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Targeted Myeloid DNA-Panelsequencing, MLL

Sequencing data from a targeted myeloid DNA-Panelsequnencing at the MLL Dx, Munich lab. Targeted sequencing was performed using the Nextera DNA Flex library preparation kit, starting with 100ng of genomic DNA (Illumina, San Diego, CA, USA). The target regions were enriched by a custom xGen Lockdown panel using a hybridization capture workflow (IDT Integrated DNA Technologies, Coralville, IA, USA). All libraries were sequenced with 100bp paired-end reads on a NovaSeq6000 (Illumina) with a mean coverage of 3206x. Somatic variant calling was performed with Pisces and a sensitivity cut off of 2%. Large deletions and medium-sized insertions, as they are for example found in CALR and FLT3, were called with Pindel. Variant annotation considered the publicly available data bases Cosmic (v91), ClinVar (2020-03), gnomAd (non-cancer, v2.1.1), dbNSFP (v3.5) and UMD TP53 (2017_R2). Variants that are described as somatic, protein truncating or affecting splice sites were considered as mutations while variants with no or discrepant data base information were considered as variant of uncertain significance.

Request Access

DAP for genomic sequencing data generated as part of the "AML proteogenomic landscape" paper.

In requesting access to and retrieving data from this repository: 1. You agree to use the Data only for the advancement of medical research, according to the consent obtained from sample donors. 2. You agree not to use the data or any part thereof for the creation of products for sale or for any commercial purpose. 3. You agree to preserve, at all times, the confidentiality of information and Data pertaining to Data Subjects. In particular, You undertake not to use, or attempt to use the Data to compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy. 4. You agree not to attempt to link the data provided under this agreement to other information or archive data available for the data sets provided, even if access to that data has been formally granted to you, or it is freely available without restriction, without specific permission being sought from the relevent access committees. 5. You agree not to transfer or disclose the Data, in whole or part, or any identifiable material derived from the Data, to others, except as necessary for data/safety monitoring or programme management. Should You wish to share the Data with a collaborator outwith the same Institution, the third party must make a separate application for access to the Data. 6. You agree to use the data for the approved purpose and project described in your application; use of the data for a new purpose or project will require a new application and approval. 7. You accept that Data will be reissued from time to time, with suitable versioning. If the reissue is at the request of sample donors and/or other ethical scrutiny, You will destroy earlier versions of the Data. 9. You agree to acknowledge in any work based in whole or part on the Data, the published paper from which the Data derives, the version of the data, and the role of the authors and the relevant primary collectors and their funders. Suitable wording is provided upon request. 10. You accept that the authors, represented by the data accessing committee, the original data creators, depositors or copyright holders, or the funders of the Data or any part of the Data supplied: a) bear no legal responsibility for the accuracy or comprehensiveness of the Data; and b) accept no liability for indirect, consequential, or incidental, damages or losses arising from use of the Data, or from the unavailability of, or break in access to, the Data for whatever reason. 11. You understand and acknowledge that the Data is protected by copyright and other intellectual property rights, and that duplication, except as reasonably required to carry out Your research with the Data, or sale of all or part of the Data on any media is not permitted. 