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Longitudinal Single-Cell Profiling in Refractory Mantle Cell Lymphoma

we performed sequential scRNA-seq of 21 specimens (discovery cohort) collected at baseline, during treatment, and/or at disease remission/progression from 3 ibrutinib-responsive (R) patients (Pt-V, C and D) and 2 non-responsive (NR) patients (Pt-B and E). In addition, the PBMC samples from two healthy donors (N1 and N2) were included as the normal controls.

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The Wang Laboratory research program aims to elucidate the mechanisms underlying therapeutic resistance in B-cell lymphoma and to translate these findings to the clinic to improve patient outcomes. The research group has utilized genomics and molecular analysis, patient-derived xenograft (PDX) mouse models and state-of-the-art molecular tools to understand the cellular mechanisms responsible for therapeutic resistance and disease progression in mantle cell lymphoma (MCL), with rapid expansion into diffuse large B-cell lymphoma (DLBCL).

For each dataset that requires controlled access, there is a corresponding Data Access Committee (DAC) who determine access permissions. Access to actual data files is not managed by the EGA. If you need to request access to this data set, please contact

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001005019 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00004996313 bam 9.4 GB
EGAF00004996314 bam 11.0 GB
EGAF00004996315 bam 10.2 GB
EGAF00004996316 bam 10.3 GB
EGAF00004996317 fastq.gz 362.1 MB
EGAF00004996318 fastq.gz 1.3 GB
EGAF00004996319 fastq.gz 402.1 MB
EGAF00004996320 fastq.gz 1.4 GB
EGAF00004996321 fastq.gz 402.1 MB
EGAF00004996322 fastq.gz 1.4 GB
EGAF00004996323 fastq.gz 563.8 MB
EGAF00004996324 fastq.gz 2.1 GB
EGAF00004996331 fastq.gz 510.0 MB
EGAF00004996332 fastq.gz 1.8 GB
EGAF00004996333 fastq.gz 564.4 MB
EGAF00004996334 fastq.gz 2.0 GB
EGAF00004996335 fastq.gz 566.7 MB
EGAF00004996336 fastq.gz 2.0 GB
EGAF00004996337 fastq.gz 487.3 MB
EGAF00004996338 fastq.gz 1.8 GB
EGAF00004996339 fastq.gz 625.7 MB
EGAF00004996340 fastq.gz 2.3 GB
EGAF00004996341 fastq.gz 624.1 MB
EGAF00004996342 fastq.gz 2.3 GB
EGAF00004996343 fastq.gz 558.1 MB
EGAF00004996344 fastq.gz 2.0 GB
EGAF00004996345 fastq.gz 542.0 MB
EGAF00004996346 fastq.gz 2.0 GB
EGAF00004996347 fastq.gz 553.5 MB
EGAF00004996348 fastq.gz 2.0 GB
EGAF00004996349 fastq.gz 472.5 MB
EGAF00004996350 fastq.gz 1.8 GB
EGAF00004996351 fastq.gz 525.6 MB
EGAF00004996352 fastq.gz 1.9 GB
EGAF00004996353 fastq.gz 2.7 GB
EGAF00004996354 fastq.gz 12.5 GB
EGAF00004996355 fastq.gz 537.4 MB
EGAF00004996356 fastq.gz 2.0 GB
EGAF00004996357 fastq.gz 2.5 GB
EGAF00004996358 fastq.gz 11.9 GB
EGAF00004996359 fastq.gz 827.9 MB
EGAF00004996360 fastq.gz 3.1 GB
EGAF00004996361 fastq.gz 945.2 MB
EGAF00004996362 fastq.gz 3.6 GB
EGAF00004996363 fastq.gz 921.9 MB
EGAF00004996364 fastq.gz 3.5 GB
EGAF00004996365 fastq.gz 938.5 MB
EGAF00004996366 fastq.gz 3.5 GB
EGAF00004996367 fastq.gz 526.0 MB
EGAF00004996368 fastq.gz 1.9 GB
EGAF00004996369 fastq.gz 602.6 MB
EGAF00004996370 fastq.gz 2.2 GB
EGAF00004996371 fastq.gz 586.7 MB
EGAF00004996372 fastq.gz 2.2 GB
EGAF00004996373 fastq.gz 598.5 MB
