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Evolutionary trajectories and clonal migration underlying tumor progression and lymph node metastasis in resectable lung cancer

In this prospective study, targeted deep sequencing was performed on a total of 160 primary tumors (474 regions) and 112 lymph nodes from 125 patients with stage I-III lung cancer (LuCaTH). Progressive evolution at clonal divergence scale was observed while specific driver events were positively selected for clonal sweeps during tumor development. Between-region genetic divergence (BRGD) of tumors were assessed and positively correlated with tumor differentiation. A machine learning algorithm was employed to evaluate clinicopathological and molecular parameters of primary tumors underlying lymph node metastasis. By analyzing clonal lineages and metastatic trajectories across multiple nodal stations, we unraveled a common sequential LNM seeding pattern but with divergent modes of clonal spread.

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This agreement governs the terms on which access will be granted to the genotype data generated by Nanjing Medical University Affiliated Jiangsu Cancer Hospital

DATA ACCESS AGREEMENT 1. You agree to use the Data only for the advancement of medical research, according to the consent obtained from sample donors. 2. You agree to preserve, at all times, the confidentiality of information and Data pertaining to Data Subjects. In particular, You undertake not to use, or attempt to use the Data to compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy. 3. You agree not to attempt to link the data provided under this agreement to other information or archive data available for the data sets provided, even if access to that data has been formally granted to you, or it is freely available without restriction, without specific permission being sought from the relevent access committees. 4. You agree not to transfer or disclose the Data, in whole or part, or any identifiable material derived from the Data, to others, except as necessary for data/safety monitoring or programme management. Should You wish to share the Data with a collaborator out with the same Institution, the third party must make a separate application for access to the Data. 5. You agree to use the data for the approved purpose and project described in your application; use of the data for a new purpose or project will require a new application and approval. 6. You accept that Data will be reissued from time to time, with suitable versioning. If the reissue is at the request of sample donors and/or other ethical scrutiny, You will destroy earlier versions of the Data. 7. You accept that the Consortium, the original data creators, depositors or copyright holders, or the funders of the Data or any part of the Data supplied: a) bear no legal responsibility for the accuracy or comprehensiveness of the Data; and b) accept no liability for indirect, consequential, or incidental, damages or losses arising from use of the Data, or from the unavailability of, or break in access to, the Data for whatever reason. 8. You understand and acknowledge that the Data i

