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The Transcriptional Landscape of SHH Medulloblastoma

To further understand the biology of Sonic hedgehog medulloblastoma and its molecular subtypes, we studied 250 human Shh-MB using strand-specific RNA sequencing. We identified novel alterations within the cAMP dependent pathway and found that 18% of tumors have genetic events that directly target the abundance and/or stability of MYCN. We also discovered an extensive network of fusions in focally amplified regions, and several loss-of-function fusions in tumor suppressor genes PTCH, SUFU and NCOR1. Molecular convergence on a core of specific genes by nucleotide variants, copy number aberrations, and gene fusions highlights key roles of specific pathways in the pathogenesis of Sonic hedgehog medulloblastoma.

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Genotype/expression array/sequence data generated by MDT lab in Hospital for Sick Children

To access Controlled Access data, please contact us.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002218097 fastq.gz 8.2 GB
EGAF00002218098 fastq.gz 8.4 GB
EGAF00004953908 fastq.gz 10.5 GB
EGAF00004953909 fastq.gz 10.9 GB
EGAF00004953910 fastq.gz 9.3 GB
EGAF00004953911 fastq.gz 9.9 GB
EGAF00004953912 fastq.gz 7.7 GB
EGAF00004953913 fastq.gz 8.2 GB
EGAF00004953914 fastq.gz 10.4 GB
EGAF00004953915 fastq.gz 10.8 GB
EGAF00004953916 fastq.gz 9.7 GB
EGAF00004953917 fastq.gz 9.9 GB
EGAF00004953918 fastq.gz 9.0 GB
EGAF00004953919 fastq.gz 10.1 GB
EGAF00004953920 fastq.gz 12.8 GB
EGAF00004953921 fastq.gz 13.3 GB
EGAF00004953922 fastq.gz 11.3 GB
EGAF00004953923 fastq.gz 11.6 GB
EGAF00004953924 fastq.gz 7.2 GB
EGAF00004953925 fastq.gz 7.4 GB
EGAF00004953926 fastq.gz 10.2 GB
EGAF00004953927 fastq.gz 10.4 GB
EGAF00004953928 fastq.gz 5.7 GB
EGAF00004953929 fastq.gz 6.1 GB
EGAF00004953930 fastq.gz 7.8 GB
EGAF00004953931 fastq.gz 8.5 GB
EGAF00004953932 fastq.gz 6.8 GB
EGAF00004953933 fastq.gz 7.0 GB
EGAF00004953934 fastq.gz 10.4 GB
EGAF00004953935 fastq.gz 10.7 GB
EGAF00004953936 fastq.gz 9.6 GB
EGAF00004953937 fastq.gz 9.8 GB
EGAF00004953938 fastq.gz 9.9 GB
EGAF00004953939 fastq.gz 10.4 GB
EGAF00004953940 fastq.gz 9.6 GB
EGAF00004953941 fastq.gz 10.0 GB
EGAF00004953942 fastq.gz 10.0 GB
EGAF00004953943 fastq.gz 10.4 GB
EGAF00004953944 fastq.gz 9.3 GB
EGAF00004953945 fastq.gz 9.7 GB
EGAF00004953946 fastq.gz 9.5 GB
EGAF00004953947 fastq.gz 9.8 GB
EGAF00004953948 fastq.gz 8.6 GB
EGAF00004953949 fastq.gz 8.7 GB
EGAF00004953950 fastq.gz 9.7 GB
EGAF00004953951 fastq.gz 9.9 GB
EGAF00004953952 fastq.gz 15.8 GB
EGAF00004953953 fastq.gz 16.1 GB
EGAF00004953954 fastq.gz 9.8 GB
EGAF00004953955 fastq.gz 9.9 GB
EGAF00004953956 fastq.gz 23.9 GB
EGAF00004953957 fastq.gz 23.9 GB
EGAF00004953958 fastq.gz 11.3 GB
EGAF00004953959 fastq.gz 11.7 GB
EGAF00004953960 fastq.gz 11.5 GB
EGAF00004953961 fastq.gz 11.9 GB
EGAF00004953962 fastq.gz 10.4 GB
EGAF00004953963 fastq.gz 10.8 GB
EGAF00004953964 fastq.gz 10.9 GB
EGAF00004953965 fastq.gz 11.2 GB
EGAF00004953966 fastq.gz 9.8 GB
EGAF00004953967 fastq.gz 10.2 GB
EGAF00004953968 fastq.gz 9.1 GB
EGAF00004953969 fastq.gz 9.2 GB
EGAF00004953970 fastq.gz 8.2 GB
EGAF00004953971 fastq.gz 8.1 GB
