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Peripheral immunoprofiling of stratifies COVID-19 patients based on disease-specific neutrophil signatures

The SARS-CoV-2 pandemic has led to increasing numbers of COVID-19 patients all over the world. Aetiopathologies range from no symptoms, mild flu-like to severe cases succumbing to respiratory failure. Reports on a dysregulated immune system in the severe cases, showing similarities to cytokine release syndrome, calls for better characterization and understanding of the changes in the immune system as well as their variance across COVID-19 patients in order to be able to design according to host-directed therapies. Here, we profiled blood transcriptomes of 39 COVID-19 patients and 10 control donors. Enriched granulocyte signatures in whole blood samples were verified in granulocyte samples from 49 COVID-19 patients in a second cohort.

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whole blood COVID-19 data access policy

Access to data generated is made available by completing the data access agreement for review by the data access committee and will be granted exclusively to qualified investigators for appropriate use.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00004150656 fastq.gz 3.0 GB
EGAF00004150657 fastq.gz 3.2 GB
EGAF00004150658 fastq.gz 3.4 GB
EGAF00004150659 fastq.gz 3.5 GB
EGAF00004150660 fastq.gz 2.4 GB
EGAF00004150661 fastq.gz 2.5 GB
EGAF00004150662 fastq.gz 2.4 GB
EGAF00004150663 fastq.gz 2.6 GB
EGAF00004150664 fastq.gz 2.3 GB
EGAF00004150665 fastq.gz 2.5 GB
EGAF00004150666 fastq.gz 5.3 GB
EGAF00004150667 fastq.gz 5.5 GB
EGAF00004150668 fastq.gz 2.7 GB
EGAF00004150669 fastq.gz 2.8 GB
EGAF00004150670 fastq.gz 2.4 GB
EGAF00004150671 fastq.gz 2.5 GB
EGAF00004150672 fastq.gz 2.8 GB
EGAF00004150673 fastq.gz 3.1 GB
EGAF00004150674 fastq.gz 3.3 GB
EGAF00004150675 fastq.gz 3.6 GB
EGAF00004150676 fastq.gz 3.4 GB
EGAF00004150677 fastq.gz 3.6 GB
EGAF00004150678 fastq.gz 4.9 GB
EGAF00004150679 fastq.gz 5.1 GB
EGAF00004150680 fastq.gz 2.2 GB
EGAF00004150681 fastq.gz 2.2 GB
EGAF00004150682 fastq.gz 2.0 GB
EGAF00004150683 fastq.gz 2.2 GB
EGAF00004150684 fastq.gz 3.3 GB
EGAF00004150685 fastq.gz 3.8 GB
EGAF00004150686 fastq.gz 3.0 GB
EGAF00004150687 fastq.gz 3.1 GB
EGAF00004150688 fastq.gz 2.2 GB
EGAF00004150689 fastq.gz 2.4 GB
EGAF00004150690 fastq.gz 2.5 GB
EGAF00004150691 fastq.gz 2.8 GB
EGAF00004150692 fastq.gz 1.4 GB
EGAF00004150693 fastq.gz 1.6 GB
EGAF00004150694 fastq.gz 3.3 GB
EGAF00004150695 fastq.gz 3.5 GB
EGAF00004150696 fastq.gz 2.5 GB
EGAF00004150697 fastq.gz 2.6 GB
EGAF00004150698 fastq.gz 4.8 GB
EGAF00004150699 fastq.gz 4.9 GB
EGAF00004150700 fastq.gz 3.0 GB
EGAF00004150701 fastq.gz 3.3 GB
EGAF00004150702 fastq.gz 2.0 GB
EGAF00004150703 fastq.gz 2.0 GB
EGAF00004150704 fastq.gz 2.8 GB
EGAF00004150705 fastq.gz 3.0 GB
EGAF00004150706 fastq.gz 2.2 GB
EGAF00004150707 fastq.gz 2.3 GB
EGAF00004150708 fastq.gz 1.2 GB
EGAF00004150709 fastq.gz 1.3 GB
EGAF00004150710 fastq.gz 2.9 GB
EGAF00004150711 fastq.gz 3.1 GB
EGAF00004150712 fastq.gz 9.0 GB
EGAF00004150713 fastq.gz 9.5 GB
EGAF00004150714 fastq.gz 2.7 GB
EGAF00004150715 fastq.gz 2.8 GB