12. You recognise that nothing in this agreement shall operate to transfer to the User Institution any intellectual property rights relating to the Data. The User Institution has the right to develop intellectual property based on comparisons with their own data. 13. You accept that this agreement will terminate immediately upon any breach of this agreement by You and You will be required to destroy any Data held. 14. You accept that it may be necessary for the authors, represented by the data accessing committee, or its appointed agent to alter the terms of this agreement from time to time in order to address new concerns. In this event, the authors, represented by the data accessing committee, or its appointed agent will contact You to inform You of any changes and You agree that Your continued use of the Data shall be dependent on the parties entering into a new version of the Agreement. 15. You agree that you will submit a report to the Data Access Committee, if requested, on completion of the agreed purpose. The Data Access Committee agrees to treat the report and all information, data, results, and conclusions contained within such report as confidential information belonging to the User Institution. 16. You accept that the Data is protected by and subject to international laws, including but not limited to the “Gendiagnostikgesetzt”, the EU General Data Protection Regulation (GDPR), and that You are responsible for ensuring compliance with any such applicable law. The Consortium Data Access Committee reserves the right to request and inspect data security and management documentation to ensure the adequacy of data protection measures in countries that have no national laws comparable to that which pertain in the EU. 17. This agreement shall be construed, interpreted and governed by the laws of the Federal Republic of Germany and the European Union and shall be subject to the non-exclusive jurisdiction of the german and european courts.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00005777111 1642673761444 361.1 MB
EGAF00005777112 1642695274660 380.8 MB
EGAF00005777113 1642680720505 287.0 MB
EGAF00005777114 1642695274660 307.5 MB
EGAF00005777115 1642673641353 299.5 MB
EGAF00005777116 1642695274660 313.6 MB
EGAF00005777117 1642695064796 272.5 MB
EGAF00005777118 1642673701630 283.5 MB
EGAF00005777119 1642695140273 569.1 MB
EGAF00005777120 1642674360299 604.4 MB
EGAF00005777121 1642680900993 776.2 MB
EGAF00005777122 1642674122171 816.4 MB
EGAF00005777123 1642680720505 323.4 MB
EGAF00005777124 1642695311169 342.1 MB
EGAF00005777125 1642674360299 619.6 MB
EGAF00005777126 1642673945773 610.3 MB
EGAF00005777127 1642673701630 579.8 MB
EGAF00005777128 1642674001038 606.6 MB
EGAF00005777129 1642696021215 287.3 MB
EGAF00005777130 1642673761444 301.0 MB
EGAF00005777131 1642695274660 302.5 MB
EGAF00005777132 1642673761444 318.9 MB
EGAF00005777133 1642696142172 457.5 MB
EGAF00005777134 1642674541931 488.8 MB
EGAF00005777135 1642695274659 346.1 MB
EGAF00005777136 1642680840503 367.1 MB
EGAF00005777137 1642709825164 895.3 MB
EGAF00005777138 1642695274659 959.2 MB
EGAF00005777139 1642695274660 349.4 MB
EGAF00005777140 1642673825515 369.0 MB
EGAF00005777141 1642673701630 323.3 MB
EGAF00005777142 1642695274660 341.5 MB
EGAF00005777143 1642695140273 335.2 MB
EGAF00005777144 1642674122171 353.3 MB
EGAF00005777145 1642695274659 388.9 MB
EGAF00005777146 1642673761444 407.0 MB
EGAF00005777147 1642673641353 322.3 MB
EGAF00005777148 1642673761444 337.7 MB
EGAF00005777149 1642695274659 299.1 MB
EGAF00005777150 1642695064796 310.1 MB
EGAF00005777151 1642674001038 692.6 MB
EGAF00005777152 1642695274659 567.2 MB
EGAF00005777153 1642673701630 332.9 MB
EGAF00005777154 1642673945773 348.0 MB
EGAF00005777155 1642673701630 289.1 MB
EGAF00005777156 1642673761444 308.4 MB
EGAF00005777157 1642695140273 295.4 MB
EGAF00005777158 1642673945773 306.7 MB
EGAF00005777159 1642695140273 335.3 MB
EGAF00005777160 1642673945773 348.7 MB
EGAF00005777161 1642674063898 333.1 MB
EGAF00005777162 1642673880955 354.5 MB
