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Conserved interferon-gamma signaling and decreased immune exclusion programs in responses to immune checkpoint blockade therapy_CM38-RNA

We analyzed baseline and on-therapy tumor biopsies from 101 patients with advanced melanoma treated with nivolumab (anti-PD-1) alone or combined with ipilimumab (anti-CTLA-4). Analysis of whole transcriptome data showed that T cell infiltration and interferon-gamma signaling signatures corresponded most highly with clinical response to therapy, with a reciprocal decrease in cell cycle and WNT signaling pathways in responding biopsies. Clinical outcome differences were likely not due to differential melanoma cell responses to interferon-gamma, as 57 human melanoma cell lines exposed in vitro to this cytokine showed a conserved interferon-gamma transcriptome response unless they had mutations that precluded signaling from the interferon-gamma receptor. Therefore, the magnitude of the antitumor T cell response and the corresponding downstream interferon-gamma signaling are the main drivers of clinical response or resistance to immune checkpoint blockade therapy.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00004172723 fastq.gz 2.3 GB
EGAF00004172724 fastq.gz 2.4 GB
EGAF00004172725 fastq.gz 2.6 GB
EGAF00004172726 fastq.gz 2.7 GB
EGAF00004172727 fastq.gz 2.7 GB
EGAF00004172728 fastq.gz 2.9 GB
EGAF00004172729 fastq.gz 2.2 GB
EGAF00004172730 fastq.gz 2.3 GB
EGAF00004172731 fastq.gz 2.0 GB
EGAF00004172732 fastq.gz 2.2 GB
EGAF00004172733 fastq.gz 2.5 GB
EGAF00004172734 fastq.gz 2.5 GB
EGAF00004172735 fastq.gz 2.2 GB
EGAF00004172736 fastq.gz 2.4 GB
EGAF00004172737 fastq.gz 2.1 GB
EGAF00004172738 fastq.gz 2.3 GB
EGAF00004172739 fastq.gz 2.1 GB
EGAF00004172740 fastq.gz 2.3 GB
EGAF00004172741 fastq.gz 2.2 GB
EGAF00004172742 fastq.gz 2.4 GB
EGAF00004172743 fastq.gz 2.6 GB
EGAF00004172744 fastq.gz 2.6 GB
EGAF00004172745 fastq.gz 2.4 GB
EGAF00004172746 fastq.gz 2.7 GB
EGAF00004172747 fastq.gz 2.3 GB
EGAF00004172748 fastq.gz 2.3 GB
EGAF00004172749 fastq.gz 2.3 GB
EGAF00004172750 fastq.gz 2.3 GB
EGAF00004172751 fastq.gz 2.6 GB
EGAF00004172752 fastq.gz 2.7 GB
EGAF00004172753 fastq.gz 2.2 GB
EGAF00004172754 fastq.gz 2.3 GB
EGAF00004172755 fastq.gz 2.3 GB
EGAF00004172756 fastq.gz 2.5 GB
EGAF00004172757 fastq.gz 2.3 GB
EGAF00004172758 fastq.gz 2.4 GB
EGAF00004172759 fastq.gz 2.4 GB
EGAF00004172760 fastq.gz 2.6 GB
EGAF00004172761 fastq.gz 2.2 GB
EGAF00004172762 fastq.gz 2.4 GB
EGAF00004172763 fastq.gz 2.2 GB
EGAF00004172764 fastq.gz 2.4 GB
EGAF00004172765 fastq.gz 2.1 GB
EGAF00004172766 fastq.gz 2.3 GB
EGAF00004172767 fastq.gz 2.1 GB
EGAF00004172768 fastq.gz 2.3 GB
EGAF00004172769 fastq.gz 2.2 GB
EGAF00004172770 fastq.gz 2.3 GB
EGAF00004172771 fastq.gz 4.2 GB
EGAF00004172772 fastq.gz 4.2 GB
EGAF00004172773 fastq.gz 2.4 GB
EGAF00004172774 fastq.gz 2.6 GB
EGAF00004172775 fastq.gz 2.1 GB
EGAF00004172776 fastq.gz 2.3 GB
EGAF00004172777 fastq.gz 2.0 GB
EGAF00004172778 fastq.gz 2.2 GB
EGAF00004172779 fastq.gz 2.3 GB
EGAF00004172780 fastq.gz 2.4 GB
EGAF00004172781 fastq.gz 2.1 GB
EGAF00004172782 fastq.gz 2.2 GB
EGAF00004172783 fastq.gz 2.1 GB
EGAF00004172784 fastq.gz 2.2 GB
EGAF00004172785 fastq.gz 2.1 GB
EGAF00004172786 fastq.gz 2.2 GB
EGAF00004172787 fastq.gz 2.2 GB
EGAF00004172788 fastq.gz 2.4 GB
EGAF00004172789 fastq.gz 2.6 GB
EGAF00004172790 fastq.gz 2.6 GB
EGAF00004172791 fastq.gz 2.6 GB
EGAF00004172792 fastq.gz 2.7 GB
EGAF00004172793 fastq.gz 2.1 GB
EGAF00004172794 fastq.gz 2.3 GB
EGAF00004172795 fastq.gz 2.4 GB
EGAF00004172796 fastq.gz 2.5 GB
EGAF00004172797 fastq.gz 2.2 GB
EGAF00004172798 fastq.gz 2.3 GB
EGAF00004172799 fastq.gz 2.6 GB
EGAF00004172800 fastq.gz 2.7 GB
EGAF00004172801 fastq.gz 2.4 GB
EGAF00004172802 fastq.gz 2.5 GB
EGAF00004172803 fastq.gz 2.1 GB
EGAF00004172804 fastq.gz 2.2 GB
EGAF00004172805 fastq.gz 2.2 GB
EGAF00004172806 fastq.gz 2.3 GB
EGAF00004172807 fastq.gz 2.2 GB
EGAF00004172808 fastq.gz 2.3 GB
EGAF00004172809 fastq.gz 2.1 GB
EGAF00004172810 fastq.gz 2.2 GB
EGAF00004172811 fastq.gz 2.1 GB
EGAF00004172812 fastq.gz 2.3 GB
EGAF00004172813 fastq.gz 2.2 GB
EGAF00004172814 fastq.gz 2.3 GB
EGAF00004172815 fastq.gz 2.2 GB
EGAF00004172816 fastq.gz 2.4 GB
EGAF00004172817 fastq.gz 2.1 GB
EGAF00004172818 fastq.gz 2.4 GB
EGAF00004172819 fastq.gz 2.6 GB
EGAF00004172820 fastq.gz 2.8 GB
EGAF00004172821 fastq.gz 2.2 GB
EGAF00004172822 fastq.gz 2.4 GB
EGAF00004172823 fastq.gz 2.2 GB
EGAF00004172824 fastq.gz 2.4 GB
EGAF00004172825 fastq.gz 2.6 GB
EGAF00004172826 fastq.gz 2.7 GB
EGAF00004172827 fastq.gz 2.3 GB
EGAF00004172828 fastq.gz 2.3 GB
EGAF00004172829 fastq.gz 2.1 GB
EGAF00004172830 fastq.gz 2.2 GB
108 Files (256.3 GB)