MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas
Temozolomide (TMZ) is an oral alkylating agent used for the treatment of glioblastoma and is now becoming a chemotherapeutic option in patients diagnosed with high-risk low-grade gliomas. The O-6-methylguanine-DNA methyltransferase (MGMT) is responsible for the direct repair of the main TMZ-induced toxic DNA adduct, the O6-Methylguanine lesion. MGMT promoter hypermethylation is currently the only known biomarker for TMZ response in glioblastoma patients. Here we show that a subset of recurrent gliomas carry MGMT genomic rearrangements that lead to MGMT overexpression, independently from changes in its promoter methylation. By leveraging the CRISPR/Cas9 technology we generated some of these MGMT rearrangements in glioma cells and demonstrated that they lead to TMZ resistance both in vitro and in vivo. Lastly we showed that such fusions can be detected in tumor-derived exosomes and could potentially represent an early detection marker of tumor recurrence in a subset of patients treated with TMZ.
- 136 samples
- DAC: EGAC00001001664
- Technology: Illumina HiSeq 2500
- HMB DUO:0000006 (version: 2019-01-07)health or medical or biomedical researchThis data use permission indicates that use is allowed for health/medical/biomedical purposes; does not include the study of population origins or ancestry.
- RU DUO:0000014 (version: 2019-01-07)research use onlyThis data use limitation indicates that use is limited to research purposes (e.g., does not include its use in clinical care).
- TS DUO:0000025 (version: 2019-01-07)time limit on useThis data use modifier indicates that use is approved for a specific number of months.
- PS DUO:0000027 (version: 2019-01-07)project specific restrictionThis data use modifier indicates that use is limited to use within an approved project.
CGGA Data Access Policy
This policy governs the terms of access to the de-identified dataset consisting of RNA sequencing data from temozolomide treated recurrent glioma patients generated at BNI under the direction of Tao Jiang, Ph.D. 1. Responsibility of Research The Data Set was collected in accordance with applicable laws, regulations, patient consent forms and authorizations pursuant to Institutional Review Board (IRB) approval. 2. Responsibility of Data Recipient Data Recipient agrees that: a. the Data Set shall be used solely for the Study described in Section A; b. any additional uses of the Data Set by the Data Recipient shall be covered under a separate agreement; c. the Data Set shall be used in compliance with all applicable local, state and federal statutes and regulations; d. the Data Set shall be used only at the Institution by the Principal Investigator and the Other Users working under his/her direct supervision; Principal Investigator will notify the BJNI Principal Investigator of any departures of the Principal Investigator or Other Users within 30 days of the changes made. e. the Data Set shall not be transferred, in whole or in part, to anyone outside the Institution without prior written consent of BNI. f. Data Recipient will not contact or make any effort to identify individuals who are or may be included in the Data Set. 3. Confidentiality Data Recipient shall not disclose the Data Set to anyone except the Principal Investigator and the Other Users for the purposes of the