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Alloreactive T-cell receptor (TCR) repertoire in kidney transplantation

We analyzed the T-cell receptor (TCR) repertoires from twelve kidney transplant recipients. Six out of the twelve kidney transplant recipients experienced a cellular rejection after kidney transplantation. TCR repertoires of CD4+ and CD8+ positive T-cells were assessed prior to transplantation and after transplantation at time of allograft biopsy using RNA based T-cell receptor beta next generation sequencing (NGS). In addition, the pre-formed alloreactive TCR repertoire for each kidney transplant recipient was identified using mixed lymphocyte reaction and donor reactive T-cells were subjected to TCR beta sequencing. In two out of the six patients with cellular rejection the TCR repertoire of graft infiltrating T-cells was additionally captured. This dataset comprises a total of 98 samples. NGS TCR beta libraries of all samples were sequenced on an Illumina NextSeq 500 and raw sequencing data (in the form of fastq files) as well assembled clonotypes and their counts (in the form of clonotype tables) are provided.

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Study ID Study Title Study Type
Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00005298853 1621004886666 286.8 MB
EGAF00005298854 1621004946889 460.1 MB
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EGAF00005298858 1621087870882 740.8 MB
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EGAF00005298869 1621087936428 389.3 MB
EGAF00005298870 1621087816323 587.9 MB
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EGAF00005298874 1621088112913 639.9 MB
EGAF00005298875 1621088537250 979.1 MB
EGAF00005298876 1621088600713 1.5 GB
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EGAF00005298889 1621087936428 232.3 MB
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EGAF00005298893 1621088112913 256.1 MB
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EGAF00005298897 1621087816323 228.1 MB
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EGAF00005298901 1621087816323 416.6 MB
EGAF00005298902 1621088178459 667.7 MB
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EGAF00005298904 1621088178459 442.1 MB
EGAF00005298905 1621087936428 327.0 MB
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EGAF00005298907 1621088000103 274.7 MB
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EGAF00005298916 1621087936428 482.5 MB
EGAF00005298917 1621087870882 416.1 MB
EGAF00005298918 1621088361059 633.2 MB
EGAF00005298919 1621088052562 390.8 MB
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EGAF00005298921 1621088000103 475.4 MB
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EGAF00005298924 1621087816323 433.6 MB
EGAF00005298925 1621088112913 327.6 MB
EGAF00005298926 1621088234103 474.8 MB
EGAF00005298927 1621087696797 1.2 kB
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EGAF00005298929 1621088112913 376.4 MB
EGAF00005298930 1621087870882 522.3 MB
EGAF00005298931 1621087870882 425.7 MB
EGAF00005298932 1621087870882 678.3 MB
EGAF00005298933 1621088361059 350.0 MB
EGAF00005298934 1621088292990 526.7 MB
EGAF00005298935 1621088234103 379.9 MB
EGAF00005298936 1621088112913 604.5 MB
EGAF00005298937 1621088000103 261.9 MB
EGAF00005298938 1621088000103 405.5 MB
EGAF00005298939 1621088000103 402.8 MB
EGAF00005298940 1621088537250 565.0 MB
EGAF00005298941 1621088472030 408.9 MB