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
Other
Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00004724750 vcf 7.7 MB
EGAF00004724751 vcf 9.2 MB
EGAF00004724752 vcf 3.4 MB
EGAF00004724753 vcf 3.9 MB
EGAF00004724754 vcf 3.8 MB
EGAF00004724755 vcf 3.2 MB
EGAF00004724756 vcf 3.2 MB
EGAF00004724757 vcf 16.5 MB
EGAF00004724758 vcf 3.0 MB
EGAF00004724759 vcf 9.9 MB
EGAF00004724760 vcf 11.6 MB
EGAF00004724761 vcf 8.5 MB
EGAF00004724762 vcf 9.0 MB
EGAF00004724763 vcf 2.6 MB
EGAF00004724764 vcf 19.5 MB
EGAF00004724765 vcf 17.9 MB
EGAF00004724766 vcf 11.3 MB
EGAF00004724767 vcf 8.5 MB
EGAF00004724768 vcf 6.4 MB
EGAF00004724769 vcf 7.1 MB
EGAF00004724770 vcf 9.0 MB
EGAF00004724771 vcf 6.1 MB
EGAF00004724772 vcf 8.6 MB
EGAF00004724773 vcf 8.4 MB
EGAF00004724774 vcf 8.3 MB
EGAF00004724775 vcf 9.2 MB
EGAF00004724776 vcf 9.3 MB
EGAF00004724777 vcf 7.6 MB
EGAF00004724778 vcf 8.4 MB
EGAF00004724779 vcf 7.5 MB
EGAF00004724780 vcf 7.8 MB
EGAF00004724781 vcf 4.0 MB
EGAF00004724782 vcf 2.1 MB
EGAF00004724783 vcf 1.9 MB
EGAF00004724784 vcf 6.5 MB
EGAF00004724785 vcf 5.1 MB
EGAF00004724786 vcf 8.3 MB
EGAF00004724787 vcf 6.3 MB
EGAF00004724788 vcf 5.4 MB
EGAF00004724789 vcf 9.7 MB
EGAF00004724790 vcf 7.8 MB
EGAF00004724791 vcf 6.9 MB
EGAF00004724792 vcf 7.9 MB
EGAF00004724793 vcf 4.7 MB
EGAF00004724794 vcf 9.1 MB
EGAF00004724795 vcf 3.7 MB
EGAF00004724796 vcf 6.7 MB
EGAF00004724797 vcf 4.4 MB
EGAF00004724798 vcf 4.4 MB
EGAF00004724799 vcf 2.3 MB
EGAF00004724800 vcf 5.5 MB
EGAF00004724801 vcf 6.3 MB
EGAF00004724802 vcf 6.3 MB
EGAF00004724803 vcf 5.2 MB
EGAF00004724804 vcf 15.8 MB
EGAF00004724805 vcf 6.1 MB
EGAF00004724806 vcf 5.0 MB
EGAF00004724807 vcf 3.6 MB
EGAF00004724808 vcf 3.6 MB
EGAF00004724809 vcf 4.5 MB
EGAF00004724810 vcf 13.7 MB
EGAF00004724811 vcf 4.6 MB
EGAF00004724812 vcf 4.8 MB
EGAF00004724813 vcf 4.5 MB
EGAF00004724814 vcf 7.6 MB
EGAF00004724815 vcf 3.4 MB
EGAF00004724816 vcf 6.1 MB
EGAF00004724817 vcf 7.4 MB
EGAF00004724818 vcf 7.3 MB
EGAF00004724819 vcf 4.8 MB
EGAF00004724820 vcf 6.8 MB
EGAF00004724821 vcf 3.7 MB
EGAF00004724822 vcf 3.0 MB
EGAF00004724823 vcf 4.1 MB
EGAF00004724824 vcf 5.5 MB
EGAF00004724825 vcf 6.4 MB
EGAF00004724826 vcf 4.9 MB
EGAF00004724827 vcf 5.0 MB
EGAF00004724828 vcf 6.4 MB
EGAF00004724829 vcf 3.2 MB
EGAF00004724830 vcf 5.5 MB
EGAF00004724831 vcf 2.6 MB
EGAF00004724832 vcf 5.7 MB