Study. The Data Recipient will use the Data Set only in the conduct of the Study and evaluation of its results. Data Recipient agrees to preserve, at all times, the confidentiality of the Data Set. Data Recipient will use the Data Set in a secure manner using appropriate administrative, physical storage and technical safeguards to prevent use or disclosure of the data other than as provided for in this Agreement. Data Recipient agrees to notify the BNI Principal Investigator within 5 days of becoming aware of any use or disclosure of the Data Set in violation of this Agreement. 4. Publication Data Recipient agrees to acknowledge the BNI Principal Investigator in any publication, presentation, abstract or other work based in whole or in part on the Data Set. Data Recipient will cite the BNI Secondary GBM Genomics Data Set as the source of the data in the methods (Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor). 5. Intellectual Property Inventorship of inventions invented by Data Recipient in the performance of the Study (“Inventions”) shall be determined according to P.R China patent law and ownership will vest in the party to whom the inventor has an obligation to assign all right, title and interest in the Invention. Nothing in this Agreement grants Data Recipient any rights to use the Data Set for commercial purposes. BNI explicitly retains ownership of the Data Set and this Agreement does not restrict BNI’s right to distribute the Data Set to other entities. Notwithstanding the foregoing, Data Recipient shall not pursue intellectual property rights which occur as a result of the use of the Data Set in the performance of the Study without first notifying BNI so that BNI can assert claims to legal inventorship under P.R. China law. Data Recipient agrees not to make intellectual property claims on the Data Set and not to use intellectual property protection in ways that would prevent or block access to the Data Set. This Agreement in no way alters any rights or interests of the P.R. China government. 6. Limitation of Liability THE DATA SET IS EXPERIMENTAL IN CELL AND IS BEING MADE AVAILABLE TO RECIPIENT WITH NO WARRANTIES, EXPRESS OR IMPLIED, OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE OR OTHERWISE. IN PARTICULAR, BNI DOES NOT REPRESENT OR WARRANT THAT THE USE OF THE DATA SET WILL NOT INFRINGE OR VIOLATE ANY PATENT OR PROPRIETARY RIGHTS OF THIRD PARTIES. To the extent permitted by law, Institution assumes all liability for damages which may arise from the use, storage or disposal of the Data Set by Data Recipient. BNI (including, but not limited to, its directors, trustees, officers employees, students and agents, as applicable), will not be liable to the Data Recipient for any loss, claim or demand made by or against the Data Recipient or Other Users, due to or arising from the use of the Data Set by the Data Recipient or Other Users or due to unavailability of or interruption in Data Set access for whatever reason, except to the extent caused by the gross negligence or willful misconduct of the BNI. To the extent allowable under applicable laws, Institution agrees to indemnify, defend and hold harmless BNI and its trustees, officers, staff, representatives and agents against all damages, expenses (including without limitation legal expenses), claims, demands, suits or other actions arising from Data Recipient’s acceptance, storage, use and disposal of the Data Set, but only in proportion to and to the extent such are caused by or result from the negligent or intentional acts or omissions of Data Recipient, Other Users, or Institution’s officers, agents or employees. 