EGAF00005777163 1642709486968 285.6 MB
EGAF00005777164 1642695524056 307.2 MB
EGAF00005777165 1642695140273 304.8 MB
EGAF00005777166 1642673825515 320.0 MB
EGAF00005777167 1642680780250 682.6 MB
EGAF00005777168 1642695427094 697.5 MB
EGAF00005777169 1642709486968 633.7 MB
EGAF00005777170 1642674063898 621.8 MB
EGAF00005777171 1642673701630 271.4 MB
EGAF00005777172 1642680840503 285.0 MB
EGAF00005777173 1642680840503 324.0 MB
EGAF00005777174 1642680960331 338.1 MB
EGAF00005777175 1642695524056 345.7 MB
EGAF00005777176 1642674183366 361.4 MB
EGAF00005777177 1642695720430 365.1 MB
EGAF00005777178 1642680720505 387.5 MB
EGAF00005777179 1642695720430 325.5 MB
EGAF00005777180 1642673825515 339.8 MB
EGAF00005777181 1642695274659 433.9 MB
EGAF00005777182 1642673825515 453.2 MB
EGAF00005777183 1642674001038 367.5 MB
EGAF00005777184 1642673880955 388.5 MB
EGAF00005777185 1642673761444 338.2 MB
EGAF00005777186 1642695064796 355.0 MB
EGAF00005777187 1642674122171 725.5 MB
EGAF00005777188 1642695427094 789.1 MB
EGAF00005777189 1642695274660 329.1 MB
EGAF00005777190 1642709523686 347.2 MB
EGAF00005777191 1642674480106 291.2 MB
EGAF00005777192 1642695427094 281.2 MB
EGAF00005777193 1642695524056 320.8 MB
EGAF00005777194 1642673825515 337.1 MB
EGAF00005777195 1642673880954 324.9 MB
EGAF00005777196 1642695311169 350.7 MB
EGAF00005777197 1642695140273 681.4 MB
EGAF00005777198 1642695274660 624.5 MB
EGAF00005777199 1642673825515 392.0 MB
EGAF00005777200 1642674063898 408.7 MB
EGAF00005777201 1642695140271 291.9 MB
EGAF00005777202 1642674001038 303.0 MB
EGAF00005777203 1642674183366 325.0 MB
EGAF00005777204 1642695140273 343.8 MB
EGAF00005777205 1642709523686 367.7 MB
EGAF00005777206 1642680900993 387.9 MB
EGAF00005777207 1642695140273 325.0 MB
EGAF00005777208 1642674480106 339.7 MB
EGAF00005777209 1642680960331 312.6 MB
EGAF00005777210 1642695140273 330.5 MB
EGAF00005777211 1642695274660 299.0 MB
EGAF00005777212 1642695274660 313.4 MB
EGAF00005777213 1642695064796 290.1 MB
EGAF00005777214 1642674001038 302.4 MB
EGAF00005777215 1642695311169 342.2 MB
EGAF00005777216 1642695274660 357.5 MB
EGAF00005777217 1642673880955 365.1 MB
EGAF00005777218 1642674183366 379.1 MB
EGAF00005777219 1642695140271 333.1 MB
EGAF00005777220 1642695274659 347.9 MB
EGAF00005777221 1642695427094 762.3 MB
EGAF00005777222 1642695524056 771.0 MB
EGAF00005777223 1642681080626 700.2 MB
EGAF00005777224 1642681142117 713.2 MB
EGAF00005777225 1642674421262 301.1 MB
EGAF00005777226 1642695274659 311.0 MB
EGAF00005777227 1642673880955 782.4 MB
EGAF00005777228 1642695604119 824.8 MB
EGAF00005777229 1642695140271 339.3 MB
EGAF00005777230 1642695140271 356.1 MB
EGAF00005777231 1642695311169 761.8 MB
EGAF00005777232 1642674541931 802.1 MB
EGAF00005777233 1642681380899 580.4 MB
EGAF00005777234 1642673880955 616.6 MB
EGAF00005777235 1642695274659 270.7 MB
EGAF00005777236 1642695274659 282.7 MB
EGAF00005777237 1642673583404 323.1 MB
EGAF00005777238 1642673641353 338.1 MB
EGAF00005777239 1642673825515 755.8 MB
EGAF00005777240 1642673825515 798.6 MB
EGAF00005777241 1642673945773 575.4 MB
EGAF00005777242 1642695274659 604.6 MB
EGAF00005777243 1642695064796 310.3 MB
EGAF00005777244 1642673825515 329.2 MB
EGAF00005777245 1642673880954 334.8 MB
EGAF00005777246 1642673945773 354.8 MB
EGAF00005777247 1642673825515 783.7 MB
EGAF00005777248 1642673761444 820.4 MB
EGAF00005777249 1642674001038 635.3 MB
EGAF00005777250 1642695427094 669.8 MB
EGAF00005777251 1642673880955 300.2 MB
EGAF00005777252 1642695140271 335.4 MB
EGAF00005777253 1642673761444 326.6 MB
EGAF00005777254 1642695274659 346.1 MB
EGAF00005777255 1642673701630 607.2 MB
EGAF00005777256 1642673825515 651.4 MB
EGAF00005777257 1642673880955 324.5 MB
EGAF00005777258 1642673761444 337.5 MB
EGAF00005777259 1642695274659 372.5 MB
EGAF00005777260 1642673641353 390.8 MB
EGAF00005777261 1642673583405 323.0 MB
EGAF00005777262 1642673641353 338.7 MB
EGAF00005777263 1642673761444 333.9 MB
EGAF00005777264 1642695274659 350.7 MB
EGAF00005777265 1642673583404 300.6 MB
EGAF00005777266 1642673761444 318.9 MB