EGAF00004724833 vcf 7.2 MB
EGAF00004724834 vcf 8.7 MB
EGAF00004724835 vcf 5.9 MB
EGAF00004724836 vcf 8.2 MB
EGAF00004724837 vcf 4.7 MB
EGAF00004724838 vcf 5.9 MB
EGAF00004724839 vcf 6.6 MB
EGAF00004724840 vcf 5.2 MB
EGAF00004724841 vcf 6.9 MB
EGAF00004724842 vcf 6.4 MB
EGAF00004724843 vcf 3.6 MB
EGAF00004724844 vcf 4.7 MB
EGAF00004724845 vcf 4.1 MB
EGAF00004724846 vcf 4.6 MB
EGAF00004724847 vcf 5.5 MB
EGAF00004724848 vcf 7.2 MB
EGAF00004724849 vcf 3.9 MB
EGAF00004724850 vcf 4.8 MB
EGAF00004724851 vcf 6.7 MB
EGAF00004724852 vcf 6.6 MB
EGAF00004724853 vcf 3.4 MB
EGAF00004724854 vcf 6.0 MB
EGAF00004724855 vcf 5.7 MB
EGAF00004724856 vcf 7.4 MB
EGAF00004724857 vcf 5.3 MB
EGAF00004724858 vcf 6.2 MB
EGAF00004724859 vcf 4.9 MB
EGAF00004724860 vcf 1.1 MB
EGAF00004724861 vcf 496.0 kB
EGAF00004724862 vcf 5.7 MB
EGAF00004724863 vcf 901.6 kB
EGAF00004724864 vcf 6.9 MB
EGAF00004724865 vcf 6.1 MB
EGAF00004724866 vcf 5.0 MB
EGAF00004724867 vcf 2.9 MB
EGAF00004724868 vcf 1.8 MB
EGAF00004724869 vcf 5.2 MB
EGAF00004724870 vcf 3.9 MB
EGAF00004724871 vcf 5.0 MB
EGAF00004724872 vcf 2.5 MB
EGAF00004724873 vcf 7.0 MB
EGAF00004724874 vcf 2.5 MB
EGAF00004724875 vcf 4.6 MB
EGAF00004724876 vcf 6.5 MB
EGAF00004724877 vcf 5.7 MB
EGAF00004724878 vcf 4.4 MB
EGAF00004724879 vcf 3.7 MB
EGAF00004724880 vcf 7.1 MB
EGAF00004724881 vcf 6.1 MB
EGAF00004724882 vcf 7.9 MB
EGAF00004724883 vcf 5.5 MB
EGAF00004724884 vcf 8.0 MB
EGAF00004724885 vcf 8.4 MB
EGAF00004724886 vcf 3.8 MB
EGAF00004724887 vcf 4.4 MB
EGAF00004724888 vcf 4.1 MB
EGAF00004724889 vcf 7.9 MB
EGAF00004724890 vcf 2.6 MB
EGAF00004724891 vcf 6.7 MB
EGAF00004724892 vcf 5.1 MB
EGAF00004724893 vcf 3.6 MB
EGAF00004724894 vcf 2.2 MB
EGAF00004724895 vcf 5.4 MB
EGAF00004724896 vcf 6.7 MB
EGAF00004724897 vcf 7.5 MB
EGAF00004724898 vcf 6.5 MB
EGAF00004724899 vcf 4.1 MB
EGAF00004724900 vcf 6.3 MB
EGAF00004724901 vcf 10.6 MB
EGAF00004724902 vcf 4.9 MB
EGAF00004724903 vcf 5.2 MB
EGAF00004724904 vcf 7.0 MB
EGAF00004724905 vcf 3.3 MB
EGAF00004724906 vcf 5.7 MB
EGAF00004724907 vcf 6.0 MB
EGAF00004724908 vcf 15.7 MB
EGAF00004724909 vcf 16.8 MB
EGAF00004724910 vcf 8.0 MB
EGAF00004724911 vcf 8.1 MB
EGAF00004724912 vcf 8.5 MB
EGAF00004724913 vcf 6.8 MB
EGAF00004724914 vcf 6.8 MB
EGAF00004724915 vcf 7.3 MB
EGAF00004724916 vcf 14.9 MB
EGAF00004724917 vcf 15.7 MB
EGAF00004724918 vcf 9.3 MB
EGAF00004724919 vcf 6.8 MB
EGAF00004724920 vcf 6.9 MB
EGAF00004724921 vcf 7.6 MB
EGAF00004724922 vcf 8.1 MB
EGAF00004724923 vcf 4.2 MB
EGAF00005211623 1620408371920 1.9 kB
EGAF00005211624 1620408371920 1.7 kB
EGAF00005211625 1620408371920 1.4 kB
EGAF00005211626 1620408371920 2.0 kB
EGAF00005211627 1620408371920 1.8 kB
EGAF00005211628 1620408371920 1.5 kB
EGAF00005211629 1620408371920 2.0 kB
EGAF00005211630 1620408371920 1.7 kB
EGAF00005211631 1620408371920 1.7 kB
