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atrial appendage RNA-seq in non-, paroxysmal and persistent atrial fibrillation

64 left atrial appendages from patients without atrial fibrillation (AF) undergoing cardiac surgery, patients with paroxysmal AF and with persistent AF (~20 per group). Trizol RNA isolation, rRNA depletion, paired transcriptome sequencing on illumina NovaSeq 6000. Provided are FastQ and BAM files. Additional data (e.g. clinical characteristics, RIN values etc.) can be provided upon reasonable request. The same RNA samples (62 out of 64) were used for miRNA sequencing. Results from miRNA seuqencing are stored in the EGA database managed by the same DAC.

Request Access

Adjusted standard DAA specified end-term and annual report specified restrictions concerning conflict of interest

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom the Amsterdam University Medical Center, Heart Center grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: The Amsterdam University Medical Center, Heart Center and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project or once the end of the term of data access is reached, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify the Amsterdam University Medical Center, Heart Center within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify the Amsterdam University Medical Center, Heart Center prior to any significant changes to the aims or protocol for the Project. 14. The User Institution will notify the Amsterdam University Medical Center, Heart Center as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. The Amsterdam University Medical Center, Heart Center may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than the Amsterdam University Medical Center, Heart Center. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of England and Wales and shall be subject to the exclusive jurisdiction of the English courts. 20. The term of data access is terminated after 4 years unless an extension request is approved. The User Institution aims to finish the project for which the data is being used within 4 years since the day from which the access to the data was granted. A request for an extension of this period may be submitted to the Amsterdam University Medical Center, Heart Center no more than a month prior to the end of the agreement period. 21. The User Institution will notify the Amsterdam University Medical Center, Heart Center yearly about the progress of the project. This report should explain how the data is used, i.e., the dissemination of the data, such as in conferences or reports, and the progress achieved from the utilization of these data. Agreed for User Institution Signature: Name: Title: Date: Principal Investigator I confirm that I have read and understood this Agreement. Signature: Name: Title: Date: Agreed for the Amsterdam University Medical Center, Heart Center Signature: Name: Title: Date: APPENDIX I – DATASET DETAILS APPENDIX II ––PROJECT DETAILS APPENDIX III –– PUBLICATION POLICY APPENDIX I – DATASET DETAILS (to be completed by the data producer before passing to applicant) Dataset reference (EGA Study ID and Dataset Details) Name of project that created the dataset Names of other data producers/collaborators Specific limitations on areas of research The application or amendments may