF00005777201 fastq.gz 291.9 MB
EGAF00005777202 fastq.gz 303.0 MB
EGAF00005777203 fastq.gz 325.0 MB
EGAF00005777204 fastq.gz 343.8 MB
EGAF00005777205 fastq.gz 367.7 MB
EGAF00005777206 fastq.gz 387.9 MB
EGAF00005777207 fastq.gz 325.0 MB
EGAF00005777208 fastq.gz 339.7 MB
EGAF00005777209 fastq.gz 312.6 MB
EGAF00005777210 fastq.gz 330.5 MB
EGAF00005777211 fastq.gz 299.0 MB
EGAF00005777212 fastq.gz 313.4 MB
EGAF00005777213 fastq.gz 290.1 MB
EGAF00005777214 fastq.gz 302.4 MB
EGAF00005777215 fastq.gz 342.2 MB
EGAF00005777216 fastq.gz 357.5 MB
EGAF00005777217 fastq.gz 365.1 MB
EGAF00005777218 fastq.gz 379.1 MB
EGAF00005777219 fastq.gz 333.1 MB
EGAF00005777220 fastq.gz 347.9 MB
EGAF00005777221 fastq.gz 762.3 MB
EGAF00005777222 fastq.gz 771.0 MB
EGAF00005777223 fastq.gz 700.2 MB
EGAF00005777224 fastq.gz 713.2 MB
EGAF00005777225 fastq.gz 301.1 MB
EGAF00005777226 fastq.gz 311.0 MB
EGAF00005777227 fastq.gz 782.4 MB
EGAF00005777228 fastq.gz 824.8 MB
EGAF00005777229 fastq.gz 339.3 MB
EGAF00005777230 fastq.gz 356.1 MB
EGAF00005777231 fastq.gz 761.8 MB
EGAF00005777232 fastq.gz 802.1 MB
EGAF00005777233 fastq.gz 580.4 MB
EGAF00005777234 fastq.gz 616.6 MB
EGAF00005777235 fastq.gz 270.7 MB
EGAF00005777236 fastq.gz 282.7 MB
EGAF00005777237 fastq.gz 323.1 MB
EGAF00005777238 fastq.gz 338.1 MB
EGAF00005777239 fastq.gz 755.8 MB
EGAF00005777240 fastq.gz 798.6 MB
EGAF00005777241 fastq.gz 575.4 MB
EGAF00005777242 fastq.gz 604.6 MB
EGAF00005777243 fastq.gz 310.3 MB
EGAF00005777244 fastq.gz 329.2 MB
EGAF00005777245 fastq.gz 334.8 MB
EGAF00005777246 fastq.gz 354.8 MB
EGAF00005777247 fastq.gz 783.7 MB
EGAF00005777248 fastq.gz 820.4 MB
EGAF00005777249 fastq.gz 635.3 MB
EGAF00005777250 fastq.gz 669.8 MB
EGAF00005777251 fastq.gz 300.2 MB
EGAF00005777252 fastq.gz 335.4 MB
EGAF00005777253 fastq.gz 326.6 MB
EGAF00005777254 fastq.gz 346.1 MB
EGAF00005777255 fastq.gz 607.2 MB
EGAF00005777256 fastq.gz 651.4 MB
EGAF00005777257 fastq.gz 324.5 MB
EGAF00005777258 fastq.gz 337.5 MB
EGAF00005777259 fastq.gz 372.5 MB
EGAF00005777260 fastq.gz 390.8 MB
EGAF00005777261 fastq.gz 323.0 MB
EGAF00005777262 fastq.gz 338.7 MB
EGAF00005777263 fastq.gz 333.9 MB
EGAF00005777264 fastq.gz 350.7 MB
EGAF00005777265 fastq.gz 300.6 MB
EGAF00005777266 fastq.gz 318.9 MB
EGAF00005777267 fastq.gz 292.2 MB
EGAF00005777268 fastq.gz 300.7 MB
EGAF00005777269 fastq.gz 330.6 MB
EGAF00005777270 fastq.gz 346.9 MB
EGAF00005777271 fastq.gz 375.4 MB
EGAF00005777272 fastq.gz 394.7 MB
EGAF00005777273 fastq.gz 303.0 MB
EGAF00005777274 fastq.gz 320.1 MB
EGAF00005777275 fastq.gz 378.3 MB
EGAF00005777276 fastq.gz 396.1 MB
EGAF00005777277 fastq.gz 293.7 MB
EGAF00005777278 fastq.gz 300.9 MB
EGAF00005777279 fastq.gz 461.0 MB
EGAF00005777280 fastq.gz 490.7 MB
EGAF00005777281 fastq.gz 327.2 MB
EGAF00005777282 fastq.gz 344.6 MB
EGAF00005777283 fastq.gz 759.2 MB
EGAF00005777284 fastq.gz 797.0 MB
EGAF00005777285 fastq.gz 320.9 MB
