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IL7RA activated cord blood derived leukemia

Whole exome sequencing of cord bloods with activated IL7RA leading to leukemia outgrowth in NSG mice. Four leukemia and two corresponding normal controls were sequenced on an Illumina Nextseq550 sequencer (paired end 2x 150 bp).

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The deposited data are whole exome sequencing (WES) datasets. To explore the consequences of aberrant IL7RA signaling activation in human hematopoietic progenitors on malignant B-cell development human cord-blood hematopoietic progenitors transduced with activated mutant IL7RA and transplanted into into NOD/LtSz-scid IL2RĪ³null mice. Activation of IL7RA signaling enhanced self-renewal and facilitated the development of a BCP-ALL in secondary transplanted mice. The development of leukemia was associated with spontaneous acquired deletions in CDKN2A/B and IKZF1 similar to what is observed in Ph-like BCP-ALL in humans. WES datasets of four leukemias and two correspoding normal controls are deposited.

The deposited data can be accessed for research purposes only. Permission has to be obtained from Prof. Shai Izraeli at Schneider Children's Medical Center of Israel: Petah Tikva, IL.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00005309040 1622568509424 11.6 GB
EGAF00005309041 1622570805985 12.1 GB
EGAF00005309042 bam 13.7 GB
EGAF00005309043 1622569836349 10.9 GB
EGAF00005309044 1622570805985 15.2 GB
EGAF00005309045 1622569866193 10.8 GB
6 Files (74.3 GB)