7. Assignment. This agreement is not assignable by Institution. 8. Term and Termination The term of this agreement shall commence on the Effective Date and shall continue for as long as the Data Recipient retains the Data Set, unless terminated sooner as set forth in this Agreement. The Data Recipient may terminate this Agreement at any time by notifying the BNI Principal Investigator. BNI may terminate this Agreement at any time upon breach of this Agreement by Data Recipient. In the event of termination, Data Recipient shall destroy the Data Set and all copies in its possession, including all documents created by Data Recipient where portions of the Data Set are reproduced. 9. Agreement If Data Recipient agrees to the above terms and conditions for access to the Data Set, please so indicate by returning one copy of this Agreement signed by a duly authorized representative of Institution and by Principal Investigator. Upon receipt of signed Agreement by Institution and Principal Investigator, access to the Data Set will be provided to the Principal Investigator. Principal Investigator agrees to distribute a copy of this agreement and explain its content to any Other Users, and will ensure that they acknowledge their obligations to abide by the terms of this Agreement in their use of the Data Set.
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| Other |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Located in | |
|---|---|---|---|---|
| EGAF00004172451 | fastq.gz | 3.8 GB | ||
| EGAF00004172452 | fastq.gz | 4.1 GB | ||
| EGAF00004172453 | fastq.gz | 1.2 GB | ||
| EGAF00004172454 | fastq.gz | 1.2 GB | ||
| EGAF00004172455 | fastq.gz | 4.0 GB | ||
| EGAF00004172456 | fastq.gz | 4.4 GB | ||
| EGAF00004172457 | fastq.gz | 1.6 GB | ||
| EGAF00004172458 | fastq.gz | 1.6 GB | ||
| EGAF00004172459 | fastq.gz | 3.0 GB | ||
| EGAF00004172460 | fastq.gz | 3.3 GB | ||
| EGAF00004172461 | fastq.gz | 3.8 GB | ||
| EGAF00004172462 | fastq.gz | 4.1 GB | ||
| EGAF00004172463 | fastq.gz | 4.6 GB | ||
| EGAF00004172464 | fastq.gz | 5.0 GB | ||
| EGAF00004172465 | fastq.gz | 1.5 GB | ||
| EGAF00004172466 | fastq.gz | 1.5 GB | ||
| EGAF00004172467 | fastq.gz | 2.9 GB | ||
| EGAF00004172468 | fastq.gz | 3.1 GB | ||
| EGAF00004172469 | fastq.gz | 3.0 GB | ||
| EGAF00004172470 | fastq.gz | 3.3 GB | ||
| EGAF00004172471 | fastq.gz | 3.3 GB | ||
| EGAF00004172472 | fastq.gz | 3.6 GB | ||
| EGAF00004172473 | fastq.gz | 3.6 GB | ||
| EGAF00004172474 | fastq.gz | 3.8 GB | ||
| EGAF00004172475 | fastq.gz | 2.8 GB | ||
| EGAF00004172476 | fastq.gz | 3.1 GB | ||
| EGAF00004172477 | fastq.gz | 4.1 GB | ||
| EGAF00004172478 | fastq.gz | 4.5 GB | ||
| EGAF00004172479 | fastq.gz | 2.4 GB | ||
| EGAF00004172480 | fastq.gz | 2.4 GB | ||
| EGAF00004172481 | fastq.gz | 3.8 GB | ||
| EGAF00004172482 | fastq.gz | 4.5 GB | ||
| EGAF00004172483 | fastq.gz | 4.3 GB | ||
| EGAF00004172484 | fastq.gz | 4.9 GB | ||
| EGAF00004172485 | fastq.gz | 3.2 GB | ||
| EGAF00004172486 | fastq.gz | 3.2 GB | ||
| EGAF00004172487 | fastq.gz | 4.7 GB | ||
| EGAF00004172488 | fastq.gz | 5.2 GB | ||