be rejected if the use of the data by the User Institution presents a competing interest for research performed by the Amsterdam University Medical Center, Heart Center. Minimum protection measures required File access: Data can be held in unencrypted files on an institutional compute system, with Unix user group read/write access for one or more appropriate groups but not Unix world read/write access behind a secure firewall. Laptops holding these data should have password protected logins and screenlocks (set to lock after 5 min of inactivity). If held on USB keys or other portable hard drives, the data must be encrypted. APPENDIX II – PROJECT DETAILS (to be completed by the Requestor) Details of dataset requested i.e., EGA Study and Dataset Accession Number Brief abstract of the Project in which the Data will be used, including project aims (500 words max) All Individuals who the User Institution to be named as registered users Name of Registered User Email Job Title Supervisor* All Individuals that should have an account created at the EGA Name of Registered User Email Job Title APPENDIX III – PUBLICATION POLICY The Amsterdam University Medical Center, Heart Center intend to publish the results of their analysis of this dataset and do not consider its deposition into public databases to be the equivalent of such publications. The Amsterdam University Medical Center, Heart Center anticipate that the dataset could be useful to other qualified researchers for a variety of purposes. However, some areas of work are subject to a publication moratorium. The publication moratorium covers any publications (including oral communications) that describe the use of the dataset. For research papers, submission for publication should not occur until 8 months after these data were first made available on the relevant hosting database, unless The Amsterdam University Medical Center, Heart Center has provided written consent to earlier submission. In any publications based on these data, please describe how the data can be accessed, including the name of the hosting database (e.g., The European Genome-phenome Archive at the European Bioinformatics Institute) and its accession numbers (e.g., EGAS00000000029), and acknowledge its use in a form agreed by the User Institution with The Amsterdam University Medical Center, Heart Center.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001005295 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00005295922 fastq.gz 2.6 GB
EGAF00005295923 fastq.gz 2.7 GB
EGAF00005295924 bam 4.0 GB
EGAF00005295925 bam 4.4 GB
EGAF00005295926 fastq.gz 2.5 GB
EGAF00005295927 fastq.gz 2.6 GB
EGAF00005295928 fastq.gz 2.6 GB
EGAF00005295929 fastq.gz 2.7 GB
EGAF00005295930 bam 3.6 GB
EGAF00005295931 fastq.gz 2.3 GB
EGAF00005295932 fastq.gz 2.4 GB
EGAF00005295933 bam 3.4 GB
EGAF00005295934 fastq.gz 2.6 GB
EGAF00005295935 fastq.gz 2.6 GB
EGAF00005295936 fastq.gz 3.2 GB
EGAF00005295937 fastq.gz 3.3 GB
EGAF00005295938 bam 4.7 GB
EGAF00005295939 bam 4.0 GB
EGAF00005295940 fastq.gz 1.8 GB
EGAF00005295941 fastq.gz 1.9 GB
EGAF00005295942 fastq.gz 3.3 GB
EGAF00005295943 fastq.gz 3.5 GB
EGAF00005295944 fastq.gz 2.8 GB
EGAF00005295945 fastq.gz 2.9 GB
EGAF00005295946 bam 3.5 GB
EGAF00005295947 fastq.gz 2.3 GB
EGAF00005295948 fastq.gz 2.4 GB
EGAF00005295949 fastq.gz 2.6 GB