EGAF00005211632 1620408371920 1.6 kB
EGAF00005211633 1620408371920 1.6 kB
EGAF00005211634 1620408371920 1.5 kB
EGAF00005211635 1620408371920 1.7 kB
EGAF00005211636 1620408371920 1.6 kB
EGAF00005211637 1620408371920 1.6 kB
EGAF00005211638 1620408371920 1.8 kB
EGAF00005211639 1620408371920 1.6 kB
EGAF00005211640 1620408371920 1.8 kB
EGAF00005211641 1620408371920 1.6 kB
EGAF00005211642 1620408371920 1.6 kB
EGAF00005211643 1620408371920 1.7 kB
EGAF00005211644 1620408371920 1.7 kB
EGAF00005211645 1620408371920 1.9 kB
EGAF00005211646 1620408371920 1.6 kB
EGAF00005211647 1620408371920 1.7 kB
EGAF00005211648 1620408371920 1.8 kB
EGAF00005211649 1620408371920 1.6 kB
EGAF00005211650 1620408371920 1.9 kB
EGAF00005211651 1620408371920 1.9 kB
EGAF00005211652 1620408371920 1.6 kB
EGAF00005211653 1620408371920 1.7 kB
EGAF00005211654 1620408371920 1.6 kB
EGAF00005211655 1620408371920 2.0 kB
EGAF00005211656 1620408371920 1.7 kB
EGAF00005211657 1620408371920 1.5 kB
EGAF00005211658 1620408371920 1.7 kB
EGAF00005211659 1620408371920 1.7 kB
EGAF00005211660 1620408371920 1.5 kB
EGAF00005211661 1620408371920 1.6 kB
EGAF00005211662 1620408371920 1.5 kB
EGAF00005211663 1620408371920 2.0 kB
EGAF00005211664 1620408371920 2.0 kB
EGAF00005211665 1620408498208 1.8 kB
EGAF00005211666 1620408498208 1.6 kB
EGAF00005211667 1620408498208 1.5 kB
EGAF00005211668 1620408498208 1.5 kB
EGAF00005211669 1620408498208 1.9 kB
EGAF00005211670 1620408498208 1.6 kB
EGAF00005211671 1620408498208 1.7 kB
EGAF00005211672 1620408498208 1.7 kB
EGAF00005211673 1620408498208 1.5 kB
EGAF00005211674 1620408498208 1.5 kB
EGAF00005211675 1620408498208 1.7 kB
EGAF00005211676 1620408498208 1.8 kB
EGAF00005211677 1620408498208 1.4 kB
EGAF00005211678 1620408498208 1.4 kB
EGAF00005211679 1620408498208 2.1 kB
EGAF00005211680 1620408498208 1.6 kB
EGAF00005211681 1620408498208 1.5 kB
EGAF00005211682 1620408498208 1.5 kB
EGAF00005211683 1620408498208 1.5 kB
EGAF00005211684 1620408498208 1.6 kB
EGAF00005211685 1620408498208 1.7 kB
EGAF00005211686 1620408498208 1.9 kB
EGAF00005211687 1620408498208 1.7 kB
EGAF00005211688 1620408498208 1.5 kB
EGAF00005211689 1620408498208 1.5 kB
EGAF00005211690 1620408498208 1.5 kB
EGAF00005211691 1620408498208 2.1 kB
EGAF00005211692 1620408498208 2.1 kB
EGAF00005211693 1620408498208 1.8 kB
EGAF00005211694 1620408498208 1.8 kB
EGAF00005211695 1620408498208 1.7 kB
EGAF00005211696 1620408498208 1.7 kB
EGAF00005211697 1620408498208 1.6 kB
EGAF00005211698 1620408498208 1.7 kB
EGAF00005211699 1620408498208 1.5 kB
EGAF00005211700 1620408498208 1.7 kB
EGAF00005211701 1620408498208 1.7 kB
EGAF00005211702 1620408498208 1.6 kB
EGAF00005211703 1620408498208 2.0 kB
EGAF00005211704 1620408498208 1.6 kB
EGAF00005211705 1620408498208 1.9 kB
EGAF00005211706 1620408498208 1.5 kB