| EGAF00004172489 | fastq.gz | 1.7 GB | ||
| EGAF00004172490 | fastq.gz | 1.8 GB | ||
| EGAF00004172491 | fastq.gz | 2.6 GB | ||
| EGAF00004172492 | fastq.gz | 2.6 GB | ||
| EGAF00004172493 | fastq.gz | 2.9 GB | ||
| EGAF00004172494 | fastq.gz | 3.4 GB | ||
| EGAF00004172495 | fastq.gz | 4.4 GB | ||
| EGAF00004172496 | fastq.gz | 4.6 GB | ||
| EGAF00004172497 | fastq.gz | 3.9 GB | ||
| EGAF00004172498 | fastq.gz | 4.4 GB | ||
| EGAF00004172499 | fastq.gz | 1.5 GB | ||
| EGAF00004172500 | fastq.gz | 1.5 GB | ||
| EGAF00004172501 | fastq.gz | 4.2 GB | ||
| EGAF00004172502 | fastq.gz | 4.6 GB | ||
| EGAF00004172503 | fastq.gz | 3.8 GB | ||
| EGAF00004172504 | fastq.gz | 4.3 GB | ||
| EGAF00004172505 | fastq.gz | 3.2 GB | ||
| EGAF00004172506 | fastq.gz | 3.6 GB | ||
| EGAF00004172507 | fastq.gz | 3.1 GB | ||
| EGAF00004172508 | fastq.gz | 3.4 GB | ||
| EGAF00004172509 | fastq.gz | 5.2 GB | ||
| EGAF00004172510 | fastq.gz | 5.4 GB | ||
| EGAF00004172511 | fastq.gz | 3.6 GB | ||
| EGAF00004172512 | fastq.gz | 3.8 GB | ||
| EGAF00004172513 | fastq.gz | 2.8 GB | ||
| EGAF00004172514 | fastq.gz | 3.2 GB | ||
| EGAF00004172515 | fastq.gz | 3.6 GB | ||
| EGAF00004172516 | fastq.gz | 3.9 GB | ||
| EGAF00004172517 | fastq.gz | 1.2 GB | ||
| EGAF00004172518 | fastq.gz | 1.2 GB | ||
| EGAF00004172519 | fastq.gz | 1.8 GB | ||
| EGAF00004172520 | fastq.gz | 1.8 GB | ||
| EGAF00004172521 | fastq.gz | 3.0 GB | ||
| EGAF00004172522 | fastq.gz | 3.3 GB | ||
| EGAF00004172523 | fastq.gz | 3.5 GB | ||
| EGAF00004172524 | fastq.gz | 3.9 GB | ||
| EGAF00004172525 | fastq.gz | 3.4 GB | ||
| EGAF00004172526 | fastq.gz | 3.8 GB | ||
| EGAF00004172527 | fastq.gz | 3.2 GB | ||
| EGAF00004172528 | fastq.gz | 3.5 GB | ||
| EGAF00004172529 | fastq.gz | 4.3 GB | ||
| EGAF00004172530 | fastq.gz | 4.5 GB | ||
| EGAF00004172531 | fastq.gz | 4.6 GB | ||
| EGAF00004172532 | fastq.gz | 4.5 GB | ||
| EGAF00004172533 | fastq.gz | 2.6 GB | ||
| EGAF00004172534 | fastq.gz | 2.7 GB | ||
| EGAF00004172535 | fastq.gz | 4.7 GB | ||
| EGAF00004172536 | fastq.gz | 5.3 GB | ||
| EGAF00004172537 | fastq.gz | 3.4 GB | ||
| EGAF00004172538 | fastq.gz | 3.7 GB | ||
| EGAF00004172539 | fastq.gz | 1.3 GB | ||
| EGAF00004172540 | fastq.gz | 1.4 GB | ||
| EGAF00004172541 | fastq.gz | 3.0 GB | ||
| EGAF00004172542 | fastq.gz | 3.2 GB | ||
| EGAF00004172543 | fastq.gz | 3.8 GB | ||
| EGAF00004172544 | fastq.gz | 4.0 GB | ||
| EGAF00004172545 | fastq.gz | 3.6 GB | ||
| EGAF00004172546 | fastq.gz | 4.0 GB | ||
| EGAF00004172547 | fastq.gz | 3.7 GB | ||
| EGAF00004172548 | fastq.gz | 4.1 GB | ||
| EGAF00004172549 | fastq.gz | 3.8 GB | ||
| EGAF00004172550 | fastq.gz | 4.2 GB | ||
| EGAF00004172551 | fastq.gz | 2.1 GB | ||
| EGAF00004172552 | fastq.gz | 2.1 GB | ||
| EGAF00004172553 | fastq.gz | 4.1 GB | ||
| EGAF00004172554 | fastq.gz | 4.6 GB | ||
| EGAF00004172555 | fastq.gz | 2.8 GB | ||
| EGAF00004172556 | fastq.gz | 3.0 GB | ||
| EGAF00004172557 | fastq.gz | 3.6 GB | ||
| EGAF00004172558 | fastq.gz | 4.1 GB | ||
| EGAF00004172559 | fastq.gz | 3.4 GB | ||
| EGAF00004172560 | fastq.gz | 3.8 GB | ||
| EGAF00004172561 | fastq.gz | 2.8 GB | ||
| EGAF00004172562 | fastq.gz | 3.2 GB | ||
| EGAF00004172563 | fastq.gz | 1.8 GB | ||
| EGAF00004172564 | fastq.gz | 1.8 GB | ||
| EGAF00004172565 | fastq.gz | 1.4 GB | ||
| EGAF00004172566 | fastq.gz | 1.5 GB | ||