EGAF00005777286 fastq.gz 340.9 MB
EGAF00005777287 fastq.gz 315.1 MB
EGAF00005777288 fastq.gz 330.8 MB
EGAF00005777289 fastq.gz 889.0 MB
EGAF00005777290 fastq.gz 955.4 MB
EGAF00005777291 fastq.gz 612.3 MB
EGAF00005777292 fastq.gz 654.0 MB
EGAF00005777293 fastq.gz 605.7 MB
EGAF00005777294 fastq.gz 633.8 MB
EGAF00005777295 fastq.gz 330.8 MB
EGAF00005777296 fastq.gz 347.8 MB
EGAF00005777297 fastq.gz 284.9 MB
EGAF00005777298 fastq.gz 300.3 MB
EGAF00005777299 fastq.gz 730.5 MB
EGAF00005777300 fastq.gz 791.7 MB
EGAF00005777301 fastq.gz 630.3 MB
EGAF00005777302 fastq.gz 667.0 MB
EGAF00005777303 fastq.gz 370.9 MB
EGAF00005777304 fastq.gz 389.7 MB
EGAF00005777305 fastq.gz 287.3 MB
EGAF00005777306 fastq.gz 307.7 MB
EGAF00005777307 fastq.gz 273.3 MB
EGAF00005777308 fastq.gz 285.7 MB
EGAF00005777309 fastq.gz 293.4 MB
EGAF00005777310 fastq.gz 305.9 MB
EGAF00005777311 fastq.gz 322.6 MB
EGAF00005777312 fastq.gz 349.8 MB
EGAF00005777313 fastq.gz 336.2 MB
EGAF00005777314 fastq.gz 351.8 MB
EGAF00005777315 fastq.gz 336.8 MB
EGAF00005777316 fastq.gz 350.2 MB
EGAF00005777317 fastq.gz 382.6 MB
EGAF00005777318 fastq.gz 401.1 MB
EGAF00005777319 fastq.gz 298.1 MB
EGAF00005777320 fastq.gz 334.6 MB
EGAF00005777321 fastq.gz 285.8 MB
EGAF00005777322 fastq.gz 300.7 MB
EGAF00005777323 fastq.gz 343.1 MB
EGAF00005777324 fastq.gz 360.2 MB
EGAF00005777325 fastq.gz 333.6 MB
EGAF00005777326 fastq.gz 349.1 MB
EGAF00005777327 fastq.gz 569.5 MB
EGAF00005777328 fastq.gz 596.1 MB
EGAF00005777329 fastq.gz 310.5 MB
EGAF00005777330 fastq.gz 330.1 MB
EGAF00005777331 fastq.gz 308.2 MB
EGAF00005777332 fastq.gz 328.9 MB
EGAF00005777333 fastq.gz 286.7 MB
EGAF00005777334 fastq.gz 301.0 MB
EGAF00005777335 fastq.gz 437.9 MB
EGAF00005777336 fastq.gz 455.4 MB
EGAF00005777337 fastq.gz 301.7 MB
EGAF00005777338 fastq.gz 314.5 MB
EGAF00005777339 fastq.gz 322.8 MB
EGAF00005777340 fastq.gz 339.0 MB
EGAF00005777341 fastq.gz 602.4 MB
EGAF00005777342 fastq.gz 633.2 MB
EGAF00005777343 fastq.gz 253.3 MB
EGAF00005777344 fastq.gz 266.3 MB
EGAF00005777345 fastq.gz 375.0 MB
EGAF00005777346 fastq.gz 391.6 MB
EGAF00005777347 fastq.gz 583.4 MB
EGAF00005777348 fastq.gz 610.0 MB
EGAF00005777349 fastq.gz 363.7 MB
EGAF00005777350 fastq.gz 381.9 MB
EGAF00005777351 fastq.gz 325.8 MB
EGAF00005777352 fastq.gz 342.6 MB
EGAF00005777353 fastq.gz 304.6 MB
EGAF00005777354 fastq.gz 324.0 MB
EGAF00005777355 fastq.gz 811.2 MB
EGAF00005777356 fastq.gz 851.4 MB
EGAF00005777357 fastq.gz 362.4 MB
EGAF00005777358 fastq.gz 377.9 MB
EGAF00005777359 fastq.gz 803.2 MB
EGAF00005777360 fastq.gz 846.0 MB
EGAF00005777361 fastq.gz 251.8 MB
EGAF00005777362 fastq.gz 303.4 MB
EGAF00005777363 fastq.gz 380.1 MB
EGAF00005777364 fastq.gz 778.3 MB
EGAF00005777365 fastq.gz 349.2 MB
EGAF00005777366 fastq.gz 326.3 MB
EGAF00005777367 fastq.gz 296.9 MB
EGAF00005777368 fastq.gz 317.1 MB
EGAF00005779668 xlsx 464.3 kB
259 Files (109.8 GB)