EGAF00005298942 1621088052562 607.4 MB
EGAF00005298943 1621088409319 471.9 MB
EGAF00005298944 1621088292990 730.8 MB
EGAF00005298945 1621088112913 455.7 MB
EGAF00005298946 1621088052562 676.9 MB
EGAF00005298947 1621088361059 454.0 MB
EGAF00005298948 1621088409319 698.1 MB
EGAF00005298949 1621087870882 443.2 MB
EGAF00005298950 1621088409319 709.7 MB
EGAF00005298951 1621088112913 440.8 MB
EGAF00005298952 1621088178459 687.6 MB
EGAF00005298953 1621088234103 389.5 MB
EGAF00005298954 1621088537250 622.9 MB
EGAF00005298955 1621088292990 489.6 MB
EGAF00005298956 1621088361059 761.2 MB
EGAF00005298957 1621088000103 310.7 MB
EGAF00005298958 1621091473796 470.0 MB
EGAF00005298959 1621088112913 530.5 MB
EGAF00005298960 1621088112913 792.9 MB
EGAF00005298961 1621088178459 397.3 MB
EGAF00005298962 1621088000103 596.2 MB
EGAF00005298963 1621088052562 393.5 MB
EGAF00005298964 1621088361059 590.2 MB
EGAF00005298965 1621087816323 29.9 MB
EGAF00005298966 1621087754166 40.8 MB
EGAF00005298967 1621088052562 484.0 MB
EGAF00005298968 1621088000103 676.1 MB
EGAF00005298969 1621088178459 623.2 MB
EGAF00005298970 1621088052562 959.6 MB
EGAF00005298971 1621087816323 455.8 MB
EGAF00005298972 1621088537250 720.7 MB
EGAF00005298973 1621088292990 287.9 MB
EGAF00005298974 1621088000103 383.1 MB
EGAF00005298975 1621088292990 350.8 MB
EGAF00005298976 1621088052562 502.9 MB
EGAF00005298977 1621087870882 287.3 MB
EGAF00005298978 1621088000103 458.5 MB
EGAF00005298979 1621088234103 1.2 GB
EGAF00005298980 1621088409319 1.7 GB
EGAF00005298981 1621088000103 520.0 MB
EGAF00005298982 1621088600713 726.7 MB
EGAF00005298983 1621088000103 383.4 MB
EGAF00005298984 1621088112913 547.5 MB
EGAF00005298985 1621087936428 403.7 MB
EGAF00005298986 1621088472030 647.9 MB
EGAF00005298987 1621088112913 416.4 MB
EGAF00005298988 1621091534158 635.4 MB
EGAF00005298989 1621088472030 467.5 MB
EGAF00005298990 1621088178459 686.7 MB
EGAF00005298991 1621088052562 392.8 MB
EGAF00005298992 1621088000103 562.9 MB
EGAF00005298993 1621088000103 243.7 MB
EGAF00005298994 1621088292990 362.0 MB
EGAF00005298995 1621088178459 364.2 MB
EGAF00005298996 1621088052562 534.5 MB
EGAF00005298997 1621088052562 434.5 MB
EGAF00005298998 1621088409319 597.1 MB
EGAF00005298999 1621088472030 523.7 MB
EGAF00005299000 1621088052562 762.8 MB
EGAF00005299001 1621088361059 457.1 MB
EGAF00005299002 1621088052562 660.5 MB
EGAF00005299003 1621087754166 425.8 MB
EGAF00005299004 1621087870882 691.0 MB
EGAF00005299005 1621087816323 543.0 MB
EGAF00005299006 1621088178459 818.2 MB
EGAF00005299007 1621088052562 412.2 MB
EGAF00005299008 1621088112913 623.9 MB
EGAF00005299009 1621088292990 483.7 MB
EGAF00005299010 1621088537250 757.4 MB
EGAF00005299011 1621088234103 330.8 MB
EGAF00005299012 1621088409319 472.0 MB
EGAF00005299013 1621087936428 519.7 MB
EGAF00005299014 1621088600713 875.4 MB
EGAF00005299015 1621088361059 442.4 MB
EGAF00005299016 1621087936428 678.2 MB
EGAF00005299017 1621088361059 386.3 MB
EGAF00005299018 1621088112913 607.7 MB
EGAF00005299019 1621088000103 501.1 MB
EGAF00005299020 1621088537250 787.8 MB
EGAF00005299021 1621088052562 271.3 MB
EGAF00005299022 1621088472030 422.7 MB
EGAF00005299023 1621088052562 360.8 MB
EGAF00005299024 1621091473796 553.1 MB
EGAF00005299025 1621088000103 321.0 MB
EGAF00005299026 1621088178459 500.1 MB
EGAF00005299027 1621087696797 364.1 MB
EGAF00005299028 1621087936428 583.1 MB
EGAF00005299029 1621088292990 402.8 MB
