Survival Benefit and Genetic Profile of Pemetrexed as Initial Chemotherapy in Selected Chinese Patients with Advanced Lung Adenocarcinoma

Agreement for accessing data of NGS based ctDNA tests

Data Access Agreement I. DEFINITIONS AND INTERPRETATIONS 1) “Data producers” refer to “Geneseeq Technology Inc.” 2) “User Institution” refers to institution requesting data access. 3) “Authorized Personnel” refers to individuals in the User Institution that are granted data access, including principle investigators who submit the application and other registered users in Appendix I. II. TERMS AND CONDITIONS 1) The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix I) and only for Research Purposes. Description of research projects (Appendix I) need to be submitted and reviewed by Data Access Committee (DCA) before data access. 2) Minimum protection measures are required for file access. Unencrypted data files can be held on a secured institutional compute system. It is suggested to set password logins and screenlocks for the data storage computers. For data transportation with USB or other portable hard drives, the data must be encrypted. 3) The User Institution agrees to preserve, at all times, the confidentiality of these Data. It is required to take all reasonable care to limit the possibility of identifying Research Participants in any research papers or publications. 4) The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorized Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 5) The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 6) The User Institution agrees to follow the Fort Lauderdale Guidelines (https://wellcome.ac.uk/sites/default/files/wtd003207_0.pdf) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognizing the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 7) The User Institution agrees to follow the Publication Policy in Appendix II. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analyzing these Data. 8) The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 9) The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 10) The User Institution will notify Geneseeq Technology Inc. within 30 days of any changes or departures of Authorized Personnel. 11) The User Institution will notify Geneseeq Technology Inc. prior to any significant changes to the protocol for the Project. 12) The User Institution will notify Geneseeq Technology Inc. as soon as it becomes aware of a breach of the terms or conditions of this agreement. 13) Geneseeq Technology Inc. may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. In the event that changes are required, the Data Producers will inform the User Institution of the changes and the User Institution may elect to accept the changes or terminate the agreement. 14) If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. APPENDIX I – APPLICANT INFORMATION 1. Name of User Institute 2. Project name 3. Project description and research aims 4. Information of principle investigator* 1) Name: 2) Position: 3) Institutional email address: 4) Phone Number: 5) Full postal address: 6) Registered users in this project (Include the information of all students and research staff who will have access to the data for the project): a. Name of Registered User b. Institutional Email c. Job Title *Co-investigators or collaborators in other Institutions must submit a separate data access application. APPENDIX II – PUBLICATION POLICY Data producers intend to publish the results of their analysis of this dataset and do not consider its deposition into public databases to be the equivalent of such publications. Data producers anticipate that the dataset could be useful to other qualified researchers for a variety of purposes. However, some areas of work are subject to a publication moratorium. The publication moratorium covers any publications (including oral communications) that describe the use of the dataset. For research papers, submission for publication should not occur until 24 months after these data were first made available on the relevant hosting database, unless Data producers has provided written consent to earlier submission. In any publications based on these data, please describe how the data can be accessed, including the name of the hosting database (e.g., The European Genome-phenome Archive at the European Bioinformatics Institute) and its accession numbers (e.g., EGAS00000000029), and acknowledge its use in a form agreed by the User Institution with Data producers.