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Spatially confined sub-tumor microenvironments in pancreatic cancer

Intratumoral heterogeneity is a critical frontier in understanding how the tumor microenvironment (TME) propels malignant progression. Here, we deconvolute the human pancreatic TME through large-scale integration of histology-guided regional multiOMICs with clinical data and patient-derived preclinical models. We discover subTMEs, histologically definable tissue states anchored in fibroblast plasticity, with regional relationships to tumor immunity, subtypes, differentiation, and treatment response. Reactive subTMEs rich in complex but functionally coordinated fibroblast communities were immune-hot and inhabited by aggressive tumor cell phenotypes. The matrix-rich deserted subTMEs harbored less activated fibroblasts and tumor- suppressive features yet were markedly chemoprotective and enriched upon chemotherapy. SubTMEs originated in fibroblast differentiation trajectories and transitory states were notable both in single cell transcriptomics and in situ. The intratumoral co-occurrence of subTMEs produced patient-specific phenotypic and computationally predictable heterogeneity tightly linked to malignant biology. Therefore, heterogeneity within the plentiful, notorious pancreatic TME is not random but marks fundamental tissue organizational units.

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Please only click the "Request Access" button after the Data Access Agreement is fully executed. OICR-DAC manages genomic and transcriptomic data sets generated at the Ontario Institute for Cancer Research. 1. To access data, you must complete the OICR Data Access Agreement (DAA, see Policy Url above). Fields in red are mandatory. 2. The DAA should include the name(s) of all investigators who will download and/or analyze data. 3. All investigators must be from the same institution, and institutional email addresses must be used. 4. The DAA must be signed by an institutional signatory who has authority to bind the corporation. 5. Once completed, forward to OICR-DAC@oicr.on.ca for review. Data access will be granted upon final execution of the agreement. Note: To access and download data, each investigator must submit a “Request Access” form on the EGA website. A separate DAA is not required if they are already named on a fully executed DAA (as per above).