| EGAF00004172567 | fastq.gz | 2.2 GB | ||
| EGAF00004172568 | fastq.gz | 2.3 GB | ||
| EGAF00004172569 | fastq.gz | 3.1 GB | ||
| EGAF00004172570 | fastq.gz | 3.2 GB | ||
| EGAF00004172571 | fastq.gz | 1.9 GB | ||
| EGAF00004172572 | fastq.gz | 2.0 GB | ||
| EGAF00004172573 | fastq.gz | 1.4 GB | ||
| EGAF00004172574 | fastq.gz | 1.5 GB | ||
| EGAF00004172575 | fastq.gz | 3.8 GB | ||
| EGAF00004172576 | fastq.gz | 4.1 GB | ||
| EGAF00004172577 | fastq.gz | 3.7 GB | ||
| EGAF00004172578 | fastq.gz | 4.0 GB | ||
| EGAF00004172579 | fastq.gz | 1.4 GB | ||
| EGAF00004172580 | fastq.gz | 1.4 GB | ||
| EGAF00004172581 | fastq.gz | 3.4 GB | ||
| EGAF00004172582 | fastq.gz | 3.8 GB | ||
| EGAF00004172583 | fastq.gz | 3.3 GB | ||
| EGAF00004172584 | fastq.gz | 3.6 GB | ||
| EGAF00004172585 | fastq.gz | 3.5 GB | ||
| EGAF00004172586 | fastq.gz | 4.1 GB | ||
| EGAF00004172587 | fastq.gz | 3.1 GB | ||
| EGAF00004172588 | fastq.gz | 3.4 GB | ||
| EGAF00004172589 | fastq.gz | 3.1 GB | ||
| EGAF00004172590 | fastq.gz | 3.5 GB | ||
| EGAF00004172591 | fastq.gz | 2.8 GB | ||
| EGAF00004172592 | fastq.gz | 3.0 GB | ||
| EGAF00004172593 | fastq.gz | 3.5 GB | ||
| EGAF00004172594 | fastq.gz | 3.8 GB | ||
| EGAF00004172595 | fastq.gz | 3.5 GB | ||
| EGAF00004172596 | fastq.gz | 3.7 GB | ||
| EGAF00004172597 | fastq.gz | 2.0 GB | ||
| EGAF00004172598 | fastq.gz | 2.0 GB | ||
| EGAF00004172599 | fastq.gz | 4.3 GB | ||
| EGAF00004172600 | fastq.gz | 4.8 GB | ||
| EGAF00004172601 | fastq.gz | 3.7 GB | ||
| EGAF00004172602 | fastq.gz | 4.3 GB | ||
| EGAF00004172603 | fastq.gz | 3.6 GB | ||
| EGAF00004172604 | fastq.gz | 3.8 GB | ||
| EGAF00004172605 | fastq.gz | 3.5 GB | ||
| EGAF00004172606 | fastq.gz | 4.0 GB | ||
| EGAF00004172607 | fastq.gz | 2.9 GB | ||
| EGAF00004172608 | fastq.gz | 3.3 GB | ||
| EGAF00004172609 | fastq.gz | 4.7 GB | ||
| EGAF00004172610 | fastq.gz | 5.4 GB | ||
| EGAF00004172611 | fastq.gz | 3.1 GB | ||
| EGAF00004172612 | fastq.gz | 3.4 GB | ||
| EGAF00004172613 | fastq.gz | 3.0 GB | ||
| EGAF00004172614 | fastq.gz | 3.2 GB | ||
| EGAF00004172615 | fastq.gz | 4.1 GB | ||
| EGAF00004172616 | fastq.gz | 4.7 GB | ||
| EGAF00004172617 | fastq.gz | 3.5 GB | ||
| EGAF00004172618 | fastq.gz | 3.8 GB | ||
| EGAF00004172619 | fastq.gz | 3.5 GB | ||
| EGAF00004172620 | fastq.gz | 3.9 GB | ||
| EGAF00004172621 | fastq.gz | 3.8 GB | ||
| EGAF00004172622 | fastq.gz | 4.1 GB | ||
| EGAF00004172623 | fastq.gz | 4.2 GB | ||
| EGAF00004172624 | fastq.gz | 4.7 GB | ||
| EGAF00004172625 | fastq.gz | 3.9 GB | ||
| EGAF00004172626 | fastq.gz | 4.7 GB | ||
| EGAF00004172627 | fastq.gz | 3.2 GB | ||
| EGAF00004172628 | fastq.gz | 3.4 GB | ||
| EGAF00004172629 | fastq.gz | 2.4 GB | ||
| EGAF00004172630 | fastq.gz | 2.4 GB | ||
| EGAF00004172631 | fastq.gz | 4.2 GB | ||
| EGAF00004172632 | fastq.gz | 4.5 GB | ||
| EGAF00004172633 | fastq.gz | 3.4 GB | ||
| EGAF00004172634 | fastq.gz | 3.8 GB | ||
| EGAF00004172635 | fastq.gz | 2.9 GB | ||
| EGAF00004172636 | fastq.gz | 3.1 GB | ||
| EGAF00004172637 | fastq.gz | 3.3 GB | ||
| EGAF00004172638 | fastq.gz | 3.5 GB | ||
| EGAF00004172639 | fastq.gz | 3.5 GB | ||
| EGAF00004172640 | fastq.gz | 3.8 GB | ||
| EGAF00004172641 | fastq.gz | 4.9 GB | ||
| EGAF00004172642 | fastq.gz | 4.9 GB | ||
| EGAF00004172643 | fastq.gz | 3.3 GB | ||
| EGAF00004172644 | fastq.gz | 3.8 GB | ||