EGAF00005211707 1620408498208 1.7 kB
EGAF00005211708 1620408498208 1.7 kB
EGAF00005211709 1620408498208 2.8 kB
EGAF00005211710 1620408498208 1.6 kB
EGAF00005211711 1620408498208 1.5 kB
EGAF00005211712 1620408498208 1.5 kB
EGAF00005211713 1620408498208 1.7 kB
EGAF00005211714 1620408498208 1.8 kB
EGAF00005211715 1620408498208 1.7 kB
EGAF00005211716 1620408498208 2.0 kB
EGAF00005211717 1620408498208 1.7 kB
EGAF00005211718 1620408498208 1.7 kB
EGAF00005211719 1620408498208 1.6 kB
EGAF00005211720 1620408498208 1.9 kB
EGAF00005211721 1620408498208 2.0 kB
EGAF00005211722 1620408498208 3.5 kB
EGAF00005211723 1620408498208 2.0 kB
EGAF00005211724 1620408498208 1.5 kB
EGAF00005211725 1620408498208 1.7 kB
EGAF00005211726 1620408498208 1.9 kB
EGAF00005211727 1620408498208 1.6 kB
EGAF00005211728 1620408498208 1.7 kB
EGAF00005211729 1620408498208 2.0 kB
EGAF00005211730 1620408498208 2.1 kB
EGAF00005211731 1620408498208 1.7 kB
EGAF00005211732 1620408498208 1.7 kB
EGAF00005211733 1620408498208 1.7 kB
EGAF00005211734 1620408498208 1.7 kB
EGAF00005211735 1620408498208 3.4 kB
EGAF00005211736 1620408498208 1.6 kB
EGAF00005211737 1620408498208 1.5 kB
EGAF00005211738 1620408498208 1.6 kB
EGAF00005211739 1620408498208 2.0 kB
EGAF00005211740 1620408498208 1.7 kB
EGAF00005211741 1620408498208 1.6 kB
EGAF00005211742 1620408498208 1.5 kB
EGAF00005211743 1620408498208 1.8 kB
EGAF00005211744 1620408498208 1.7 kB
EGAF00005211745 1620408498208 2.3 kB
EGAF00005211746 1620408498208 1.9 kB
EGAF00005211747 1620408552427 1.5 kB
EGAF00005211748 1620408552427 1.6 kB
EGAF00005211749 1620408552427 1.9 kB
EGAF00005211750 1620408552427 2.0 kB
EGAF00005211751 1620408552427 1.9 kB
EGAF00005211752 1620408552427 1.7 kB
EGAF00005211753 1620408552427 1.6 kB
EGAF00005211754 1620408552427 1.8 kB
EGAF00005211755 1620408552427 2.1 kB
EGAF00005211756 1620408552427 1.5 kB
EGAF00005211757 1620408552427 1.5 kB
EGAF00005211758 1620408552427 1.5 kB
EGAF00005211759 1620408552427 1.7 kB
EGAF00005211760 1620408552427 1.8 kB
EGAF00005211761 1620408552427 1.7 kB
EGAF00005211762 1620408552427 2.4 kB
EGAF00005211763 1620408552427 2.0 kB
EGAF00005211764 1620408552427 1.8 kB
EGAF00005211765 1620408552427 1.9 kB
EGAF00005211766 1620408552427 1.4 kB
EGAF00005211767 1620408552427 1.6 kB
EGAF00005211768 1620408552427 1.7 kB
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EGAF00005211770 1620408552427 1.6 kB
EGAF00005211771 1620408552427 1.7 kB
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EGAF00005211777 1620408552427 2.1 kB
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EGAF00005211787 1620408552427 2.4 kB
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EGAF00005211869 1620408701056 2.3 kB
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762 Files (1.1 GB)