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002292672 bam 5.0 GB
EGAF00002292678 bam 2.8 GB
EGAF00002292679 bam 5.9 GB
EGAF00002292683 bam 2.9 GB
EGAF00002292693 bam 4.9 GB
EGAF00002292695 bam 3.7 GB
EGAF00002292696 bam 4.9 GB
EGAF00002292706 bam 6.9 GB
EGAF00002292709 bam 4.5 GB
EGAF00002292710 bam 6.7 GB
EGAF00002293345 bam 5.0 GB
EGAF00002293349 bam 5.4 GB
EGAF00002293353 bam 3.5 GB
EGAF00002293367 bam 6.4 GB
EGAF00002293369 bam 2.8 GB
EGAF00002293378 bam 11.5 GB
EGAF00002293401 bam 7.6 GB
EGAF00002293403 bam 5.2 GB
EGAF00002300222 fastq.gz 138.0 MB
EGAF00002300223 fastq.gz 131.9 MB
EGAF00002300226 fastq.gz 506.3 MB
EGAF00002300227 fastq.gz 508.6 MB
EGAF00002300228 fastq.gz 222.6 MB
EGAF00002300229 fastq.gz 225.6 MB
EGAF00002300246 fastq.gz 356.9 MB
EGAF00002300247 fastq.gz 354.6 MB
EGAF00002300250 fastq.gz 340.2 MB
EGAF00002300251 fastq.gz 349.4 MB
EGAF00002300322 fastq.gz 175.1 MB
EGAF00002300323 fastq.gz 164.8 MB
EGAF00002300328 fastq.gz 199.6 MB
EGAF00002300329 fastq.gz 211.6 MB
EGAF00002300330 fastq.gz 293.3 MB
EGAF00002300331 fastq.gz 284.6 MB
EGAF00002300346 fastq.gz 340.7 MB
EGAF00002300347 fastq.gz 358.5 MB
EGAF00002300354 fastq.gz 429.4 MB
EGAF00002300355 fastq.gz 445.7 MB
EGAF00002300362 fastq.gz 290.2 MB
EGAF00002300363 fastq.gz 294.8 MB
EGAF00002300506 fastq.gz 563.3 MB
EGAF00002300507 fastq.gz 556.1 MB
EGAF00002300508 fastq.gz 578.3 MB
EGAF00002300509 fastq.gz 575.9 MB
EGAF00002300518 fastq.gz 821.1 MB
EGAF00002300519 fastq.gz 865.3 MB
EGAF00002300532 fastq.gz 149.3 MB
EGAF00002300533 fastq.gz 150.9 MB
EGAF00002300544 fastq.gz 113.8 MB
EGAF00002300545 fastq.gz 113.0 MB
EGAF00002300546 fastq.gz 248.4 MB
EGAF00002300547 fastq.gz 225.7 MB
EGAF00002300554 fastq.gz 78.8 MB
EGAF00002300555 fastq.gz 77.7 MB
EGAF00002300568 fastq.gz 188.3 MB
EGAF00002300569 fastq.gz 179.1 MB
EGAF00002300572 fastq.gz 243.6 MB
EGAF00002300573 fastq.gz 246.7 MB
EGAF00002300604 fastq.gz 1.0 GB
EGAF00002300605 fastq.gz 1.1 GB
EGAF00002300612 fastq.gz 309.2 MB
EGAF00002300613 fastq.gz 326.1 MB
EGAF00002300618 fastq.gz 348.3 MB
EGAF00002300619 fastq.gz 364.3 MB
EGAF00002300652 fastq.gz 385.9 MB
EGAF00002300653 fastq.gz 351.0 MB
EGAF00002300668 fastq.gz 329.1 MB
EGAF00002300669 fastq.gz 348.0 MB
EGAF00002301238 bam 8.4 GB
EGAF00002301246 bam 7.9 GB
EGAF00002301251 bam 7.6 GB
EGAF00002301252 bam 5.8 GB
EGAF00002301349 bam 5.9 GB
EGAF00002301357 bam 4.7 GB
EGAF00002301359 bam 4.0 GB
EGAF00003212012 bam 6.1 GB
EGAF00003212013 bam 5.9 GB
EGAF00003247568 bam 7.3 GB
EGAF00003249718 fastq.gz 228.2 MB
EGAF00003249719 fastq.gz 229.6 MB
EGAF00003249918 fastq.gz 251.0 MB
EGAF00003249919 fastq.gz 250.6 MB
EGAF00003249972 fastq.gz 167.3 MB
EGAF00003249973 fastq.gz 166.0 MB
EGAF00003945157 bam 2.8 GB
EGAF00004169428 fastq.gz 284.3 MB
EGAF00004169429 fastq.gz 295.7 MB
EGAF00005488983 1632910596360 213.5 MB
EGAF00005488984 1632911314805 216.0 MB
EGAF00005488985 1632910596360 110.8 MB
EGAF00005488986 1632910596360 113.1 MB
EGAF00005488987 1632914318917 208.6 MB
EGAF00005488988 1632910242643 213.5 MB
EGAF00005488989 1632914318917 67.6 MB
EGAF00005488990 1632910596360 70.3 MB
EGAF00005488991 1632910242642 217.8 MB
EGAF00005488992 1632910242642 224.0 MB
EGAF00005488993 1632910242642 195.0 MB
EGAF00005488994 1632910413437 202.2 MB
EGAF00005488995 1632910242643 344.3 MB
EGAF00005488996 1632915284805 355.6 MB
EGAF00005488997 1632910017321 67.2 MB
EGAF00005488998 1632913970567 69.1 MB
EGAF00005488999 1632910242643 46.8 MB
EGAF00005489000 1632910596360 48.4 MB
EGAF00005489001 1632910952775 220.7 MB
EGAF00005489002 1632930780973 224.4 MB
EGAF00005489003 1632910596360 611.3 MB
EGAF00005489004 1632910596360 619.9 MB
EGAF00005489005 1632910786710 60.5 MB
EGAF00005489006 1632910413437 62.6 MB
EGAF00005489007 1632910242642 126.8 MB
EGAF00005489008 1632910596360 130.2 MB
EGAF00005489009 1632910596360 101.1 MB
EGAF00005489010 1632911144135 104.7 MB
EGAF00005489011 1632910952775 181.4 MB
EGAF00005489012 1632914138231 187.9 MB
EGAF00005489013 1632910242643 60.8 MB
EGAF00005489014 1632910242642 63.3 MB
EGAF00005489015 1632910242642 262.1 MB
EGAF00005489016 1632910786710 268.7 MB
EGAF00005489017 1632910242643 106.0 MB
EGAF00005489018 1632914138231 109.5 MB
EGAF00005489019 1632910596360 204.3 MB
EGAF00005489020 1632910625706 211.7 MB
EGAF00005489021 1632928456406 79.6 MB
EGAF00005489022 1632910242642 79.7 MB
EGAF00005489023 1632914511385 110.1 MB
EGAF00005489024 1632910413437 113.8 MB
EGAF00005489025 1632913970567 244.7 MB
EGAF00005489026 1632910242642 247.1 MB
EGAF00005489027 1632910596360 73.2 MB
EGAF00005489028 1632910786710 72.1 MB
EGAF00005489029 1632910242642 85.4 MB
EGAF00005489030 1632928867348 85.7 MB
EGAF00005489031 1632910242642 60.3 MB
EGAF00005489032 1632910242642 63.7 MB
EGAF00005489033 1632911144135 103.9 MB
EGAF00005489034 1632910786710 106.3 MB
EGAF00005489035 1632910786710 43.8 MB
EGAF00005489036 1632914138231 43.3 MB
EGAF00005489037 1632910952775 163.1 MB
EGAF00005489038 1632910786710 172.5 MB
EGAF00005489039 1632910413437 69.1 MB
EGAF00005489040 1632928456405 71.4 MB
EGAF00005492395 1632949723064 11.8 GB
EGAF00005492396 1632954896016 7.4 GB
EGAF00005492397 1632947570432 9.3 GB
EGAF00005492398 1632946951096 6.2 GB
EGAF00005492399 1632950572586 8.2 GB
EGAF00005492400 1632950572586 11.1 GB
EGAF00005492401 1632971300203 13.5 GB
EGAF00005492402 1632946366958 5.6 GB
EGAF00005492403 1632958028872 5.4 GB
EGAF00005492404 1632947296969 8.7 GB
EGAF00005492405 1632949153269 23.8 GB
EGAF00005492406 1632949723064 4.9 GB
EGAF00005492407 1632949723064 10.7 GB
EGAF00005492408 1632946951096 7.6 GB
EGAF00005492409 bam 6.9 GB
EGAF00005492410 bam 6.5 GB
EGAF00005492411 1632948905873 11.2 GB
EGAF00005492412 1632949989736 4.1 GB
EGAF00005492413 bam 5.9 GB
EGAF00005492414 1632946951096 4.7 GB
EGAF00005492415 1632950292450 6.1 GB
EGAF00005492416 bam 14.9 GB
EGAF00005492417 1632948905873 6.0 GB
EGAF00005492418 1632947570432 9.8 GB
EGAF00005492419 1632962074886 3.2 GB
EGAF00005492420 1632958317497 9.2 GB
EGAF00005492421 1632950292450 5.1 GB
EGAF00005492422 1632947296969 14.3 GB
EGAF00005492423 1632958317497 5.8 GB
174 Files (438.4 GB)