EGAF00004996374 fastq.gz 2.2 GB
EGAF00004996375 fastq.gz 2.5 GB
EGAF00004996376 fastq.gz 11.6 GB
EGAF00004996377 fastq.gz 558.4 MB
EGAF00004996378 fastq.gz 2.0 GB
EGAF00004996379 fastq.gz 621.7 MB
EGAF00004996380 fastq.gz 2.2 GB
EGAF00004996381 fastq.gz 584.7 MB
EGAF00004996382 fastq.gz 2.1 GB
EGAF00004996383 fastq.gz 587.4 MB
EGAF00004996384 fastq.gz 2.5 GB
EGAF00004996385 fastq.gz 604.8 MB
EGAF00004996386 fastq.gz 2.6 GB
EGAF00004996387 fastq.gz 592.7 MB
EGAF00004996388 fastq.gz 2.5 GB
EGAF00004996389 fastq.gz 655.9 MB
EGAF00004996390 fastq.gz 2.6 GB
EGAF00004996391 fastq.gz 537.6 MB
EGAF00004996392 fastq.gz 2.3 GB
EGAF00004996393 fastq.gz 553.5 MB
EGAF00004996394 fastq.gz 2.3 GB
EGAF00004996395 fastq.gz 542.5 MB
EGAF00004996396 fastq.gz 2.3 GB
EGAF00004996397 fastq.gz 600.2 MB
EGAF00004996398 fastq.gz 2.4 GB
EGAF00004996399 fastq.gz 590.5 MB
EGAF00004996400 fastq.gz 2.5 GB
EGAF00004996401 fastq.gz 657.9 MB
EGAF00004996402 fastq.gz 2.6 GB
EGAF00004996403 fastq.gz 595.5 MB
EGAF00004996404 fastq.gz 2.5 GB
EGAF00004996405 fastq.gz 598.7 MB
EGAF00004996406 fastq.gz 2.5 GB
EGAF00004996407 fastq.gz 833.4 MB
EGAF00004996517 fastq.gz 621.0 MB
EGAF00004996518 fastq.gz 2.2 GB
EGAF00004996519 fastq.gz 630.0 MB
EGAF00004996520 fastq.gz 2.2 GB
EGAF00004996521 fastq.gz 659.2 MB
EGAF00004996522 fastq.gz 2.3 GB
EGAF00004996523 fastq.gz 651.5 MB
EGAF00004996524 fastq.gz 2.3 GB
EGAF00004996525 fastq.gz 651.0 MB
EGAF00004996526 fastq.gz 2.3 GB
EGAF00004996527 fastq.gz 607.4 MB
EGAF00004996528 fastq.gz 2.6 GB
EGAF00004996529 fastq.gz 2.6 GB
EGAF00004996530 fastq.gz 12.6 GB
EGAF00004996531 fastq.gz 2.5 GB
EGAF00004996532 fastq.gz 11.8 GB
EGAF00004996533 fastq.gz 586.3 MB
EGAF00004996534 fastq.gz 2.2 GB
EGAF00004996535 fastq.gz 585.2 MB
EGAF00004996536 fastq.gz 2.2 GB
EGAF00004996606 fastq.gz 514.3 MB
EGAF00004996607 fastq.gz 1.9 GB
EGAF00004996608 fastq.gz 585.5 MB
EGAF00004996609 fastq.gz 2.2 GB
EGAF00004996610 fastq.gz 515.4 MB
EGAF00004996611 fastq.gz 1.9 GB
EGAF00004996612 fastq.gz 609.3 MB
EGAF00004996613 fastq.gz 2.2 GB
EGAF00004996614 fastq.gz 533.2 MB
EGAF00004996615 fastq.gz 1.9 GB
EGAF00004996616 fastq.gz 663.0 MB
EGAF00004996617 fastq.gz 2.4 GB
EGAF00004996618 fastq.gz 657.6 MB
EGAF00004996619 fastq.gz 2.4 GB
EGAF00004996620 fastq.gz 662.1 MB
EGAF00004996621 fastq.gz 2.4 GB
EGAF00004996622 fastq.gz 580.2 MB
EGAF00004996623 fastq.gz 2.1 GB
EGAF00004996624 fastq.gz 2.6 GB
EGAF00004996625 fastq.gz 12.8 GB
EGAF00004996626 fastq.gz 573.3 MB
EGAF00004996627 fastq.gz 2.0 GB
EGAF00004996628 fastq.gz 541.2 MB
EGAF00004996629 fastq.gz 2.0 GB
EGAF00004996630 fastq.gz 634.0 MB
EGAF00004996631 fastq.gz 2.3 GB
EGAF00004996632 fastq.gz 406.8 MB
EGAF00004996633 fastq.gz 1.4 GB
EGAF00005028363 fastq.gz 16.4 GB
EGAF00005028364 fastq.gz 16.8 GB
EGAF00005029055 fastq.gz 15.4 GB
EGAF00005029056 fastq.gz 15.9 GB
EGAF00005029061 fastq.gz 15.0 GB
EGAF00005029062 fastq.gz 15.4 GB
EGAF00005029063 fastq.gz 14.9 GB
EGAF00005029064 fastq.gz 15.3 GB
EGAF00005029209 fastq.gz 15.7 GB
EGAF00005029210 fastq.gz 16.2 GB
EGAF00005029223 fastq.gz 16.3 GB
EGAF00005029224 fastq.gz 16.7 GB
EGAF00005029225 fastq.gz 16.0 GB
EGAF00005029226 fastq.gz 16.4 GB
EGAF00005029227 fastq.gz 14.8 GB
EGAF00005029228 fastq.gz 15.4 GB
153 Files (552.4 GB)