EGAF00005295950 fastq.gz 2.7 GB
EGAF00005295951 bam 3.5 GB
EGAF00005295952 fastq.gz 2.5 GB
EGAF00005295953 fastq.gz 2.6 GB
EGAF00005295954 fastq.gz 2.7 GB
EGAF00005295955 fastq.gz 2.8 GB
EGAF00005295956 bam 3.6 GB
EGAF00005295957 fastq.gz 2.4 GB
EGAF00005295958 fastq.gz 2.4 GB
EGAF00005295959 fastq.gz 2.4 GB
EGAF00005295960 fastq.gz 2.5 GB
EGAF00005295961 fastq.gz 2.2 GB
EGAF00005295962 fastq.gz 2.4 GB
EGAF00005295963 fastq.gz 1.9 GB
EGAF00005295964 fastq.gz 2.0 GB
EGAF00005295965 fastq.gz 2.5 GB
EGAF00005295966 fastq.gz 2.6 GB
EGAF00005295967 fastq.gz 2.9 GB
EGAF00005295968 fastq.gz 3.0 GB
EGAF00005295969 fastq.gz 2.4 GB
EGAF00005295970 fastq.gz 2.5 GB
EGAF00005295971 fastq.gz 2.5 GB
EGAF00005295972 fastq.gz 2.6 GB
EGAF00005295973 bam 3.1 GB
EGAF00005295974 bam 4.6 GB
EGAF00005295975 bam 3.6 GB
EGAF00005295976 bam 3.7 GB
EGAF00005295977 bam 3.5 GB
EGAF00005295978 bam 4.3 GB
EGAF00005295979 fastq.gz 2.4 GB
EGAF00005295980 fastq.gz 2.4 GB
EGAF00005295981 fastq.gz 2.9 GB
EGAF00005295982 fastq.gz 2.9 GB
EGAF00005295983 fastq.gz 2.8 GB
EGAF00005295984 fastq.gz 2.9 GB
EGAF00005295985 fastq.gz 3.0 GB
EGAF00005295986 fastq.gz 3.2 GB
EGAF00005295987 fastq.gz 2.6 GB
EGAF00005295988 fastq.gz 2.7 GB
EGAF00005295989 fastq.gz 2.5 GB
EGAF00005295990 fastq.gz 2.7 GB
EGAF00005295991 bam 4.0 GB
EGAF00005295992 fastq.gz 3.1 GB
EGAF00005295993 fastq.gz 3.2 GB
EGAF00005295994 bam 3.9 GB
EGAF00005295995 fastq.gz 2.9 GB
EGAF00005295996 fastq.gz 3.0 GB
EGAF00005295997 bam 3.3 GB
EGAF00005295998 bam 3.8 GB
EGAF00005295999 fastq.gz 2.7 GB
EGAF00005296000 fastq.gz 2.8 GB
EGAF00005296001 bam 3.4 GB
EGAF00005296002 fastq.gz 3.4 GB
EGAF00005296003 fastq.gz 3.5 GB
EGAF00005296004 fastq.gz 2.7 GB
EGAF00005296005 fastq.gz 2.7 GB
EGAF00005296006 bam 3.6 GB
EGAF00005296007 bam 3.9 GB
EGAF00005296008 fastq.gz 2.2 GB
EGAF00005296009 fastq.gz 2.3 GB
EGAF00005296010 fastq.gz 3.0 GB
EGAF00005296011 fastq.gz 3.2 GB
EGAF00005296012 fastq.gz 2.5 GB
EGAF00005296013 fastq.gz 2.6 GB
EGAF00005296014 bam 4.4 GB
EGAF00005296015 bam 4.1 GB
EGAF00005296016 fastq.gz 2.5 GB
EGAF00005296017 fastq.gz 2.7 GB
EGAF00005296018 fastq.gz 3.4 GB
EGAF00005296019 fastq.gz 3.5 GB
EGAF00005296020 fastq.gz 3.2 GB
EGAF00005296021 fastq.gz 3.3 GB
EGAF00005296022 fastq.gz 2.8 GB
EGAF00005296023 fastq.gz 2.9 GB
EGAF00005296024 bam 4.0 GB
EGAF00005296025 bam 4.7 GB
EGAF00005296026 bam 3.1 GB
EGAF00005296027 fastq.gz 2.7 GB
EGAF00005296028 fastq.gz 2.9 GB
EGAF00005296029 fastq.gz 2.1 GB
EGAF00005296030 fastq.gz 2.2 GB
EGAF00005296031 bam 3.5 GB
EGAF00005296032 bam 3.1 GB
EGAF00005296033 bam 3.8 GB
EGAF00005296034 fastq.gz 2.9 GB
EGAF00005296035 fastq.gz 3.1 GB
EGAF00005296036 bam 3.4 GB
EGAF00005296037 bam 3.4 GB
EGAF00005296038 bam 3.2 GB
EGAF00005296039 fastq.gz 2.4 GB
EGAF00005296040 fastq.gz 2.5 GB
EGAF00005296041 bam 3.7 GB
EGAF00005296042 fastq.gz 2.6 GB
EGAF00005296043 fastq.gz 2.7 GB
EGAF00005296044 bam 2.7 GB
EGAF00005296045 fastq.gz 2.3 GB
EGAF00005296046 fastq.gz 2.5 GB
EGAF00005296047 bam 4.2 GB
EGAF00005296048 bam 3.7 GB
EGAF00005296049 bam 3.6 GB
EGAF00005296050 bam 3.6 GB
EGAF00005296051 fastq.gz 2.7 GB
EGAF00005296052 fastq.gz 2.8 GB
EGAF00005296053 bam 3.0 GB
EGAF00005296054 bam 3.9 GB
EGAF00005296055 fastq.gz 2.1 GB
EGAF00005296056 fastq.gz 2.2 GB
EGAF00005296057 bam 3.8 GB
EGAF00005296058 bam 3.3 GB
EGAF00005296059 fastq.gz 2.4 GB
EGAF00005296060 fastq.gz 2.5 GB
