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Genomic characterization of co-existing biliary tract intraepithelial neoplasia and carcinoma lesions reveals distinct evolutionary paths of gallbladder cancer

Gallbladder carcinoma is the most common cancer of the biliary tract with dismal survival largely due to delayed diagnosis. Biliary tract intraepithelial neoplasia (BilIN) is the common benign tumor that is suspected to be precancerous lesions. However, the genetic and evolutionary relationships between BilIN and carcinoma remain unclear. Here we performed whole-exome sequencing of coexisting low-grade BilIN (adenoma), high-grade BilIN, and carcinoma lesions, and normal tissues from the same patients.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00005322197 1624263306761 1.1 GB
EGAF00005322198 1624263409433 1.5 GB
EGAF00005322199 1624263425895 1.1 GB
EGAF00005322200 1624263409433 1.5 GB
EGAF00005322201 1624263425895 1.1 GB
EGAF00005322202 1624263409433 1.5 GB
EGAF00005322203 1624263409433 1.1 GB
EGAF00005322204 1624263409433 1.5 GB
EGAF00005322205 1624263276626 1.1 GB
EGAF00005322206 1624263409433 1.5 GB
EGAF00005322207 1624263306761 1.1 GB
EGAF00005322208 1624263306761 1.5 GB
EGAF00005322209 1624263276626 1.1 GB
EGAF00005322210 1624263409434 1.5 GB
EGAF00005322211 1624263276626 1.1 GB
EGAF00005322212 1624263509267 1.5 GB
EGAF00005322213 1624263425895 1.1 GB
EGAF00005322214 1624263509267 1.5 GB
EGAF00005322215 1624263425895 1.1 GB
EGAF00005322216 1624263306761 1.5 GB
EGAF00005322217 1624263409433 1.1 GB
EGAF00005322218 1624263409433 1.5 GB
EGAF00005322219 1624263276626 1.1 GB
EGAF00005322220 1624263409433 1.5 GB
EGAF00005322221 1624263306761 1.1 GB
EGAF00005322222 1624263409433 1.5 GB
EGAF00005322223 1624263276626 1.1 GB
EGAF00005322224 1624263306761 1.5 GB
EGAF00005322225 1624263509267 1.1 GB
EGAF00005322226 1624263409433 1.5 GB
EGAF00005322227 1624263306761 1.1 GB
EGAF00005322228 1624275251878 1.5 GB
EGAF00005322229 1624263409433 1.1 GB
EGAF00005322230 1624263409433 1.5 GB
EGAF00005322231 1624263276626 1.1 GB
EGAF00005322232 1624263509267 1.5 GB
EGAF00005322233 1624263409433 1.1 GB
EGAF00005322234 1624263276626 1.5 GB
EGAF00005322235 1624263276626 1.1 GB
EGAF00005322236 1624263509267 1.5 GB
EGAF00005322237 1624263425895 1.1 GB
EGAF00005322238 1624263509267 1.5 GB
EGAF00005322239 1624263306761 1.1 GB
EGAF00005322240 1624263276626 1.5 GB
EGAF00005322241 1624263276626 1.1 GB
EGAF00005322242 1624275251878 1.5 GB
EGAF00005322243 1624263409433 1.1 GB
EGAF00005322244 1624275251878 1.5 GB
EGAF00005322245 1624263409433 1.1 GB
EGAF00005322246 1624263276626 1.5 GB
EGAF00005322247 1625003704680 1.1 GB
EGAF00005322248 1625005076457 1.5 GB
EGAF00005322249 1624263409433 1.1 GB
EGAF00005322250 1624263276626 1.5 GB
EGAF00005322251 1624263409433 1.1 GB
EGAF00005322252 1624263306761 1.5 GB
EGAF00005322253 1624263276626 1.1 GB
EGAF00005322254 1624263409433 1.5 GB
EGAF00005322255 1624263276626 1.1 GB
EGAF00005322256 1624263425895 1.5 GB
EGAF00005322257 1624263276626 1.1 GB
EGAF00005322258 1624263425895 1.5 GB
EGAF00005322259 1624263409433 1.1 GB
EGAF00005322260 1624263306761 1.5 GB
EGAF00005322261 1624275251878 1.1 GB
EGAF00005322262 1624263276626 1.5 GB
EGAF00005322263 1624263409433 1.1 GB
EGAF00005322264 1624263509267 1.5 GB
EGAF00005322265 1624263276626 1.1 GB
EGAF00005322266 1624263276626 1.5 GB
EGAF00005322267 1624275251878 1.1 GB
EGAF00005322268 1624263276626 1.5 GB
EGAF00005322269 1624263306761 1.1 GB
EGAF00005322270 1624275251878 1.5 GB
EGAF00005322271 1624263276626 1.1 GB
EGAF00005322272 1624263409433 1.5 GB
EGAF00005322273 1624263276626 1.1 GB
EGAF00005322274 1624263306761 1.5 GB
EGAF00005322275 1624263276626 1.1 GB
EGAF00005322276 1624263409433 1.5 GB
EGAF00005322277 1624263409433 1.1 GB
EGAF00005322278 1624263425895 1.5 GB
EGAF00005322279 1624263276626 1.1 GB
EGAF00005322280 1624263409433 1.5 GB
EGAF00005322281 1624263409433 1.1 GB
EGAF00005322282 1624263409433 1.5 GB
EGAF00005322283 1624263425895 1.1 GB
EGAF00005322284 1624263409433 1.5 GB
88 Files (113.5 GB)