| EGAF00004172645 | fastq.gz | 3.6 GB | ||
| EGAF00004172646 | fastq.gz | 4.2 GB | ||
| EGAF00004172647 | fastq.gz | 3.7 GB | ||
| EGAF00004172648 | fastq.gz | 4.2 GB | ||
| EGAF00004172649 | fastq.gz | 4.7 GB | ||
| EGAF00004172650 | fastq.gz | 4.8 GB | ||
| EGAF00004172651 | fastq.gz | 3.8 GB | ||
| EGAF00004172652 | fastq.gz | 4.2 GB | ||
| EGAF00004172653 | fastq.gz | 3.3 GB | ||
| EGAF00004172654 | fastq.gz | 3.5 GB | ||
| EGAF00004172655 | fastq.gz | 3.1 GB | ||
| EGAF00004172656 | fastq.gz | 3.3 GB | ||
| EGAF00004172657 | fastq.gz | 1.6 GB | ||
| EGAF00004172658 | fastq.gz | 1.6 GB | ||
| EGAF00004172659 | fastq.gz | 5.6 GB | ||
| EGAF00004172660 | fastq.gz | 5.7 GB | ||
| EGAF00004172661 | fastq.gz | 3.4 GB | ||
| EGAF00004172662 | fastq.gz | 3.5 GB | ||
| EGAF00004172663 | fastq.gz | 2.3 GB | ||
| EGAF00004172664 | fastq.gz | 2.3 GB | ||
| EGAF00004172665 | fastq.gz | 3.1 GB | ||
| EGAF00004172666 | fastq.gz | 3.4 GB | ||
| EGAF00004172667 | fastq.gz | 3.0 GB | ||
| EGAF00004172668 | fastq.gz | 3.2 GB | ||
| EGAF00004172669 | fastq.gz | 4.9 GB | ||
| EGAF00004172670 | fastq.gz | 5.7 GB | ||
| EGAF00004172671 | fastq.gz | 3.4 GB | ||
| EGAF00004172672 | fastq.gz | 3.5 GB | ||
| EGAF00004172673 | fastq.gz | 4.5 GB | ||
| EGAF00004172674 | fastq.gz | 4.9 GB | ||
| EGAF00004172675 | fastq.gz | 2.9 GB | ||
| EGAF00004172676 | fastq.gz | 3.3 GB | ||
| EGAF00004172677 | fastq.gz | 3.2 GB | ||
| EGAF00004172678 | fastq.gz | 3.4 GB | ||
| EGAF00004172679 | fastq.gz | 5.1 GB | ||
| EGAF00004172680 | fastq.gz | 5.4 GB | ||
| EGAF00004172681 | fastq.gz | 3.6 GB | ||
| EGAF00004172682 | fastq.gz | 3.9 GB | ||
| EGAF00004172683 | fastq.gz | 3.3 GB | ||
| EGAF00004172684 | fastq.gz | 3.6 GB | ||
| EGAF00004172685 | fastq.gz | 3.9 GB | ||
| EGAF00004172686 | fastq.gz | 4.5 GB | ||
| EGAF00004172687 | fastq.gz | 3.1 GB | ||
| EGAF00004172688 | fastq.gz | 3.2 GB | ||
| EGAF00004172689 | fastq.gz | 3.5 GB | ||
| EGAF00004172690 | fastq.gz | 3.9 GB | ||
| EGAF00004172691 | fastq.gz | 3.1 GB | ||
| EGAF00004172692 | fastq.gz | 3.4 GB | ||
| EGAF00004172693 | fastq.gz | 2.9 GB | ||
| EGAF00004172694 | fastq.gz | 3.1 GB | ||
| EGAF00004172695 | fastq.gz | 2.9 GB | ||
| EGAF00004172696 | fastq.gz | 3.2 GB | ||
| EGAF00004172697 | fastq.gz | 3.2 GB | ||
| EGAF00004172698 | fastq.gz | 3.4 GB | ||
| EGAF00004172699 | fastq.gz | 2.5 GB | ||
| EGAF00004172700 | fastq.gz | 2.6 GB | ||
| EGAF00004172701 | fastq.gz | 3.6 GB | ||
| EGAF00004172702 | fastq.gz | 3.8 GB | ||
| EGAF00004172703 | fastq.gz | 2.8 GB | ||
| EGAF00004172704 | fastq.gz | 3.0 GB | ||
| EGAF00004172705 | fastq.gz | 2.8 GB | ||
| EGAF00004172706 | fastq.gz | 3.0 GB | ||
| EGAF00004172707 | fastq.gz | 3.3 GB | ||
| EGAF00004172708 | fastq.gz | 3.7 GB | ||
| EGAF00004172709 | fastq.gz | 3.3 GB | ||
| EGAF00004172710 | fastq.gz | 3.6 GB | ||
| EGAF00004172711 | fastq.gz | 2.9 GB | ||
| EGAF00004172712 | fastq.gz | 3.1 GB | ||
| EGAF00004172713 | fastq.gz | 2.9 GB | ||
| EGAF00004172714 | fastq.gz | 3.2 GB | ||
| EGAF00004172715 | fastq.gz | 3.8 GB | ||
| EGAF00004172716 | fastq.gz | 4.3 GB | ||
| EGAF00004172717 | fastq.gz | 3.6 GB | ||
| EGAF00004172718 | fastq.gz | 4.0 GB | ||
| EGAF00004172719 | fastq.gz | 2.1 GB | ||
| EGAF00004172720 | fastq.gz | 2.2 GB | ||
| EGAF00004172721 | fastq.gz | 1.8 GB | ||
| EGAF00004172722 | fastq.gz | 1.8 GB | ||
| 272 Files (926.2 GB) | ||||