EGAF00005296061 bam 3.8 GB
EGAF00005296062 fastq.gz 2.5 GB
EGAF00005296063 fastq.gz 2.6 GB
EGAF00005296064 bam 3.1 GB
EGAF00005296065 fastq.gz 2.4 GB
EGAF00005296066 fastq.gz 2.5 GB
EGAF00005296067 bam 3.6 GB
EGAF00005296068 bam 3.4 GB
EGAF00005296069 fastq.gz 2.7 GB
EGAF00005296070 fastq.gz 2.8 GB
EGAF00005296071 bam 3.7 GB
EGAF00005296072 fastq.gz 3.5 GB
EGAF00005296073 fastq.gz 3.6 GB
EGAF00005296074 fastq.gz 1.8 GB
EGAF00005296075 fastq.gz 1.8 GB
EGAF00005296076 bam 4.7 GB
EGAF00005296077 bam 4.0 GB
EGAF00005296078 bam 4.1 GB
EGAF00005296079 fastq.gz 2.6 GB
EGAF00005296080 fastq.gz 2.7 GB
EGAF00005296081 fastq.gz 2.1 GB
EGAF00005296082 fastq.gz 2.2 GB
EGAF00005296083 fastq.gz 2.3 GB
EGAF00005296084 fastq.gz 2.4 GB
EGAF00005296085 bam 3.8 GB
EGAF00005296086 bam 3.3 GB
EGAF00005296087 bam 2.8 GB
EGAF00005296088 bam 4.9 GB
EGAF00005296089 bam 2.6 GB
EGAF00005296090 fastq.gz 2.2 GB
EGAF00005296091 fastq.gz 2.3 GB
EGAF00005296092 fastq.gz 2.0 GB
EGAF00005296093 fastq.gz 2.1 GB
EGAF00005296094 bam 4.4 GB
EGAF00005296095 bam 3.2 GB
EGAF00005296096 fastq.gz 2.7 GB
EGAF00005296097 fastq.gz 2.8 GB
EGAF00005296098 bam 2.9 GB
EGAF00005296099 fastq.gz 2.2 GB
EGAF00005296100 fastq.gz 2.2 GB
EGAF00005296101 fastq.gz 2.3 GB
EGAF00005296102 fastq.gz 2.4 GB
EGAF00005296103 bam 3.8 GB
EGAF00005296104 fastq.gz 2.6 GB
EGAF00005296105 fastq.gz 2.7 GB
EGAF00005296106 fastq.gz 2.4 GB
EGAF00005296107 fastq.gz 2.5 GB
EGAF00005296108 bam 3.7 GB
EGAF00005296109 bam 3.7 GB
EGAF00005296110 fastq.gz 2.7 GB
EGAF00005296111 fastq.gz 2.8 GB
EGAF00005296112 bam 3.8 GB
EGAF00005296113 bam 3.6 GB
EGAF00005296490 bai 3.5 MB
EGAF00005296491 bai 3.5 MB
EGAF00005296492 bai 3.2 MB
EGAF00005296493 bai 3.6 MB
EGAF00005296494 bai 3.5 MB
EGAF00005296495 bai 3.9 MB
EGAF00005296496 bai 3.6 MB
EGAF00005296497 bai 3.8 MB
EGAF00005296498 bai 3.6 MB
EGAF00005296499 bai 3.5 MB
EGAF00005296500 bai 3.1 MB
EGAF00005296501 bai 3.4 MB
EGAF00005296502 bai 3.7 MB
EGAF00005296503 bai 3.2 MB
EGAF00005296504 bai 3.5 MB
EGAF00005296505 bai 3.7 MB
EGAF00005296506 bai 3.8 MB
EGAF00005296507 bai 3.6 MB
EGAF00005296508 bai 3.5 MB
EGAF00005296509 bai 3.7 MB
EGAF00005296510 bai 3.3 MB
EGAF00005296511 bai 3.4 MB
EGAF00005296512 bai 3.7 MB
EGAF00005296513 bai 3.7 MB
EGAF00005296514 bai 3.8 MB
EGAF00005296515 bai 3.5 MB
EGAF00005296516 bai 3.7 MB
EGAF00005296517 bai 3.6 MB
EGAF00005296518 bai 3.1 MB
EGAF00005296519 bai 3.6 MB
EGAF00005296520 bai 3.2 MB
EGAF00005296521 bai 3.6 MB
EGAF00005296522 bai 3.8 MB
EGAF00005296523 bai 3.7 MB
EGAF00005296524 bai 3.6 MB
EGAF00005296525 bai 3.6 MB
EGAF00005296526 bai 3.5 MB
EGAF00005296527 bai 3.9 MB
EGAF00005296528 bai 3.8 MB
EGAF00005296529 bai 3.7 MB
EGAF00005296530 bai 3.6 MB
EGAF00005296531 bai 3.2 MB
EGAF00005296532 bai 3.6 MB
EGAF00005296533 bai 3.1 MB
EGAF00005296534 bai 3.7 MB
EGAF00005296535 bai 3.7 MB
EGAF00005296536 bai 3.4 MB
EGAF00005296537 bai 3.5 MB
EGAF00005296538 bai 3.0 MB
EGAF00005296539 bai 3.7 MB
EGAF00005296540 bai 3.7 MB
EGAF00005296541 bai 3.6 MB
EGAF00005296542 bai 3.7 MB
EGAF00005296543 bai 3.5 MB
EGAF00005296544 bai 3.4 MB
EGAF00005296545 bai 3.8 MB
EGAF00005296546 bai 3.7 MB
EGAF00005296547 bai 3.8 MB
EGAF00005296548 bai 3.4 MB
EGAF00005296549 bai 3.7 MB
EGAF00005296550 bai 3.7 MB
EGAF00005296551 bai 3.4 MB
EGAF00005296552 bai 3.5 MB
EGAF00005296553 bai 3.7 MB
256 Files (572.1 GB)