EGAF00004150716 fastq.gz 748.1 MB
EGAF00004150717 fastq.gz 839.5 MB
EGAF00004150718 fastq.gz 2.8 GB
EGAF00004150719 fastq.gz 3.1 GB
EGAF00004150720 fastq.gz 3.3 GB
EGAF00004150721 fastq.gz 3.4 GB
EGAF00004150722 fastq.gz 5.7 GB
EGAF00004150723 fastq.gz 6.1 GB
EGAF00004150724 fastq.gz 3.5 GB
EGAF00004150725 fastq.gz 3.8 GB
EGAF00004150726 fastq.gz 4.2 GB
EGAF00004150727 fastq.gz 4.4 GB
EGAF00004150728 fastq.gz 2.5 GB
EGAF00004150729 fastq.gz 2.5 GB
EGAF00004150730 fastq.gz 2.1 GB
EGAF00004150731 fastq.gz 2.3 GB
EGAF00004150732 fastq.gz 2.5 GB
EGAF00004150733 fastq.gz 2.6 GB
EGAF00004150734 fastq.gz 5.1 GB
EGAF00004150735 fastq.gz 5.6 GB
EGAF00004150736 fastq.gz 5.6 GB
EGAF00004150737 fastq.gz 5.8 GB
EGAF00004150738 fastq.gz 603.6 MB
EGAF00004150739 fastq.gz 659.0 MB
EGAF00004150740 fastq.gz 773.4 MB
EGAF00004150741 fastq.gz 822.4 MB
EGAF00004150742 fastq.gz 566.7 MB
EGAF00004150743 fastq.gz 586.0 MB
EGAF00004150744 fastq.gz 703.0 MB
EGAF00004150745 fastq.gz 725.8 MB
EGAF00004150746 fastq.gz 738.6 MB
EGAF00004150747 fastq.gz 771.0 MB
EGAF00004150748 fastq.gz 593.4 MB
EGAF00004150749 fastq.gz 613.3 MB
EGAF00004150750 fastq.gz 419.7 MB
EGAF00004150751 fastq.gz 425.3 MB
EGAF00004150752 fastq.gz 420.1 MB
EGAF00004150753 fastq.gz 428.9 MB
EGAF00004150754 fastq.gz 1.2 GB
EGAF00004150755 fastq.gz 1.3 GB
EGAF00004150756 fastq.gz 1.2 GB
EGAF00004150757 fastq.gz 1.3 GB
EGAF00004150758 fastq.gz 1.2 GB
EGAF00004150759 fastq.gz 1.3 GB
EGAF00004150760 fastq.gz 1.2 GB
EGAF00004150761 fastq.gz 1.4 GB
EGAF00004150762 fastq.gz 1.0 GB
EGAF00004150763 fastq.gz 1.2 GB
EGAF00004150764 fastq.gz 1.1 GB
EGAF00004150765 fastq.gz 1.2 GB
EGAF00004150766 fastq.gz 1.1 GB
EGAF00004150767 fastq.gz 1.3 GB
EGAF00004150768 fastq.gz 1.0 GB
EGAF00004150769 fastq.gz 1.1 GB
EGAF00004150770 fastq.gz 1.4 GB
EGAF00004150771 fastq.gz 1.6 GB
EGAF00004150772 fastq.gz 1.3 GB
EGAF00004150773 fastq.gz 1.5 GB
EGAF00004150774 fastq.gz 1.3 GB
EGAF00004150775 fastq.gz 1.5 GB
EGAF00004150776 fastq.gz 1.3 GB
EGAF00004150777 fastq.gz 1.5 GB
EGAF00004150778 fastq.gz 1.1 GB
EGAF00004150779 fastq.gz 1.3 GB
EGAF00004150780 fastq.gz 1.2 GB
EGAF00004150781 fastq.gz 1.4 GB
EGAF00004150782 fastq.gz 1.4 GB
EGAF00004150783 fastq.gz 1.6 GB
EGAF00004150784 fastq.gz 1.1 GB
EGAF00004150785 fastq.gz 1.3 GB
EGAF00004150786 fastq.gz 1.5 GB
EGAF00004150787 fastq.gz 1.7 GB
EGAF00004150788 fastq.gz 998.6 MB
EGAF00004150789 fastq.gz 1.1 GB
EGAF00004150790 fastq.gz 1.2 GB
EGAF00004150791 fastq.gz 1.3 GB
EGAF00004150792 fastq.gz 1.0 GB
EGAF00004150793 fastq.gz 1.2 GB
EGAF00004150794 fastq.gz 1.4 GB
EGAF00004150795 fastq.gz 1.5 GB
EGAF00004150796 fastq.gz 1.2 GB
EGAF00004150797 fastq.gz 1.4 GB
EGAF00004150798 fastq.gz 1.3 GB
EGAF00004150799 fastq.gz 1.4 GB
EGAF00004150800 fastq.gz 1.4 GB
EGAF00004150801 fastq.gz 1.5 GB
EGAF00004150802 fastq.gz 1.3 GB
EGAF00004150803 fastq.gz 1.4 GB
EGAF00004150804 fastq.gz 930.7 MB
EGAF00004150805 fastq.gz 1.1 GB
EGAF00004150806 fastq.gz 1.1 GB
EGAF00004150807 fastq.gz 1.2 GB
EGAF00004150808 fastq.gz 1.3 GB
EGAF00004150809 fastq.gz 1.4 GB
EGAF00004150810 fastq.gz 1.3 GB
EGAF00004150811 fastq.gz 1.5 GB
EGAF00004150812 fastq.gz 1.6 GB
EGAF00004150813 fastq.gz 1.8 GB
158 Files (354.6 GB)