Analysis of the Patient derived cells that model the intratumoral heterogeneity of hypermutated IDH1 mutant glioma

Dataset contains paired-end Whole Exome sequencing data from 2 glioma patients (1 oligodendroglioma and 1 astrocytoma) , derived cultured cells, and derived murine xenografts.

28 samples
DAC: EGAC00001000153

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Glioma Genomics Committee Agreements

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID	Study Title	Study Type
	Lindsey E. Jones et al. Patient-derived cells from recurrent tumors that model the evolution of IDH-mutant glioma. Neuro-Oncology Advances, 2020. We established robust, versatile, and well-characterized Patient Derived Cells (PDC) of an IDH1-mutant astrocytoma and an IDH1-mutant oligodendroglioma that represents defined evolutionary stages of chemotherapy-induced hypermutation. The PDCs retain tumor subtype defining features over time as well as classic hallmarks of cancer, including anchorage independent growth and cell immortality. The integrated phylogenies composed of PDCs,single-cell-derived PDCs, patient-derived xenografts, and corresponding spatiotemporal tumor tissue samples also provide new insight into the clonality, evolutionary pattern, and immense mutational load of hypermutated IDH mutant gliomas.	Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID	File Type	Size
EGAF00004200202	bam	13.8 GB
EGAF00004200203	bam	13.6 GB
EGAF00004200204	bam	14.3 GB
EGAF00004200205	bam	14.0 GB
EGAF00004200206	bam	17.1 GB
EGAF00004200207	bam	15.8 GB
EGAF00004200208	bam	17.1 GB
EGAF00004200209	bam	16.4 GB
EGAF00004200210	bam	14.5 GB
EGAF00004200211	bam	13.9 GB
EGAF00004200212	bam	11.9 GB
EGAF00004200213	bam	10.8 GB
EGAF00004200214	bam	14.6 GB
EGAF00004200215	bam	22.2 GB
EGAF00004200216	bam	19.4 GB
EGAF00004200217	bam	20.2 GB
EGAF00004200218	bam	20.7 GB
EGAF00004200219	bam	21.0 GB
EGAF00004200220	bam	21.2 GB
EGAF00004200221	bam	10.2 GB
EGAF00004200222	bam	10.1 GB
EGAF00004200223	bam	9.1 GB
EGAF00004200224	bam	9.1 GB
EGAF00004200225	bam	9.7 GB
EGAF00004200226	bam	10.9 GB
EGAF00004200227	bam	11.4 GB
EGAF00004200228	bam	11.6 GB
EGAF00004200229	bam	12.4 GB
28 Files (406.9 GB)