EGAF00004953972 fastq.gz 13.1 GB
EGAF00004953973 fastq.gz 12.9 GB
EGAF00004953974 fastq.gz 10.2 GB
EGAF00004953975 fastq.gz 10.2 GB
EGAF00004953976 fastq.gz 10.5 GB
EGAF00004953977 fastq.gz 10.5 GB
EGAF00004953978 fastq.gz 9.3 GB
EGAF00004953979 fastq.gz 9.4 GB
EGAF00004953980 fastq.gz 10.5 GB
EGAF00004953981 fastq.gz 10.6 GB
EGAF00004953982 fastq.gz 9.1 GB
EGAF00004953983 fastq.gz 9.1 GB
EGAF00004953984 fastq.gz 11.7 GB
EGAF00004953985 fastq.gz 11.8 GB
EGAF00004953986 fastq.gz 9.7 GB
EGAF00004953987 fastq.gz 9.6 GB
EGAF00004953988 fastq.gz 11.6 GB
EGAF00004953989 fastq.gz 11.5 GB
EGAF00004953990 fastq.gz 12.0 GB
EGAF00004953991 fastq.gz 12.1 GB
EGAF00004953992 fastq.gz 8.8 GB
EGAF00004953993 fastq.gz 8.8 GB
EGAF00004953994 fastq.gz 9.6 GB
EGAF00004953995 fastq.gz 9.6 GB
EGAF00004953996 fastq.gz 9.6 GB
EGAF00004953997 fastq.gz 9.7 GB
EGAF00004953998 fastq.gz 10.4 GB
EGAF00004953999 fastq.gz 10.4 GB
EGAF00004954000 fastq.gz 8.5 GB
EGAF00004954001 fastq.gz 8.5 GB
EGAF00004954002 fastq.gz 10.0 GB
EGAF00004954003 fastq.gz 10.1 GB
EGAF00004954004 fastq.gz 10.8 GB
EGAF00004954005 fastq.gz 10.8 GB
EGAF00004954006 fastq.gz 8.8 GB
EGAF00004954007 fastq.gz 8.9 GB
EGAF00004954008 fastq.gz 9.4 GB
EGAF00004954009 fastq.gz 9.3 GB
EGAF00004954010 fastq.gz 9.3 GB
EGAF00004954011 fastq.gz 9.3 GB
EGAF00004954012 fastq.gz 12.1 GB
EGAF00004954013 fastq.gz 12.2 GB
EGAF00004954014 fastq.gz 9.0 GB
EGAF00004954015 fastq.gz 9.0 GB
EGAF00004954016 fastq.gz 11.4 GB
EGAF00004954017 fastq.gz 11.4 GB
EGAF00004954018 fastq.gz 9.8 GB
EGAF00004954019 fastq.gz 9.8 GB
EGAF00004954020 fastq.gz 9.0 GB
EGAF00004954021 fastq.gz 9.0 GB
EGAF00004954022 fastq.gz 6.7 GB
EGAF00004954023 fastq.gz 6.7 GB
EGAF00004954024 fastq.gz 8.3 GB
EGAF00004954025 fastq.gz 8.5 GB
EGAF00004954026 fastq.gz 11.6 GB
EGAF00004954027 fastq.gz 11.2 GB
EGAF00004954028 fastq.gz 10.0 GB
EGAF00004954029 fastq.gz 10.0 GB
EGAF00004954030 fastq.gz 10.4 GB
EGAF00004954031 fastq.gz 10.4 GB
EGAF00004954032 fastq.gz 11.7 GB
EGAF00004954033 fastq.gz 11.8 GB
EGAF00004954034 fastq.gz 10.6 GB
EGAF00004954035 fastq.gz 10.6 GB
EGAF00004954036 fastq.gz 9.6 GB
EGAF00004954037 fastq.gz 9.6 GB
EGAF00004954038 fastq.gz 7.9 GB
EGAF00004954039 fastq.gz 7.9 GB
EGAF00004954040 fastq.gz 10.9 GB
EGAF00004954041 fastq.gz 11.1 GB
EGAF00004954042 fastq.gz 11.2 GB
EGAF00004954043 fastq.gz 11.4 GB
EGAF00004954044 fastq.gz 10.0 GB
EGAF00004954045 fastq.gz 10.0 GB
EGAF00004954046 fastq.gz 13.7 GB
EGAF00004954047 fastq.gz 13.8 GB
EGAF00004954048 fastq.gz 9.7 GB
EGAF00004954049 fastq.gz 10.0 GB
EGAF00004954050 fastq.gz 10.7 GB
EGAF00004954051 fastq.gz 10.4 GB
EGAF00004954052 fastq.gz 11.1 GB
EGAF00004954053 fastq.gz 11.2 GB
EGAF00004954054 fastq.gz 13.2 GB
EGAF00004954055 fastq.gz 13.4 GB
EGAF00004954056 fastq.gz 8.0 GB
EGAF00004954057 fastq.gz 7.9 GB
EGAF00004954058 fastq.gz 12.7 GB
EGAF00004954059 fastq.gz 12.8 GB
EGAF00004954060 fastq.gz 8.6 GB
EGAF00004954061 fastq.gz 8.6 GB
EGAF00004954062 fastq.gz 9.6 GB
EGAF00004954063 fastq.gz 9.6 GB
EGAF00004954064 fastq.gz 9.3 GB
EGAF00004954065 fastq.gz 9.5 GB
EGAF00004954066 fastq.gz 7.9 GB
EGAF00004954067 fastq.gz 7.9 GB
EGAF00004954068 fastq.gz 9.8 GB
EGAF00004954069 fastq.gz 9.8 GB
164 Files (1.7 TB)