EGAF00005299030 1621088178459 646.9 MB
EGAF00005299031 1621087816323 297.9 MB
EGAF00005299032 1621088292990 467.4 MB
EGAF00005299033 1621088292990 537.6 MB
EGAF00005299034 1621087936428 789.6 MB
EGAF00005299035 1621088000103 386.4 MB
EGAF00005299036 1621087936428 564.5 MB
EGAF00005299037 1621088000103 845.3 MB
EGAF00005299038 1621088361059 1.3 GB
EGAF00005299039 1621087754166 291.4 MB
EGAF00005299040 1621088292990 447.3 MB
EGAF00005299041 1621087696797 328.6 MB
EGAF00005299042 1621088052562 526.7 MB
EGAF00005299043 1621088178459 409.4 MB
EGAF00005299044 1621088178459 639.4 MB
EGAF00005299045 1621087816323 605.0 MB
EGAF00005299046 1621088178459 844.2 MB
EGAF00005299047 1621087696797 338.1 MB
EGAF00005299048 1621088052562 530.8 MB
EGAF00005299049 1621087696797 90.4 kB
EGAF00005299050 1621087631825 1.8 MB
EGAF00005299051 1621087754166 169.6 kB
EGAF00005299052 1621087631825 6.9 MB
EGAF00005299053 1621087631825 9.1 MB
EGAF00005299054 1621087631825 5.5 MB
EGAF00005299055 1621087631825 8.4 MB
EGAF00005299056 1621087936428 436.2 kB
EGAF00005299057 1621087631825 12.7 MB
EGAF00005299058 1621087631825 10.3 MB
EGAF00005299059 1621087754166 2.9 MB
EGAF00005299060 1621087754166 7.0 MB
EGAF00005299061 1621087816323 17.5 MB
EGAF00005299062 1621088000103 4.7 MB
EGAF00005299063 1621087696797 7.2 MB
EGAF00005299064 1621087754166 1.9 MB
EGAF00005299065 1621087631825 22.1 MB
EGAF00005299066 1621087631825 1.5 MB
EGAF00005299067 1621087631825 16.7 MB
EGAF00005299068 1621087936428 4.2 MB
EGAF00005299069 1621087870882 25.8 MB
EGAF00005299070 1621087870882 21.3 MB
EGAF00005299071 1621087816323 19.2 MB
EGAF00005299072 1621087631825 15.4 MB
EGAF00005299073 1621087816323 7.1 MB
EGAF00005299074 1621087816323 3.4 MB
EGAF00005299075 1621087696798 1.2 MB
EGAF00005299076 1621087696798 9.7 MB
EGAF00005299077 1621087696798 10.5 MB
EGAF00005299078 1621087936428 2.4 MB
EGAF00005299079 1621087754165 19.4 MB
EGAF00005299080 1621087870882 8.3 MB
EGAF00005299081 1621087696798 2.3 MB
EGAF00005299082 1621087696797 20.7 MB
EGAF00005299083 1621087816323 9.9 MB
EGAF00005299084 1621087696797 10.1 MB
EGAF00005299085 1621087696797 4.3 MB
EGAF00005299086 1621087696797 271.3 kB
EGAF00005299087 1621087696797 1.0 MB
EGAF00005299088 1621087870882 1.3 MB
EGAF00005299089 1621087754166 10.4 MB
EGAF00005299090 1621087754166 5.9 MB
EGAF00005299091 1621087754166 4.0 MB
EGAF00005299092 1621087870882 16.1 MB
EGAF00005299093 1621087696797 15.0 MB
EGAF00005299094 1621087754166 182.4 kB
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EGAF00005299103 1621087754166 1.8 MB
EGAF00005299104 1621087936428 413.8 kB
EGAF00005299105 1621087696797 460.8 kB
EGAF00005299106 1621087870882 21.4 MB
EGAF00005299107 1621087754166 17.6 MB
EGAF00005299108 1621087870882 20.3 MB
EGAF00005299109 1621087696797 433 Bytes
EGAF00005299110 1621087696797 1.9 MB
EGAF00005299111 1621087696797 863.4 kB
EGAF00005299112 1621087936428 933.9 kB
EGAF00005299113 1621087696797 2.0 MB
EGAF00005299114 1621087870882 169 Bytes
EGAF00005299115 1621087936428 2.4 MB
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EGAF00005299131 1621087696797 13.8 MB
EGAF00005299132 1621087696797 1.0 MB
EGAF00005299133 1621087754166 3.3 MB
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EGAF00005299142 1621087696797 788.2 kB
EGAF00005299143 1621088000103 381.1 kB
EGAF00005299144 1621087870882 9.1 MB
EGAF00005299145 1621087696797 171.4 kB
EGAF00005299146 1621087816323 331.3 kB
294 Files (99.7 GB)