EGAF00005777267 1642673701630 292.2 MB
EGAF00005777268 1642673520335 300.7 MB
EGAF00005777269 1642695140271 330.6 MB
EGAF00005777270 1642673701630 346.9 MB
EGAF00005777271 1642673641353 375.4 MB
EGAF00005777272 1642673825514 394.7 MB
EGAF00005777273 1642673520335 303.0 MB
EGAF00005777274 1642695311169 320.1 MB
EGAF00005777275 1642673825515 378.3 MB
EGAF00005777276 1642673761444 396.1 MB
EGAF00005777277 1642673583404 293.7 MB
EGAF00005777278 1642673701630 300.9 MB
EGAF00005777279 1642674063898 461.0 MB
EGAF00005777280 1642695311168 490.7 MB
EGAF00005777281 1642673761444 327.2 MB
EGAF00005777282 1642695274659 344.6 MB
EGAF00005777283 1642673945773 759.2 MB
EGAF00005777284 1642673583404 797.0 MB
EGAF00005777285 1642709486968 320.9 MB
EGAF00005777286 1642695274659 340.9 MB
EGAF00005777287 1642673641353 315.1 MB
EGAF00005777288 1642673945773 330.8 MB
EGAF00005777289 1642673761444 889.0 MB
EGAF00005777290 1642673825515 955.4 MB
EGAF00005777291 1642673825515 612.3 MB
EGAF00005777292 1642709619981 654.0 MB
EGAF00005777293 1642673641353 605.7 MB
EGAF00005777294 1642695311169 633.8 MB
EGAF00005777295 1642673520335 330.8 MB
EGAF00005777296 1642673520335 347.8 MB
EGAF00005777297 1642696021215 284.9 MB
EGAF00005777298 1642709486968 300.3 MB
EGAF00005777299 1642695274659 730.5 MB
EGAF00005777300 1642674001038 791.7 MB
EGAF00005777301 1642695604119 630.3 MB
EGAF00005777302 1642673945773 667.0 MB
EGAF00005777303 1642673761444 370.9 MB
EGAF00005777304 1642695311169 389.7 MB
EGAF00005777305 1642695140271 287.3 MB
EGAF00005777306 1642673880955 307.7 MB
EGAF00005777307 1642695274659 273.3 MB
EGAF00005777308 1642695064797 285.7 MB
EGAF00005777309 1642695274659 293.4 MB
EGAF00005777310 1642695661939 305.9 MB
EGAF00005777311 1642673945773 322.6 MB
EGAF00005777312 1642673641353 349.8 MB
EGAF00005777313 1642695274659 336.2 MB
EGAF00005777314 1642695140271 351.8 MB
EGAF00005777315 1642673701630 336.8 MB
EGAF00005777316 1642673641353 350.2 MB
EGAF00005777317 1642695427094 382.6 MB
EGAF00005777318 1642695274659 401.1 MB
EGAF00005777319 1642674001038 298.1 MB
EGAF00005777320 1642674421262 334.6 MB
EGAF00005777321 1642673701630 285.8 MB
EGAF00005777322 1642674001038 300.7 MB
EGAF00005777323 1642695274660 343.1 MB
EGAF00005777324 1642673761444 360.2 MB
EGAF00005777325 1642673701630 333.6 MB
EGAF00005777326 1642709486968 349.1 MB
EGAF00005777327 1642673945773 569.5 MB
EGAF00005777328 1642695140271 596.1 MB
EGAF00005777329 1642695274659 310.5 MB
EGAF00005777330 1642674001038 330.1 MB
EGAF00005777331 1642673880955 308.2 MB
EGAF00005777332 1642673701630 328.9 MB
EGAF00005777333 1642673583404 286.7 MB
EGAF00005777334 1642673701630 301.0 MB
EGAF00005777335 1642674183366 437.9 MB
EGAF00005777336 1642673761444 455.4 MB
EGAF00005777337 1642695140273 301.7 MB
EGAF00005777338 1642695274659 314.5 MB
EGAF00005777339 1642673945773 322.8 MB
EGAF00005777340 1642673825515 339.0 MB
EGAF00005777341 1642673761444 602.4 MB
EGAF00005777342 1642673761444 633.2 MB
EGAF00005777343 1642709486968 253.3 MB
EGAF00005777344 1642673641353 266.3 MB
EGAF00005777345 1642673641353 375.0 MB
EGAF00005777346 1642673825515 391.6 MB
EGAF00005777347 1642673945773 583.4 MB
EGAF00005777348 1642674183366 610.0 MB
EGAF00005777349 1642673701630 363.7 MB
EGAF00005777350 1642674183366 381.9 MB
EGAF00005777351 1642673701630 325.8 MB
EGAF00005777352 1642673701630 342.6 MB
EGAF00005777353 1642696081238 304.6 MB
EGAF00005777354 1642695140271 324.0 MB
EGAF00005777355 1642673761444 811.2 MB
EGAF00005777356 1642673945773 851.4 MB
EGAF00005777357 1642673825515 362.4 MB
EGAF00005777358 1642673701630 377.9 MB
EGAF00005777359 1642673880955 803.2 MB
EGAF00005777360 1642674183366 846.0 MB
EGAF00005777361 1642676640249 251.8 MB
EGAF00005777362 1642676640249 303.4 MB
EGAF00005777363 1642676640249 380.1 MB
EGAF00005777364 1642676700025 778.3 MB
EGAF00005777365 1642676640249 349.2 MB
EGAF00005777366 1642676640249 326.3 MB
EGAF00005777367 1642676640249 296.9 MB
EGAF00005777368 1642676640249 317.1 MB
EGAF00005779668 1642943220058 464.3 kB
259 Files (109.8 GB)