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Rucaparib in patients presenting a metastatic breast cancer

Whole genome sequencing was performed on 24 patients (tumor DNA paired to constitutional DNA). WGS libraries were subjected to paired-end (2 x 100 bp) sequencing on NovaSeq (Illumina). The 96 files are in FASTQ format.

Request Access

This DAC will enable you to have access to the RUBY study data

Preamble UNICANCER set up a Data Access Committee (DAC) to process requests for access to the “Rucaparib in patients presenting a metastatic breast cancer with Homologous Recombination Deficiency, without germline BRCA1/2 mutation, pronostic value of high LOH genomic score and predictive value of HRDetect” data, from now on named RUBY data. Article I. Data Access Committee Article I.1 Composition RUBY study’s DAC is composed of Anne Patsouris, Marta Jimenez and Alicia Tran Dien. Article I.1 Missions RUBY Study’s DAC is responsible for authorizing access to the data. Article II. Request for access to data Article II.1 Composition of the application file The data access request requires on demand: - A summary of the study (synopsis template) : it can be very light. We just need to know the general question that is going to be addressed; - The CNIL declaration : we can take care of the submission part to the CNIL, once we receive it; - The standard contractual clauses signed if your country is located outside of the European Community (check if your country is concerned : https://www.cnil.fr/en/data-protection-around-the-world) - The opinion issued by an Institution Review Board / or ethical committee that evaluated the project and the composition of the committee(s), if any; - The confidentiality form - The documentation necessary to demonstrate compliance with all its data protection and security obligations (a security charter); - This data access policy signed Article II.2 Application procedures The request for access to the data is free. It is done by mail to the following addresses Anne.Patsouris@ico.unicancer.fr m-jimenez@unicancer.fr ALICIA.TRAN-DIEN@gustaveroussy.fr Article II.3. Examination of applications Following the filing of the file with the DAC, the latter: - verify its good orientation and completeness. Otherwise, the DAC will contact the requester for further information; - instruct the request for access to the data within one month after receiving the complete file. This time is given as an indication. Article III. Conditions of use of the data The applicants undertake to respect all the following measures and to have them respected by their staff as well as any other person(s) assisting them with the use of the data: - To collect only data adequate, relevant, limited and strictly necessary to the specific treatment that it with these data; - Do not use the data to which they can access for purposes other than those indicated in the application file; - Disclose this data only to persons duly authorized by reason of their duties and who have been indicated in the data access request file; - Do not make any copy of this data except that it is necessary for the execution of their research; - Respect the patient decision to withdraw his/her data from the project - Take all necessary measures to avoid misuse or fraudulent use of this data; - Ensure that only secure means of communication will be used to transfer this data; - At the end of the research project, to fully restore the data, computer files and any information related to these data. When this task falls within its remit, the applicants undertake to ensure that the persons from whom they collect and / or use the data have been previously informed of the specific treatment that they are carrying out with their data. Article IV. Notification of data breach As soon as it becomes aware of this and within a maximum of seventy-two (72) hours, the requester notifies the DAC of any data breach. The requester provides to the DAC at the time of notification of the incident, or if this is not reasonably possible as soon as possible after the notification of the data breach, the following information regarding their violation: 1) The nature of the data breach; 2) The estimated number of people involved; 3) Categories of the person(s) involved; 4) The categories of Data concerned; 5) The estimated number of Data violated; Measures taken to remedy the data breach, including, measures to limit adverse effects and potential risks. The applicants shall as far as possible assist the DAC in reporting the data breach to the relevant control authorization and / or to the person(s) involved in the data breach. Article V. Data destruction At the end of the research, the applicants undertake, after having made sure of the terms relating to reversibility: - Destroy all data - Return all data to the DAC - Return the data to the subcontractor designated by the DAC The return must be accompanied by the destruction of all data (including copies) in the information systems of the applicant and their collaborators.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
Whole Genome Sequencing

