Single nuclei sequencing of early, late-term, and early-onset pre-eclamptic decidua and villi.
Hypertensive disorders in pregnancy, of which the multisystem syndrome pre-eclampsia is the most severe, leading to preterm delivery, maternal mortality, and life-long complications. To elucidate early disease dynamics, we present the first spatio-temporal study comparing single-nuclei transcriptomes of human preterm pre-eclamptic placentae and healthy controls, contextualizing this in a comprehensive study including early and late gestational placentae. This study includes early placentae samples from the fetal part (villi; n=10), maternal part (Decidua; n=3), late placentae samples from healthy pregnancies, villi (n=6), decidua (n=4), and late placentae samples from early-onset preeclamptic pregnancies, villi (n=5) and decidua (n=5).
- 34 samples
- DAC: EGAC00001002364
- Technology: Illumina HiSeq 4000
Impaired cell interactions at the pre-eclamptic maternal-foetal interface.
The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. The User institution shall handle and store the Data in accordance with all applicable laws, governmental regulations, and guidelines pertaining the import, export, storage, use and disposal of data. 1. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 2. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 3. The Data are de-identified and cannot be used to re-identify the Research Patient. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that Data has been formally granted to the User Institution or is freely available without restriction. 4. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorized Personnel. The User Institution will not transfer or make available the Data in whole or in part for any secondary distribution to any person other than those within the Principal Investigator’s research group and for the declared and agreed use. 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In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005): https://www.govinfo.gov/content/pkg/FR-2005-04-11/pdf/05-7247.pdf in conformity with the Organization for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) : http://www.oecd.org/science/biotech/36198812.pdf . 9. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 10. The User Institution will notify MDC within 30 days of any changes or departures of Authorized Personnel. 11. The User Institution will notify MDC prior to any significant changes to the protocol for the Project. 12. The User Institution will notify MDC as soon as it becomes aware of a breach of the terms or conditions of this Agreement. 13. MDC may terminate this Agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 14. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this Agreement from time to time, including but not limited to specific provisions relating to the Data required by Data Producers other than MDC. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the Agreement. 15. 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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS00001005681 | Transcriptome Analysis |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Located in | |
|---|---|---|---|---|
| EGAF00005560966 | fastq.gz | 6.8 GB | ||
| EGAF00005560967 | fastq.gz | 18.5 GB | ||
| EGAF00005560968 | fastq.gz | 4.4 GB | ||
| EGAF00005560969 | fastq.gz | 15.6 GB | ||
| EGAF00005560970 | fastq.gz | 4.3 GB | ||
| EGAF00005560971 | fastq.gz | 14.8 GB | ||
| EGAF00005560972 | fastq.gz | 4.6 GB | ||
| EGAF00005560973 | fastq.gz | 15.9 GB | ||
| EGAF00005560974 | fastq.gz | 4.2 GB | ||
| EGAF00005560975 | fastq.gz | 14.7 GB | ||
| EGAF00005560976 | fastq.gz | 7.7 GB | ||
| EGAF00005560977 | fastq.gz | 20.5 GB | ||
| EGAF00005560978 | fastq.gz | 4.7 GB | ||
| EGAF00005560979 | fastq.gz | 12.9 GB | ||
| EGAF00005560980 | fastq.gz | 3.9 GB | ||
| EGAF00005560981 | fastq.gz | 13.6 GB | ||
| EGAF00005560982 | fastq.gz | 2.8 GB | ||
| EGAF00005560983 | fastq.gz | 10.3 GB | ||
| EGAF00005560984 | fastq.gz | 1.5 GB | ||
| EGAF00005560985 | fastq.gz | 5.4 GB | ||
| EGAF00005560986 | fastq.gz | 3.7 GB | ||
| EGAF00005560987 | fastq.gz | 13.0 GB | ||
| EGAF00005560988 | fastq.gz | 6.2 GB | ||
| EGAF00005560989 | fastq.gz | 16.1 GB | ||
| EGAF00005560990 | fastq.gz | 7.9 GB | ||
| EGAF00005560991 | fastq.gz | 7.8 GB | ||
| EGAF00005560992 | fastq.gz | 1.3 GB | ||
| EGAF00005560993 | fastq.gz | 4.2 GB | ||
| EGAF00005560994 | fastq.gz | 5.4 GB | ||
| EGAF00005560995 | fastq.gz | 2.9 GB | ||
| EGAF00005560996 | fastq.gz | 6.9 GB | ||
| EGAF00005560997 | fastq.gz | 18.2 GB | ||
| EGAF00005560998 | fastq.gz | 15.8 GB | ||
| EGAF00005560999 | fastq.gz | 9.0 GB | ||
| EGAF00005561000 | fastq.gz | 3.9 GB | ||
| EGAF00005561001 | fastq.gz | 13.8 GB | ||
| EGAF00005561002 | fastq.gz | 3.9 GB | ||
| EGAF00005561003 | fastq.gz | 13.8 GB | ||
| EGAF00005561004 | fastq.gz | 1.5 GB | ||
| EGAF00005561005 | fastq.gz | 5.4 GB | ||
| EGAF00005561006 | fastq.gz | 8.2 GB | ||
| EGAF00005561007 | fastq.gz | 22.5 GB | ||
| EGAF00005561008 | fastq.gz | 6.0 GB | ||
| EGAF00005561009 | fastq.gz | 16.4 GB | ||
| EGAF00007889753 | fastq.gz | 10.0 GB | ||
| EGAF00007889754 | fastq.gz | 11.6 GB | ||
| EGAF00007889755 | fastq.gz | 10.1 GB | ||
| EGAF00007889756 | fastq.gz | 24.0 GB | ||
| EGAF00007889757 | fastq.gz | 8.6 GB | ||
| EGAF00007889758 | fastq.gz | 19.6 GB | ||
| EGAF00007889759 | fastq.gz | 12.7 GB | ||
| EGAF00007889760 | fastq.gz | 29.0 GB | ||
| EGAF00007889761 | fastq.gz | 8.8 GB | ||
| EGAF00007889762 | fastq.gz | 19.7 GB | ||
| EGAF00007889763 | fastq.gz | 10.2 GB | ||
| EGAF00007889764 | fastq.gz | 23.1 GB | ||
| EGAF00007889765 | fastq.gz | 8.8 GB | ||
| EGAF00007889766 | fastq.gz | 19.9 GB | ||
| EGAF00007889767 | fastq.gz | 10.0 GB | ||
| EGAF00007889768 | fastq.gz | 21.8 GB | ||
| EGAF00007889769 | fastq.gz | 8.2 GB | ||
| EGAF00007889770 | fastq.gz | 17.8 GB | ||
| EGAF00007889771 | fastq.gz | 12.0 GB | ||
| EGAF00007889772 | fastq.gz | 25.8 GB | ||
| EGAF00007889773 | fastq.gz | 13.0 GB | ||
| EGAF00007889774 | fastq.gz | 29.6 GB | ||
| EGAF00007889775 | fastq.gz | 8.7 GB | ||
| EGAF00007889776 | fastq.gz | 19.5 GB | ||
| 68 Files (783.6 GB) | ||||