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INSPIRE Whole Exome Sequencing - Tumors

INSPIRE whole exome sequencing of tumors updated

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Access to data generated by UHN is made available by completing the data access agreement for review by the data access committee and will be granted to qualified investigators for appropriate use.

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom the Data Access Committee (DAC) grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: The Principal Investigator and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. University Health Network: The University Health Network (UHN) is the largest clinical and research hospital in Canada. UHN is affiliated with the University of Toronto and is a member of the Toronto Academic Health Science Network. 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify the DAC within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify the DAC prior to any significant changes to the protocol for the Project. 14. The User Institution will notify the DAC as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. The DAC may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of the province of Ontario and PHIPA. Agreed for User Institution Signature: Name: Title: Date: Principal Investigator I confirm that I have read and understood this Agreement. Signature: Name: Title: Date: Agreed for The Data Access Committee Signature: Name: Title: Date: APPENDIX I – DATASET DETAILS APPENDIX II ––PROJECT DETAILS APPENDIX III –– PUBLICATION POLICY

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001003280 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00004835148 bam 28.5 GB
EGAF00004835149 bam 26.5 GB
EGAF00004835150 bam 26.1 GB
EGAF00004835151 bam 26.1 GB
EGAF00004835152 bam 27.2 GB
EGAF00004835153 bam 21.7 GB
EGAF00004835154 bam 29.2 GB
EGAF00004835155 bam 26.4 GB
EGAF00004835156 bam 27.3 GB
EGAF00004835157 bam 25.3 GB
EGAF00004835158 bam 34.0 GB
EGAF00004835159 bam 28.9 GB
EGAF00004835160 bam 35.1 GB
EGAF00004835161 bam 31.8 GB
EGAF00004835162 bam 33.9 GB
EGAF00004835163 bam 42.9 GB
EGAF00004835164 bam 32.4 GB
EGAF00004835165 bam 35.7 GB
EGAF00004835166 bam 34.9 GB
EGAF00004835167 bam 31.1 GB
EGAF00004835168 bam 31.7 GB
EGAF00004835169 bam 38.4 GB
EGAF00004835170 bam 26.3 GB
EGAF00004835171 bam 19.7 GB
EGAF00004835172 bam 21.6 GB
EGAF00004835173 bam 17.5 GB
EGAF00004835174 bam 28.8 GB
EGAF00004835175 bam 27.0 GB
EGAF00004835176 bam 27.7 GB
EGAF00004835177 bam 27.6 GB
EGAF00004835178 bam 16.7 GB
EGAF00004835179 bam 28.2 GB
EGAF00004835180 bam 22.0 GB
EGAF00004835181 bam 28.5 GB
EGAF00004835182 bam 23.5 GB
EGAF00004835183 bam 30.6 GB
EGAF00004835184 bam 22.9 GB
EGAF00004835185 bam 20.6 GB
EGAF00004835186 bam 17.8 GB
EGAF00004835187 bam 21.0 GB
EGAF00004835188 bam 24.8 GB
EGAF00004835189 bam 25.0 GB
EGAF00004835190 bam 26.3 GB
EGAF00004835191 bam 26.1 GB
EGAF00004835192 bam 28.8 GB
EGAF00004835193 bam 31.6 GB
EGAF00004835194 bam 18.2 GB
EGAF00004835195 bam 35.7 GB
EGAF00004835196 bam 31.2 GB
EGAF00004835197 bam 30.8 GB
EGAF00004835198 bam 30.3 GB
EGAF00004835199 bam 21.3 GB
EGAF00004835200 bam 21.8 GB
EGAF00004835201 bam 22.8 GB
EGAF00004835202 bam 24.3 GB
EGAF00004835203 bam 26.1 GB
EGAF00004835204 bam 27.2 GB
EGAF00004835205 bam 22.3 GB
EGAF00004835206 bam 24.7 GB
EGAF00004835207 bam 26.1 GB
EGAF00004835208 bam 18.7 GB
EGAF00004835209 bam 20.1 GB
EGAF00004835210 bam 25.5 GB
EGAF00004835211 bam 20.4 GB
EGAF00004835212 bam 26.8 GB
EGAF00004835213 bam 26.5 GB
EGAF00004835214 bam 27.8 GB
EGAF00004835215 bam 29.0 GB
EGAF00004835216 bam 28.7 GB
EGAF00004835217 bam 27.5 GB
EGAF00004835218 bam 33.6 GB
EGAF00004835219 bam 23.0 GB
EGAF00004835220 bam 22.1 GB
EGAF00004835221 bam 23.0 GB
EGAF00004835222 bam 13.4 GB
EGAF00004835223 bam 20.4 GB
EGAF00004835224 bam 31.9 GB
EGAF00004835225 bam 29.1 GB
EGAF00004835226 bam 21.9 GB
EGAF00004835227 bam 23.0 GB
EGAF00004835228 bam 24.9 GB
EGAF00004835229 bam 24.3 GB
EGAF00004835230 bam 22.3 GB
EGAF00004835231 bam 25.9 GB
EGAF00004835232 bam 26.1 GB
EGAF00004835233 bam 22.1 GB
EGAF00004835234 bam 21.7 GB
EGAF00004835235 bam 30.0 GB
EGAF00004835236 bam 33.1 GB
EGAF00004835237 bam 25.1 GB
EGAF00004835238 bam 22.9 GB
EGAF00004835239 bam 24.0 GB
EGAF00004835240 bam 19.7 GB
EGAF00004835241 bam 27.1 GB
EGAF00004835242 bam 28.2 GB
EGAF00004835243 bam 22.8 GB
96 Files (2.5 TB)