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00004724652 fastq.gz 19.7 GB
EGAF00004724653 fastq.gz 20.5 GB
EGAF00004724654 fastq.gz 17.9 GB
EGAF00004724655 fastq.gz 18.5 GB
EGAF00004724656 fastq.gz 20.6 GB
EGAF00004724657 fastq.gz 21.5 GB
EGAF00004724658 fastq.gz 28.3 GB
EGAF00004724659 fastq.gz 30.0 GB
EGAF00004724660 fastq.gz 24.4 GB
EGAF00004724661 fastq.gz 25.5 GB
EGAF00004724662 fastq.gz 11.2 GB
EGAF00004724663 fastq.gz 11.9 GB
EGAF00004724664 fastq.gz 18.8 GB
EGAF00004724665 fastq.gz 19.5 GB
EGAF00004724666 fastq.gz 28.9 GB
EGAF00004724667 fastq.gz 30.5 GB
EGAF00004724668 fastq.gz 8.9 GB
EGAF00004724669 fastq.gz 9.3 GB
EGAF00004724670 fastq.gz 16.7 GB
EGAF00004724671 fastq.gz 17.4 GB
EGAF00004724672 fastq.gz 17.8 GB
EGAF00004724673 fastq.gz 18.4 GB
EGAF00004724674 fastq.gz 40.1 GB
EGAF00004724675 fastq.gz 41.9 GB
EGAF00004724676 fastq.gz 15.8 GB
EGAF00004724677 fastq.gz 16.5 GB
EGAF00004724678 fastq.gz 12.9 GB
EGAF00004724679 fastq.gz 13.3 GB
EGAF00004724680 fastq.gz 8.2 GB
EGAF00004724681 fastq.gz 8.6 GB
EGAF00004724682 fastq.gz 17.6 GB
EGAF00004724683 fastq.gz 18.2 GB
EGAF00004724684 fastq.gz 83.0 GB
EGAF00004724685 fastq.gz 92.9 GB
EGAF00004724686 fastq.gz 36.3 GB
EGAF00004724687 fastq.gz 41.2 GB
EGAF00004724688 fastq.gz 24.2 GB
EGAF00004724689 fastq.gz 25.0 GB
EGAF00004724690 fastq.gz 32.6 GB
EGAF00004724691 fastq.gz 33.9 GB
EGAF00004724692 fastq.gz 22.5 GB
EGAF00004724693 fastq.gz 23.4 GB
EGAF00004724694 fastq.gz 74.4 GB
EGAF00004724695 fastq.gz 80.1 GB
EGAF00004724696 fastq.gz 34.9 GB
EGAF00004724697 fastq.gz 36.7 GB
EGAF00004724698 fastq.gz 20.3 GB
EGAF00004724699 fastq.gz 21.3 GB
EGAF00004724700 fastq.gz 10.6 GB
EGAF00004724701 fastq.gz 11.5 GB
EGAF00004724702 fastq.gz 34.1 GB
EGAF00004724703 fastq.gz 35.8 GB
EGAF00004724704 fastq.gz 91.0 GB
EGAF00004724705 fastq.gz 98.3 GB
EGAF00004724706 fastq.gz 27.3 GB
EGAF00004724707 fastq.gz 28.9 GB
EGAF00004724708 fastq.gz 25.6 GB
EGAF00004724709 fastq.gz 26.4 GB
EGAF00004724710 fastq.gz 20.7 GB
EGAF00004724711 fastq.gz 21.5 GB
EGAF00004724712 fastq.gz 20.4 GB
EGAF00004724713 fastq.gz 21.1 GB
EGAF00004724714 fastq.gz 60.4 GB
EGAF00004724715 fastq.gz 63.2 GB
EGAF00004724716 fastq.gz 22.5 GB
EGAF00004724717 fastq.gz 23.5 GB
EGAF00004724718 fastq.gz 13.9 GB
EGAF00004724719 fastq.gz 14.5 GB
EGAF00004724720 fastq.gz 19.8 GB
EGAF00004724721 fastq.gz 20.6 GB
EGAF00004724722 fastq.gz 5.5 GB
EGAF00004724723 fastq.gz 5.7 GB
EGAF00004724724 fastq.gz 20.5 GB
EGAF00004724725 fastq.gz 21.5 GB
EGAF00004724726 fastq.gz 7.1 GB
EGAF00004724727 fastq.gz 7.5 GB
EGAF00004724728 fastq.gz 18.5 GB
EGAF00004724729 fastq.gz 19.2 GB
EGAF00004724730 fastq.gz 27.5 GB
EGAF00004724731 fastq.gz 28.5 GB
EGAF00004724732 fastq.gz 12.2 GB
EGAF00004724733 fastq.gz 12.7 GB
EGAF00004724734 fastq.gz 20.3 GB
EGAF00004724735 fastq.gz 21.0 GB
EGAF00004724736 fastq.gz 37.0 GB
EGAF00004724737 fastq.gz 39.6 GB
EGAF00004724738 fastq.gz 68.0 GB
EGAF00004724739 fastq.gz 72.1 GB
EGAF00004724740 fastq.gz 29.5 GB
EGAF00004724741 fastq.gz 30.9 GB
EGAF00004724742 fastq.gz 112.4 GB
EGAF00004724743 fastq.gz 119.2 GB
EGAF00004724744 fastq.gz 9.2 GB
EGAF00004724745 fastq.gz 9.8 GB
EGAF00004724746 fastq.gz 19.0 GB
EGAF00004724747 fastq.gz 19.7 GB
96 Files (2.8 TB)